BMC Oral Health,
Journal Year:
2023,
Volume and Issue:
23(1)
Published: March 27, 2023
Uric
acid,
a
formerly-known
antioxidant
that
has
recently
been
linked
to
numerous
inflammatory
diseases
as
pro-inflammatory
and
-oxidative
mediator
in
pathological
conditions.
It
is
imperative
reassess
the
association
between
periodontitis
uric
acid
locally
systematically.
The
aim
of
this
systematic
review
was
systemically
evaluate
(UA)
levels
blood,
saliva
gingival
crevicular
fluid
(GCF).
Relevant
clinical
studies
up
January
28,
2023
were
identified
retrieved
from
electronic
databases
including
PubMed,
Scopus,
EMBASE
Web
Science,
with
periodontitis,
hyperuricemia
gout
keywords.
weighted
(WMD)
or
standardized
mean
difference
(SMD)
calculated
using
fixed-
random-effect
models.
Methodological
heterogeneity
assessed.
Sixteen
eligible
observational
one
RCT
enrolled,
which
included
1354
patients
989
controls.
Three
sample
types
for
UA
detection
involved,
blood
(n
=
8),
9)
GCF
1).
Meta-analysis
demonstrated
an
enhanced
plasma
concentration
(WMD
1.00
mg/dL,
95%
CI
0.63
1.37,
P
<
0.001)
but
decreased
salivary
level
(SMD
-0.95,
-1.23
-0.68,
versus
control.
Statistical
among
plasma-
saliva-tested
moderate
(I2
58.3%,
0.066)
low
33.8%,
0.196),
respectively.
Within
limitations
enrolled
studies,
it
seems
there
increased
UA.
(Registration
no.
CRD42020172535
Prospero).
Phlebology The Journal of Venous Disease,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 3, 2025
Objectives
Superficial
venous
thrombosis
(SVT)
is
an
acute
affecting
the
superficial
system,
characterized
by
inflammation
of
wall.
While
much
research
has
focused
on
deep
vein
(DVT),
SVT
historically
been
neglected
due
to
its
reputation
as
a
benign
and
self-limiting
condition.
Methods
A
literature
search
was
conducted
using
PubMed
Google
Scholar
from
January
2000
December
2023,
focusing
English-language
publications
including
original
articles,
systematic
reviews,
randomized
controlled
trials.
The
following
keywords
were
used
in
various
combinations:
“superficial
thrombosis,”
thrombophlebitis,”
“phlebitis,”
“thrombophlebitis.”
review
aimed
analyze
SVT,
discuss
key
features,
treatment
approaches,
prognosis.
We
identified
133
potentially
relevant
records,
which
98
screened
full
text;
39
met
our
inclusion
criteria
(i.e.,
adult
populations,
clinical
data
incidence,
risk
factors,
outcomes).
PRISMA-style
flowchart
illustrates
selection
process
reasons
for
exclusion
(e.g.,
duplication,
lack
endpoints).
Results
common
but
often
underestimated
condition
that
can
lead
complications,
pulmonary
embolism.
mainstay
consists
anticoagulant
therapy,
starting
with
low-dose
unfractionated
heparin
or
fondaparinux
first-line
drug,
progressing
oral
anticoagulants
at
therapeutic
doses
more
extensive
cases.
diagnosis
primarily
should
be
confirmed
color
Doppler
ultrasound.
Furthermore,
may
indicative
serious
underlying
conditions.
Conclusions
considered
benign,
deceptive
pathology.
If
not
properly
diagnosed
treated,
it
progress
DVT
associated
complications.
Additionally,
signal
significant
systemic
conditions
such
malignancies,
hereditary
thrombophilia,
cardiovascular
diseases,
warranting
further
investigation
clinicians.
Current Vascular Pharmacology,
Journal Year:
2019,
Volume and Issue:
18(6), P. 610 - 618
Published: Dec. 17, 2019
Several
studies
showed
a
close
link
between
metabolic
syndrome
(MetS),
type
2
diabetes
(T2DM)
and
cerebrovascular
diseases.
There
is
considerable
debate
regarding
the
role
of
uric
acid
(UA)
as
risk
factor
in
these
conditions.The
aim
this
narrative
review
to
discuss
links
UA,
MetS,
T2DM
disease.An
extensive
has
been
conducted
based
on
scientific
literature
published
English,
indexed
MEDLINE
(through
PubMed),
EMBASE,
Cochrane
Library,
Agency
for
Healthcare
Research
Quality,
Google
Scholar
from
January
May
2019.
Additional
relevant
after
initial
were
also
considered
during
period
June
2019-October
2019,
which,
manuscript
was
written.
The
Mesh
Terms
were:
acid,
antioxidant,
oxidant,
syndrome,
diabetes,
diseases,
stroke,
haemorrhagic
neurocognitive
disorders,
their
combinations.The
shows
dose-dependent
inflammatory
action
which
occurs
with
serum
concentrations
>4
mg/dl
(>0.24
mmol/l),
representing
one
contributors
chronic
process
that
underlies
diseases.UA,
associated
arterial
hypertension
cardiovascular
represents
indicators
oxidative
homeostasis.
Increasing
represent
status
active
inflammation
observed
Diabetes Metabolic Syndrome and Obesity,
Journal Year:
2020,
Volume and Issue:
Volume 13, P. 2521 - 2531
Published: July 1, 2020
Background:
The
aim
of
this
study
was
to
investigate
the
correlation
between
serum
uric
acid
level
and
central
body
fat
distribution
in
patients
with
type
2
diabetes
(T2DM).
Methods:
A
total
867
T2DM
were
enrolled.
Measurements
obtained
by
dual
energy
X-ray
absorptiometry.
Patients
stratified
into
three
groups
according
their
levels
(SUA).
Multiple
linear
regression
analysis
used
determine
association
SUA
distribution.
Logistic
estimate
risk
factors
for
hyperuricemia
(HUA).
Mediation
applied
assess
overall,
direct,
indirect
mediators
levels.
Results:
showed
that
significantly
positively
correlated
waist
circumference
(WC),
mass
index
(BMI),
visceral
adipose
tissue
(VAT),
subcutaneous
(SAT),
Android
mass,
Gynoid
fasting
c-peptide
(F-CP),
area
under
curve
C-peptide
(P
<
0.05
all).
VAT
[odds
ratio
(OR),
2.367;
95%
confidence
interval
(CI),
1.078–
5.197;
P
0.001)],
WC
(OR,
1.041;
CI,
1.011–
1.072;
0.001),
high-density
lipoprotein
0.274;
0.104–
0.727;
estimated
glomerular
filtration
rate
0.966;
0.959–
0.973;
0.001)
found
be
independent
HUA.
After
mediation
analysis,
BMI
obesity
have
different
partial
effects
on
F-CP
0.001).
Conclusion:
In
T2DM,
HUA
distribution,
especially
VAT.
These
results
suggest
may
play
a
role
positive
insulin
resistance
(IR).
Keywords:
acid,
obesity,
diabetes,
Antioxidants,
Journal Year:
2020,
Volume and Issue:
9(9), P. 839 - 839
Published: Sept. 8, 2020
The
senescence
process
is
the
result
of
a
series
factors
that
start
from
genetic
constitution
interacting
with
epigenetic
modifications
induced
by
endogenous
and
environmental
causes
lead
to
progressive
deterioration
at
cellular
functional
levels.
One
main
aging
oxidative
stress
deriving
imbalance
between
production
reactive
oxygen
(ROS)
nitrogen
(RNS)
species
their
scavenging
through
antioxidants.
Xanthine
oxidoreductase
(XOR)
activities
produce
uric
acid,
as
well
species,
which
all
may
be
relevant
such
equilibrium.
This
review
analyzes
XOR
activity
in
vitro
experiments,
animal
studies
clinical
reports,
highlight
pro-aging
effects
products.
However,
contributes
regular
level
ROS
RNS,
appears
essential
for
proper
functioning
many
physiological
pathways.
discourages
use
therapies
inhibitors,
unless
symptomatic
hyperuricemia
present.
International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(19), P. 7230 - 7230
Published: Sept. 30, 2020
The
choroid
plexus
plays
a
central
role
in
the
regulation
of
microenvironment
nervous
system
by
secreting
majority
cerebrospinal
fluid
and
controlling
its
composition,
despite
that
it
only
represents
approximately
1%
total
brain
weight.
In
addition
to
variety
transporter
channel
proteins
for
solutes
water,
epithelial
cells
are
equipped
with
glucose,
fructose,
urate
transporters
used
as
energy
sources
or
antioxidative
neuroprotective
substrates.
This
review
focuses
on
recent
advances
understanding
SLC2A
SLC5A
families
(GLUT1,
SGLT2,
GLUT5,
GLUT8,
GLUT9),
well
urate-transporting
URAT1
BCRP/ABCG2,
which
expressed
cells.
repertoire
epithelium
share
similar
features
renal
proximal
tubular
epithelium,
although
some
these
exhibit
inversely
polarized
submembrane
localization.
Since
have
high
demands
proper
functioning,
decline
expression
function
can
contribute
process
age-associated
impairment
pathophysiology
neurodegenerative
diseases.
International Journal of Environmental Research and Public Health,
Journal Year:
2020,
Volume and Issue:
17(13), P. 4777 - 4777
Published: July 2, 2020
Hyperuricemia
arises
from
the
buildup
of
excessive
uric
acid
in
blood,
and
it
is
implicated
development
periodontitis.
The
objective
this
study
was
to
investigate
association
between
hyperuricemia
periodontitis
using
a
cross-sectional
design
Korean
Genome
Epidemiology
Study
Health
Examinee
(KoGES
HEXA)
data.
This
prospective
cohort
used
epidemiological
data
KoGES
2004
2016.
Among
173,209
participants,
8809
with
126,465
controls
(non-hyperuricemia)
were
selected.
defined
as
>7.0
mg/dL
men
>6.0
women.
analyzed
history
among
control
participants.
Participants'
age,
gender,
income,
obesity,
smoking,
alcohol
consumption,
nutritional
intake
all
examined.
Chi-square
tests,
independent
t-tests,
two-tailed
analyses
for
statistical
analysis.
adjusted
OR
(aOR)
0.89
(95%
confidence
interval
(CI)
=
0.81-0.96,
p
0.005).
demonstrated
that
associated
finding
meant
elevated
levels
could
have
positive
effect
on
However,
further
studies
should
be
performed
determine
range
beneficial
periodontal
health.
PLoS ONE,
Journal Year:
2020,
Volume and Issue:
15(6), P. e0234363 - e0234363
Published: June 5, 2020
Chronic
obstructive
pulmonary
disease
(COPD)
is
a
complex
and
heterogeneous
disease,
with
oxidative
stress
inflammation
implicated
in
its
development.
Uric
acid
(UA)
could
exert
anti-oxidative,
pro-oxidative
or
pro-inflammatory
effects,
depending
on
the
specific
context.
It
was
recently
shown
that
soluble
UA,
not
just
crystals,
activate
nucleotide-binding
oligomerization
domain-like
receptor
family
pyrin
domain-containing
3
(NLRP3)
inflammasome,
leading
to
interleukin
(IL)-1β
secretion.
We
aimed
assess
differences
blood
levels
of
UA
ratio
creatinine
(UCR)
between
COPD
patients
healthy
subjects,
as
well
their
association
severity,
smoking
status,
common
comorbidities
therapy
regimes.
The
diagnostic
characteristics
UCR
were
also
explored.
This
study
included
109
stable
95
controls
measured
white
cells
(WBC),
C-reactive
protein
(CRP),
fibrinogen
(Fbg),
IL-1β,
(CREAT)
UA.
All
parameters
increased
patients,
except
for
CREAT.
positively
associated
WBC,
CRP
IL-1β.
smokers
had
lower
values.
Common
did
affect
UCR,
while
cardiovascular
diseases
(CVD)
higher
but
levels.
Patients
values
showed
worse
disease-related
outcomes
(lung
function,
symptoms,
quality
life,
history
exacerbations,
BODCAT
BODEx).
Also,
differentiated
different
severity
airflow
limitation
symptoms
exacerbations.
great
individual
predictive
potential
IL-1β
observed
odds
ratios
(OR)
being
2.09
5.53,
respectively.
Multiparameter
models
able
correctly
classify
86%
90%
cases,
suggest
might
be
useful
biomarker
when
combined
even
more
informative
overall
assessments.
International Journal of Environmental Research and Public Health,
Journal Year:
2022,
Volume and Issue:
19(14), P. 8282 - 8282
Published: July 7, 2022
The
risk
of
developing
cardiovascular
diseases
(CVDs)
arises
from
the
interaction
prenatal
factors;
epigenetic
regulation;
neonatal
and
factors
that
affect
childhood
adolescence,
such
as
early
adiposity
rebound
(AR)
social
environmental
influences.
Thus,
CVD
varies
between
group
low-risk
metabolically
healthy
normal-weight
subjects
(MHNW);
intermediate-risk
group,
which
includes
obese
(MHO)
unhealthy
(MUHNW);
high-risk
(MUHO)
subjects.
In
this
continuum,
several
come
into
play
contribute
to
endothelial
damage,
vascular
myocardial
remodeling,
atherosclerotic
processes.
These
pathologies
can
occur
both
in
life
significantly
increasing
young
adults
over
time.
Early
intervention
pediatric
MUHO
population
reduce
during
adulthood
remains
a
challenge.
review,
we
focus
on
arising
at
different
stages
by
performing
search
recent
literature.
It
is
urgent
preventive
or
therapeutic
strategies
stop
disturbing
negative
metabolic
trend,
manifests
continuum
adulthood.