Orthoflavivirus infection and the mTOR signaling pathway DOI Creative Commons
Yahui Zhang,

Jianbo Ba,

Jie Luan

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: April 9, 2025

Each year, mosquito-borne orthoflaviviruses, including Zika virus, dengue and the Japanese encephalitis threaten health of more than 400 million people worldwide. To date, knowledge about pathogenic mechanisms underlying orthoflavivirus infection interactions these viruses with host cells is limited. Mammalian target rapamycin (mTOR) pivotal for cell growth metabolism. The downstream targets mTOR regulate protein translation autophagy to affect replication, its upstream AKT performs similar functions. In this work, mechanism relationship between signaling pathway was reviewed from three perspectives: structure life cycle, pathway, regulation during infection.

Language: Английский

Orthoflavivirus infection and the mTOR signaling pathway DOI Creative Commons
Yahui Zhang,

Jianbo Ba,

Jie Luan

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: April 9, 2025

Each year, mosquito-borne orthoflaviviruses, including Zika virus, dengue and the Japanese encephalitis threaten health of more than 400 million people worldwide. To date, knowledge about pathogenic mechanisms underlying orthoflavivirus infection interactions these viruses with host cells is limited. Mammalian target rapamycin (mTOR) pivotal for cell growth metabolism. The downstream targets mTOR regulate protein translation autophagy to affect replication, its upstream AKT performs similar functions. In this work, mechanism relationship between signaling pathway was reviewed from three perspectives: structure life cycle, pathway, regulation during infection.

Language: Английский

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