The HPV101 E7 protein shares host cellular targets and biological activities with high-risk HPV16 E7 DOI Creative Commons

Maya K. Gelbard,

Miranda Grace,

Annika von Schoeler-Ames

et al.

Tumour Virus Research, Journal Year: 2024, Volume and Issue: unknown, P. 200300 - 200300

Published: Dec. 1, 2024

Human papillomaviruses (HPVs) are a diverse family of viruses with over 450 members that have been identified and fully sequenced. They classified into five phylogenetic genera: alpha, beta, gamma, mu, nu. The high-risk alpha HPVs, such as HPV16, studied the most extensively due to their medical significance cancer-causing agents. However, while nearly 70% all HPVs gamma genus, they almost entirely unstudied. This is because considered medically irrelevant commensals them infect skin not known cause significant clinical lesions in immunocompetent individuals. Members 6 however, detected anogenital tract mucosa HPV101 has isolated from premalignant cervical lesion. Moreover, unique genome structure. lack E6 proteins but place E6, encode unique, tiny hydrophobic without any close viral or cellular homologs termed E10. Here we report E7 shares biochemical activities HPV16 E7, including ability target pRB PTPN tumor suppressor for degradation. study underscores importance further characterizing other unstudied HPV species.

Language: Английский

Post-Translational Modifications of Proteins Orchestrate All Hallmarks of Cancer DOI Creative Commons
Pathea Bruno,

Aneeta Arshad,

Maria-Raluca Gogu

et al.

Life, Journal Year: 2025, Volume and Issue: 15(1), P. 126 - 126

Published: Jan. 18, 2025

Post-translational modifications (PTMs) of proteins dynamically build the buffering and adapting interface between oncogenic mutations environmental stressors, on one hand, cancer cell structure, functioning, behavior. Aberrant PTMs can be considered as enabling characteristics long they orchestrate all malignant variability in proteome cells, cancer-associated tumor microenvironment (TME). On other enhance anticancer mechanisms tumoral ecosystem or sustain beneficial effects oncologic therapies through degradation inactivation carcinogenic or/and activation tumor-suppressor proteins. In this review, we summarized analyzed a wide spectrum involved regulatory that drive tumorigenesis, genetic instability, epigenetic reprogramming, events metastatic cascade, cytoskeleton extracellular matrix (ECM) remodeling, angiogenesis, immune response, tumor-associated microbiome, metabolism rewiring most important hallmarks cancer. All develop due to proteins, which modulate gene transcription, intracellular signaling, protein size, activity, stability localization, trafficking, secretion, half-life, protein–protein interactions (PPIs). associated with exploited better understand underlying molecular heterogeneous chameleonic disease, find new biomarkers progression prognosis, personalize oncotherapies, discover targets for drug development.

Language: Английский

Citations

2
Recent update on the Development of HPV16 inhibitors for Cervical Cancer DOI
Muhammad Shoaib, Amina Tariq, Yanchen Liu

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104703 - 104703

Published: March 1, 2025

Language: Английский

Citations

1
Targeting the interplay between human papillomavirus oncoproteins and hedgehog signaling: assessment of chemopreventive potential of carvacrol in cervical cancer DOI
Afza Ahmad, Rohit Kumar Tiwari, Irfan Ahmad Ansari

et al.

3 Biotech, Journal Year: 2025, Volume and Issue: 15(4)

Published: March 5, 2025

Language: Английский

Citations

0
Astragalin inhibits the proliferation of high-risk HPV-positive cervical epithelial cells and attenuates malignant cervical lesions DOI
Wei Zeng, Qiang Chen

Cytotechnology, Journal Year: 2025, Volume and Issue: 77(3)

Published: March 19, 2025

Language: Английский

Citations

0
The HPV101 E7 protein shares host cellular targets and biological activities with high-risk HPV16 E7 DOI Creative Commons

Maya K. Gelbard,

Miranda Grace,

Annika von Schoeler-Ames

et al.

Tumour Virus Research, Journal Year: 2024, Volume and Issue: unknown, P. 200300 - 200300

Published: Dec. 1, 2024

Human papillomaviruses (HPVs) are a diverse family of viruses with over 450 members that have been identified and fully sequenced. They classified into five phylogenetic genera: alpha, beta, gamma, mu, nu. The high-risk alpha HPVs, such as HPV16, studied the most extensively due to their medical significance cancer-causing agents. However, while nearly 70% all HPVs gamma genus, they almost entirely unstudied. This is because considered medically irrelevant commensals them infect skin not known cause significant clinical lesions in immunocompetent individuals. Members 6 however, detected anogenital tract mucosa HPV101 has isolated from premalignant cervical lesion. Moreover, unique genome structure. lack E6 proteins but place E6, encode unique, tiny hydrophobic without any close viral or cellular homologs termed E10. Here we report E7 shares biochemical activities HPV16 E7, including ability target pRB PTPN tumor suppressor for degradation. study underscores importance further characterizing other unstudied HPV species.

Language: Английский

Citations

0