Virology, Journal Year: 2024, Volume and Issue: 603, P. 110353 - 110353
Published: Dec. 10, 2024
Language: Английский
Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)
Published: July 11, 2024
Abstract As one of the significant challenges to human health, cancer has long been a focal point in medical treatment. With ongoing advancements field medicine, numerous methodologies for therapy have emerged, among which oncolytic virus gained considerable attention. However, viruses still exhibit limitations. Combining them with various therapies can further enhance efficacy treatment, offering renewed hope patients. In recent research, scientists recognized promising prospect amalgamating diverse treatments, potentially surmounting restrictions singular approaches. The central concept this combined revolves around leveraging incite localized tumor inflammation, augmenting immune response immunotherapeutic efficacy. Through approach, patient's system better recognize and eliminate cells, simultaneously reducing evasion mechanisms against system. This review delves deeply into latest research progress concerning integration treatments its role types therapy. We aim analyze mechanisms, advantages, potential challenges, future directions combination By extensively exploring field, we instill fight cancer.
Language: Английский
Citations
11
Life Sciences, Journal Year: 2024, Volume and Issue: 356, P. 123018 - 123018
Published: Aug. 28, 2024
Language: Английский
Citations
5
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 1814 - 1814
Published: Feb. 20, 2025
Localization in the central nervous system, diffuse growth, presence of stem cells, and numerous resistance mechanisms, all make glioblastoma (GBM) an incurable tumor. The standard treatment GBM consisting surgery; radio- chemotherapy with temozolomide provides insufficient therapeutic benefit needs to be updated effective modern solutions. One most promising intensively explored approaches against is use nanotherapy. first, so far only, nanoparticle-based therapy approved for NanoThermTM. It based on iron oxide nanoparticles thermal ablation tumor a magnetic field. Numerous other types nanotherapies are being evaluated, including polymer lipid-based nanoformulations, nanodiscs, dendrimers, metallic, silica, or bioderived nanoparticles, among others. advantages these nanoscale drug carriers include improved penetration across blood-brain barrier, targeted delivery, biocompatibility, lower systemic toxicity, while major problems their implementation involve scaling up production high costs. Nevertheless, taking impressive benefits into consideration, it seems obvious that combined effort scientific world will need taken tackle challenges implement novel therapies clinics, giving hope battle can finally won.
Language: Английский
Citations
0
Biomedicines, Journal Year: 2024, Volume and Issue: 12(6), P. 1376 - 1376
Published: June 20, 2024
Glioblastoma multiforme (GBM) is one of the most aggressive forms brain tumor, characterized by a daunting prognosis with life expectancy hovering around 12–16 months. Despite century relentless research, only select few drugs have received approval for tumor treatment, largely due to formidable barrier posed blood–brain barrier. The current standard care involves multifaceted approach combining surgery, irradiation, and chemotherapy. However, recurrence often occurs within months despite these interventions. challenges drug delivery overcoming therapeutic resistance become focal points in treatment tumors are deemed essential recurrence. In recent years, promising wave advanced treatments has emerged, offering glimpse hope overcome limitations existing therapies. This review aims highlight cutting-edge technologies ongoing stages development, providing patients valuable insights guide their choices treatment.
Language: Английский
Citations
1
Computers in Biology and Medicine, Journal Year: 2024, Volume and Issue: 183, P. 109235 - 109235
Published: Oct. 5, 2024
Language: Английский
Citations
1
Frontiers in Life Sciences and Related Technologies, Journal Year: 2024, Volume and Issue: 5(2), P. 83 - 88
Published: Aug. 3, 2024
Doxycycline is a member of the tetracycline group and bacteriostatic antibiotic. Therefore, it stops/slows down reproduction spread pathogenic microorganisms gives immune system necessary time to destroy them. In this study, cytotoxic, anti-proliferative, apoptotic effects doxycycline on rat glioma cell line derived from Rattus norvegicus were observed. To show cytotoxicity doxycycline, MTT test was performed obtain IC50 value dosages treatment determined accordingly. With colony formation test, observed that reduced ability single cells. Similarly, wound healing also showed cells migrate. A dose-dependent decrease in number detected by DAPI staining after expression levels cancer related genes shown RT-qPCR method. conclusion, found have anti-proliferative cytotoxic line, more comprehensive studies are needed before can be used as complementary agent treatment.
Language: Английский
Citations
0
International Journal of Genomics, Journal Year: 2024, Volume and Issue: 2024(1)
Published: Jan. 1, 2024
This study investigates the prognostic significance of SH3 and multiple ankyrin repeat domains 2 (SHANK2) gene expression in glioma patients, using data from The Cancer Genome Atlas (TCGA), Genotype‐Tissue Expression (GTEx) project, Gene Omnibus (GEO). Through comprehensive analysis, we found a significant association between higher SHANK2 improved survival outcomes across various subtypes. To further validate clinical relevance SHANK2, conducted cellular experiments involving siRNA‐mediated knockdown U87 A172 cell lines. Quantitative real‐time PCR (qPCR) Western blot analyses confirmed successful subsequent MTT assays revealed that silencing significantly promoted proliferation. These findings underscore potential role as tumor suppressor glioma. also introduces multivariate model incorporating providing novel perspective on prognosis. While retrospective nature presents limitations, our results suggest could serve valuable biomarker for prognosis inform future therapeutic strategies.
Language: Английский
Citations
0
Virology, Journal Year: 2024, Volume and Issue: 603, P. 110353 - 110353
Published: Dec. 10, 2024
Language: Английский
Citations
0