Impact of Immunosuppressants and Vaccination on COVID-19 Outcomes in Autoimmune Patients and Solid Organ Transplant Recipients: A Nationwide Propensity Score-Matched Study DOI Creative Commons
MinDong Sung, Young Sam Kim, Chang Jin Cho

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(10), P. 1190 - 1190

Published: Oct. 18, 2024

This study investigates the impact of varying degrees immunosuppression on clinical outcomes immunocompromised individuals, particularly those with autoimmune diseases or post-solid organ transplant statuses, in context COVID-19. By focusing these highly vulnerable populations, underscores significant health inequalities faced by patients, who experience disproportionately worse comparison to general population.

Language: Английский

Genotypic portrait of SARS-CoV-2 in Primorsky Krai during the COVID-19 pandemic DOI Creative Commons

Anna Y. Popova,

Shchelkanov MIu, Krylova Nv

et al.

Journal of microbiology epidemiology immunobiology, Journal Year: 2024, Volume and Issue: 101(1), P. 19 - 35

Published: March 9, 2024

Introduction. The COVID-19 pandemic, etiologically related to SARS-CoV-2, was the longest-lasting pandemic for an acute respiratory disease and had a significant impact on demography, economics politics globally. Experiences with this are sustainable development of human society. A detailed analysis these experiences in epidemic control should include details pathogen evolution down regional level. aim study establish regularities process connection change genetic variants territory Primorsky Krai. Materials methods. retrospective epidemiological incidence dynamics circulation SARS-CoV-2 during (11.03.2020–05.05.2023) Krai carried out. Data gathered from Department Rospotrebnadzor Krai, Centre Hygiene Epidemiology as well G.P. Somov Research Institute Microbiology Russian Federation Platform Aggregation Information Virus Genomes (VGARus). In particular, 1055 nucleotide sequences full-length genomes among which 553 were sequenced at included analysis. Results. When analyzing (2020–2023), 7 rises different clinical symptoms depending identified. At beginning throughout Russia, Wuhan-like predominant, though later, Delta Omicron majority. By end April — May 2023, proportion sub-variants (XBB.1.9.2 XBB.1.16) higher than average comparable that neighboring countries (Republic Korea Japan). Conclusion. Due ongoing possibility emergence new pathogens, peculiarities geographical location political economic importance it is necessary consistently improve capabilities operational molecular virological monitoring.

Language: Английский

Citations

4
The Humoral Immune Response Against COVID-19 Through Vaccination in Hemodialysis Patients DOI Creative Commons
Ji Young Park, Seong‐Ho Choi, Yong Kwan Lim

et al.

Vaccines, Journal Year: 2025, Volume and Issue: 13(2), P. 170 - 170

Published: Feb. 10, 2025

Background: This study investigated the humoral responses to SARS-CoV-2 in hemodialysis (HD) patients. The clearance of molecules blood during is influenced by factors such as filter pore size, flow rate, operating pressure, and treatment duration. Chronic kidney disease patients often show low antibody titers for pathogens like pneumococcus, influenza virus, hepatitis B virus. Methods: In this study, surrogate virus neutralization test (sVNT) wild type (WT) Omicron variants, well spike-specific IgG levels, were measured at two time points (May 2022 December 2023). Medical records questionnaires used gather participant information. Results: A total 26 HD enrolled, including 3 on immunosuppressive therapies. 8 had COVID-19 first sampling, 19 second. results showed that sVNT levels WT decreased over time, though positivity remained 100% both sampling periods. contrast, increased significantly, with rising from 46.2% 75.0% (p < 0.05). Spike-specific also increased, improving 96.2% 100%. Patients therapies significantly lower second period 0.05), no significant differences observed period. Conclusion: patients, particularly those therapies, reduced declining neutralizing time. meta-analysis seems necessary determine whether all dialysis need booster vaccinations, similar vaccine, highlighting targeted vaccination strategies.

Language: Английский

Citations

0
Dynamics of SARS-CoV-2 variants during the XBB wave in the Republic of Korea DOI Creative Commons
Jin Sun No,

Ji Yeong Noh,

Chae Young Lee

et al.

Virus Research, Journal Year: 2024, Volume and Issue: 350, P. 199471 - 199471

Published: Sept. 25, 2024

As COVID-19 has become endemic, SARS-CoV-2 variants are becoming increasingly diverse, underscoring the escalating importance of global genomic surveillance. This study analyzed 86,762 samples identified in Republic Korea from September 2022 to November 2023. The results revealed a consistent increase prevalence XBB following dominance BN.1, with various sub-lineages co-circulating Korea. overall nucleotide diversity (π) among genomes was 0.00155. Evolutionary analysis that average time interval between first detection and estimated date most recent common ancestor Korean 47 d, suggesting novel were efficiently surveillance system. mutation rate determined be range 5.6 × 10

Language: Английский

Citations

2
경북권 코로나바이러스감염증-19 변이 바이러스 감시 현황(2021–2023년) DOI Creative Commons

성희 오,

혜선 윤,

효진 김

et al.

Public Health Weekly Report, Journal Year: 2024, Volume and Issue: 17(15), P. 617 - 632

Published: Feb. 14, 2024

Citations

1
COVID-19 vaccine acceptance and 5C psychological antecedents amid the omicron surge in South Korea and China DOI
Minjung Lee, Chenyuan Qin, Yubin Lee

et al.

Vaccine, Journal Year: 2024, Volume and Issue: 43, P. 126515 - 126515

Published: Nov. 22, 2024

Language: Английский

Citations

1
Clinical performance of a rapid RT-PCR assay using STANDARD™ M10 SARS-CoV-2 between July 2022 and January 2023 in Korea DOI
Eunhee Han, Jinyeong Kim, Young Jin Kim

et al.

Diagnostic Microbiology and Infectious Disease, Journal Year: 2024, Volume and Issue: 110(4), P. 116523 - 116523

Published: Sept. 2, 2024

Language: Английский

Citations

0
Impact of Immunosuppressants and Vaccination on COVID-19 Outcomes in Autoimmune Patients and Solid Organ Transplant Recipients: A Nationwide Propensity Score-Matched Study DOI Creative Commons
MinDong Sung, Young Sam Kim, Chang Jin Cho

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(10), P. 1190 - 1190

Published: Oct. 18, 2024

This study investigates the impact of varying degrees immunosuppression on clinical outcomes immunocompromised individuals, particularly those with autoimmune diseases or post-solid organ transplant statuses, in context COVID-19. By focusing these highly vulnerable populations, underscores significant health inequalities faced by patients, who experience disproportionately worse comparison to general population.

Language: Английский

Citations

0