Oncolytic Viruses in Ovarian Cancer: Where Do We Stand? A Narrative Review

Pathogens, Journal Year: 2025, Volume and Issue: 14(2), P. 140 - 140

Published: Feb. 3, 2025

Ovarian cancer (OC) remains the most lethal gynecologic malignancy with limited effective treatment options. Oncolytic viruses (OVs) have emerged as a promising therapeutic approach for treatment, capable of selectively infecting and lysing cells while stimulating anti-tumor immune responses. Preclinical studies demonstrated significant tumor regression prolonged survival in OC models using various OVs, such herpes simplex. Early-phase clinical trials shown favorable safety profile, though impact on patient has been modest. Current research focuses combining OVs other treatments like checkpoint inhibitors to enhance their efficacy. We provide comprehensive overview current understanding future directions utilizing management OC.

Language: Английский

Editorial: Viruses and Cancer

Virology, Journal Year: 2024, Volume and Issue: 603, P. 110353 - 110353

Published: Dec. 10, 2024

Language: Английский