Association between periodontitis and uric acid levels in blood and oral fluids: a systematic review and meta-analysis

BMC Oral Health, Journal Year: 2023, Volume and Issue: 23(1)

Published: March 27, 2023

Uric acid, a formerly-known antioxidant that has recently been linked to numerous inflammatory diseases as pro-inflammatory and -oxidative mediator in pathological conditions. It is imperative reassess the association between periodontitis uric acid locally systematically. The aim of this systematic review was systemically evaluate (UA) levels blood, saliva gingival crevicular fluid (GCF). Relevant clinical studies up January 28, 2023 were identified retrieved from electronic databases including PubMed, Scopus, EMBASE Web Science, with periodontitis, hyperuricemia gout keywords. weighted (WMD) or standardized mean difference (SMD) calculated using fixed- random-effect models. Methodological heterogeneity assessed. Sixteen eligible observational one RCT enrolled, which included 1354 patients 989 controls. Three sample types for UA detection involved, blood (n = 8), 9) GCF 1). Meta-analysis demonstrated an enhanced plasma concentration (WMD 1.00 mg/dL, 95% CI 0.63 1.37, P < 0.001) but decreased salivary level (SMD -0.95, -1.23 -0.68, versus control. Statistical among plasma- saliva-tested moderate (I2 58.3%, 0.066) low 33.8%, 0.196), respectively. Within limitations enrolled studies, it seems there increased UA. (Registration no. CRD42020172535 Prospero).

Language: Английский

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Superficial vein thrombosis: State of art. A review

Phlebology The Journal of Venous Disease, Journal Year: 2025, Volume and Issue: unknown

Published: May 3, 2025

Objectives Superficial venous thrombosis (SVT) is an acute affecting the superficial system, characterized by inflammation of wall. While much research has focused on deep vein (DVT), SVT historically been neglected due to its reputation as a benign and self-limiting condition. Methods A literature search was conducted using PubMed Google Scholar from January 2000 December 2023, focusing English-language publications including original articles, systematic reviews, randomized controlled trials. The following keywords were used in various combinations: “superficial thrombosis,” thrombophlebitis,” “phlebitis,” “thrombophlebitis.” review aimed analyze SVT, discuss key features, treatment approaches, prognosis. We identified 133 potentially relevant records, which 98 screened full text; 39 met our inclusion criteria (i.e., adult populations, clinical data incidence, risk factors, outcomes). PRISMA-style flowchart illustrates selection process reasons for exclusion (e.g., duplication, lack endpoints). Results common but often underestimated condition that can lead complications, pulmonary embolism. mainstay consists anticoagulant therapy, starting with low-dose unfractionated heparin or fondaparinux first-line drug, progressing oral anticoagulants at therapeutic doses more extensive cases. diagnosis primarily should be confirmed color Doppler ultrasound. Furthermore, may indicative serious underlying conditions. Conclusions considered benign, deceptive pathology. If not properly diagnosed treated, it progress DVT associated complications. Additionally, signal significant systemic conditions such malignancies, hereditary thrombophilia, cardiovascular diseases, warranting further investigation clinicians.

Language: Английский

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<p>Correlation Between Serum Uric Acid Level and Central Body Fat Distribution in Patients with Type 2 Diabetes</p>

Diabetes Metabolic Syndrome and Obesity, Journal Year: 2020, Volume and Issue: Volume 13, P. 2521 - 2531

Published: July 1, 2020

Background: The aim of this study was to investigate the correlation between serum uric acid level and central body fat distribution in patients with type 2 diabetes (T2DM). Methods: A total 867 T2DM were enrolled. Measurements obtained by dual energy X-ray absorptiometry. Patients stratified into three groups according their levels (SUA). Multiple linear regression analysis used determine association SUA distribution. Logistic estimate risk factors for hyperuricemia (HUA). Mediation applied assess overall, direct, indirect mediators levels. Results: showed that significantly positively correlated waist circumference (WC), mass index (BMI), visceral adipose tissue (VAT), subcutaneous (SAT), Android mass, Gynoid fasting c-peptide (F-CP), area under curve C-peptide (P < 0.05 all). VAT [odds ratio (OR), 2.367; 95% confidence interval (CI), 1.078– 5.197; P 0.001)], WC (OR, 1.041; CI, 1.011– 1.072; 0.001), high-density lipoprotein 0.274; 0.104– 0.727; estimated glomerular filtration rate 0.966; 0.959– 0.973; 0.001) found be independent HUA. After mediation analysis, BMI obesity have different partial effects on F-CP 0.001). Conclusion: In T2DM, HUA distribution, especially VAT. These results suggest may play a role positive insulin resistance (IR). Keywords: acid, obesity, diabetes,

Language: Английский

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Pro-Aging Effects of Xanthine Oxidoreductase Products

Antioxidants, Journal Year: 2020, Volume and Issue: 9(9), P. 839 - 839

Published: Sept. 8, 2020

The senescence process is the result of a series factors that start from genetic constitution interacting with epigenetic modifications induced by endogenous and environmental causes lead to progressive deterioration at cellular functional levels. One main aging oxidative stress deriving imbalance between production reactive oxygen (ROS) nitrogen (RNS) species their scavenging through antioxidants. Xanthine oxidoreductase (XOR) activities produce uric acid, as well species, which all may be relevant such equilibrium. This review analyzes XOR activity in vitro experiments, animal studies clinical reports, highlight pro-aging effects products. However, contributes regular level ROS RNS, appears essential for proper functioning many physiological pathways. discourages use therapies inhibitors, unless symptomatic hyperuricemia present.

Language: Английский

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Glucose, Fructose, and Urate Transporters in the Choroid Plexus Epithelium

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(19), P. 7230 - 7230

Published: Sept. 30, 2020

The choroid plexus plays a central role in the regulation of microenvironment nervous system by secreting majority cerebrospinal fluid and controlling its composition, despite that it only represents approximately 1% total brain weight. In addition to variety transporter channel proteins for solutes water, epithelial cells are equipped with glucose, fructose, urate transporters used as energy sources or antioxidative neuroprotective substrates. This review focuses on recent advances understanding SLC2A SLC5A families (GLUT1, SGLT2, GLUT5, GLUT8, GLUT9), well urate-transporting URAT1 BCRP/ABCG2, which expressed cells. repertoire epithelium share similar features renal proximal tubular epithelium, although some these exhibit inversely polarized submembrane localization. Since have high demands proper functioning, decline expression function can contribute process age-associated impairment pathophysiology neurodegenerative diseases.

Language: Английский

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Uric Acid in Metabolic and Cerebrovascular Disorders: A Review

Current Vascular Pharmacology, Journal Year: 2019, Volume and Issue: 18(6), P. 610 - 618

Published: Dec. 17, 2019

Several studies showed a close link between metabolic syndrome (MetS), type 2 diabetes (T2DM) and cerebrovascular diseases. There is considerable debate regarding the role of uric acid (UA) as risk factor in these conditions.The aim this narrative review to discuss links UA, MetS, T2DM disease.An extensive has been conducted based on scientific literature published English, indexed MEDLINE (through PubMed), EMBASE, Cochrane Library, Agency for Healthcare Research Quality, Google Scholar from January May 2019. Additional relevant after initial were also considered during period June 2019-October 2019, which, manuscript was written. The Mesh Terms were: acid, antioxidant, oxidant, syndrome, diabetes, diseases, stroke, haemorrhagic neurocognitive disorders, their combinations.The shows dose-dependent inflammatory action which occurs with serum concentrations >4 mg/dl (>0.24 mmol/l), representing one contributors chronic process that underlies diseases.UA, associated arterial hypertension cardiovascular represents indicators oxidative homeostasis. Increasing represent status active inflammation observed

Language: Английский

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Analyzing the Association between Hyperuricemia and Periodontitis: A Cross-Sectional Study Using KoGES HEXA Data

International Journal of Environmental Research and Public Health, Journal Year: 2020, Volume and Issue: 17(13), P. 4777 - 4777

Published: July 2, 2020

Hyperuricemia arises from the buildup of excessive uric acid in blood, and it is implicated development periodontitis. The objective this study was to investigate association between hyperuricemia periodontitis using a cross-sectional design Korean Genome Epidemiology Study Health Examinee (KoGES HEXA) data. This prospective cohort used epidemiological data KoGES 2004 2016. Among 173,209 participants, 8809 with 126,465 controls (non-hyperuricemia) were selected. defined as >7.0 mg/dL men >6.0 women. analyzed history among control participants. Participants' age, gender, income, obesity, smoking, alcohol consumption, nutritional intake all examined. Chi-square tests, independent t-tests, two-tailed analyses for statistical analysis. adjusted OR (aOR) 0.89 (95% confidence interval (CI) = 0.81-0.96, p 0.005). demonstrated that associated finding meant elevated levels could have positive effect on However, further studies should be performed determine range beneficial periodontal health.

Language: Английский

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Hyperuricemia as a potential plausible risk factor for periodontitis

Medical Hypotheses, Journal Year: 2020, Volume and Issue: 137, P. 109591 - 109591

Published: Jan. 23, 2020

Language: Английский

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Uric acid and uric acid to creatinine ratio in the assessment of chronic obstructive pulmonary disease: Potential biomarkers in multicomponent models comprising IL-1beta

PLoS ONE, Journal Year: 2020, Volume and Issue: 15(6), P. e0234363 - e0234363

Published: June 5, 2020

Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous disease, with oxidative stress inflammation implicated in its development. Uric acid (UA) could exert anti-oxidative, pro-oxidative or pro-inflammatory effects, depending on the specific context. It was recently shown that soluble UA, not just crystals, activate nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, leading to interleukin (IL)-1β secretion. We aimed assess differences blood levels of UA ratio creatinine (UCR) between COPD patients healthy subjects, as well their association severity, smoking status, common comorbidities therapy regimes. The diagnostic characteristics UCR were also explored. This study included 109 stable 95 controls measured white cells (WBC), C-reactive protein (CRP), fibrinogen (Fbg), IL-1β, (CREAT) UA. All parameters increased patients, except for CREAT. positively associated WBC, CRP IL-1β. smokers had lower values. Common did affect UCR, while cardiovascular diseases (CVD) higher but levels. Patients values showed worse disease-related outcomes (lung function, symptoms, quality life, history exacerbations, BODCAT BODEx). Also, differentiated different severity airflow limitation symptoms exacerbations. great individual predictive potential IL-1β observed odds ratios (OR) being 2.09 5.53, respectively. Multiparameter models able correctly classify 86% 90% cases, suggest might be useful biomarker when combined even more informative overall assessments.

Language: Английский

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The Cardiovascular Disease (CVD) Risk Continuum from Prenatal Life to Adulthood: A Literature Review

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(14), P. 8282 - 8282

Published: July 7, 2022

The risk of developing cardiovascular diseases (CVDs) arises from the interaction prenatal factors; epigenetic regulation; neonatal and factors that affect childhood adolescence, such as early adiposity rebound (AR) social environmental influences. Thus, CVD varies between group low-risk metabolically healthy normal-weight subjects (MHNW); intermediate-risk group, which includes obese (MHO) unhealthy (MUHNW); high-risk (MUHO) subjects. In this continuum, several come into play contribute to endothelial damage, vascular myocardial remodeling, atherosclerotic processes. These pathologies can occur both in life significantly increasing young adults over time. Early intervention pediatric MUHO population reduce during adulthood remains a challenge. review, we focus on arising at different stages by performing search recent literature. It is urgent preventive or therapeutic strategies stop disturbing negative metabolic trend, manifests continuum adulthood.

Language: Английский

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