Functional materials, Journal Year: 2024, Volume and Issue: 31(4), P. 561 - 573
Published: Dec. 18, 2024
Some experiments with biological membranes have shown that a number of dopants can induce spontaneous lateral lipid separation into domains different physical properties even in monolipid membrane. Since most such are approved drug substances, one suppose this phenomenon is relevant to their therapeutic action. Such effect was observed for the bimodal adsorption. We assumed underlying mechanism dopant-induced domain formation preferential dopant binding ‘like surroundings′ rather than ‘unlike surroundings′. In present work, simulation method based on membrane has been developed. The sizes were calculated using simple procedure similar used percolation clusters. Using method, mean size largest grow by orders magnitude under moderate increase extent binding. This finding affirms as governing systems explored. Adsorption isotherms case sorption, albeit irrespective surrounding, analytically obtained. They coincide corresponding numerical results. be easily modified exploring any polymodal network connected sites, so it may see increased application future various physical, chemical, biological, biophysical and other systems.
Language: Английский