Identification of the Micro‐Ribonucleic Acid Profiles of Plant‐Derived Extracellular Vesicles and their Potential Crosskingdom Regulation DOI Creative Commons
Fei Wang,

Junyao Deng,

Shushan Mo

et al.

Advanced NanoBiomed Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 30, 2025

Plant‐derived extracellular vesicles (pEVs) are nanosized that have comparable structure and properties to EVs derived from mammalian cells. Prior studies confirmed pEVs remarkable efficacy in the treatment of human diseases, such as cancer. As critical regulators gene expression, microRNAs (miRNAs) abundant pEVs. However, their potential functional roles regulatory mechanisms mediating crosskingdom regulation cells by remain undefined. In particular, similarities differences miRNA profiles various elusive. Herein, isolated grapefruit, ginger, lemon, grape, small RNA (sRNA) libraries constructed perform sRNA sequencing. Only 15 consistently expressed miRNAs identified these Furthermore, top 20 each pEV highly among total miRNAs, accounting for 79.93–87.12%. Through annotation analysis target genes, found be involved regulating progression cancer viral infection. Taken together, this study demonstrates contained play a role effects against genes highlights significant therapeutic applications diseases.

Language: Английский

Identification of the Micro‐Ribonucleic Acid Profiles of Plant‐Derived Extracellular Vesicles and their Potential Crosskingdom Regulation DOI Creative Commons
Fei Wang,

Junyao Deng,

Shushan Mo

et al.

Advanced NanoBiomed Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 30, 2025

Plant‐derived extracellular vesicles (pEVs) are nanosized that have comparable structure and properties to EVs derived from mammalian cells. Prior studies confirmed pEVs remarkable efficacy in the treatment of human diseases, such as cancer. As critical regulators gene expression, microRNAs (miRNAs) abundant pEVs. However, their potential functional roles regulatory mechanisms mediating crosskingdom regulation cells by remain undefined. In particular, similarities differences miRNA profiles various elusive. Herein, isolated grapefruit, ginger, lemon, grape, small RNA (sRNA) libraries constructed perform sRNA sequencing. Only 15 consistently expressed miRNAs identified these Furthermore, top 20 each pEV highly among total miRNAs, accounting for 79.93–87.12%. Through annotation analysis target genes, found be involved regulating progression cancer viral infection. Taken together, this study demonstrates contained play a role effects against genes highlights significant therapeutic applications diseases.

Language: Английский

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