Proteomic Analysis of 442 Clinical Plasma Samples From Individuals With Symptom Records Revealed Subtypes of Convalescent Patients Who Had COVID‐19

Journal of Medical Virology, Journal Year: 2025, Volume and Issue: 97(4)

Published: April 1, 2025

ABSTRACT After the coronavirus disease 2019 (COVID‐19) pandemic, postacute effects of severe acute respiratory syndrome 2 (SARS‐CoV‐2) infection have gradually attracted attention. To precisely evaluate health status convalescent patients with COVID‐19, we analyzed symptom and proteome data 442 plasma samples from healthy controls, hospitalized patients, 6 or 12 months after SARS‐CoV‐2 infection. Symptoms analysis revealed distinct relationships in patients. Results protein expression levels showed that C1QA, C1QB, C2, CFH, CFHR1, F10, which regulate complement system coagulation, remained highly expressed even at 12‐month follow‐up compared their individuals. By combining data, were categorized into three subtypes: S1 (metabolism‐healthy), S2 (COVID‐19 retention), S3 (long COVID). We speculated reporting hair loss could a better than those experiencing headaches dyspnea. Compared to other sleep disorders, appetite decrease, muscle weakness may need more attention because they classified subtype, had most COVID‐19. Subtyping COVID‐19 enable personalized treatments tailored individual needs. This study provides valuable proteomic datasets for further studies associated long COVID.

Language: Английский

Acute serum protein biomarker profile and prevalence of persistent (>6 months) neuropsychiatric symptoms in a cohort of SARS-CoV-2 PCR positive patients in Cape Town, South Africa.

Brain Behavior & Immunity - Health, Journal Year: 2025, Volume and Issue: unknown, P. 100990 - 100990

Published: April 1, 2025

Language: Английский