Journal of Extracellular Biology, Journal Year: 2025, Volume and Issue: 4(5)
Published: May 1, 2025
ABSTRACT Extracellular vesicles (EVs) are small particles released by various cells, including cancer cells. They play a significant role in the development of different cancers, brain metastasis. These EVs transport biomolecular materials such as RNA, DNA, and proteins from tumour cells to other facilitating spread primary tumours tissue. interact with endothelial blood–brain barrier (BBB), compromising its integrity allowing metastatic pass through easily. Additionally, brain's microenvironment, creating conducive environment for incoming also influence immune system within this premetastatic environment, promoting growth This review paper focuses on research regarding metastasis, their impact disrupting BBB, preparing modulating system. Furthermore, discusses potential diagnostic prognostic biomarkers
Language: Английский