Associations of dietary inflammation index and composite dietary antioxidant index with preserved ratio impaired spirometry in US adults and the mediating roles of triglyceride-glucose index: NHANES 2007–2012

Redox Biology, Journal Year: 2024, Volume and Issue: 76, P. 103334 - 103334

Published: Aug. 30, 2024

Previous studies have shown that inflammatory and antioxidant dietary patterns can modify the risk of COPD, yet few examined association these diets with its early signs (PRISm), potential role metabolic disorders remains to be elucidated.

Language: Английский

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Exploring the application of dietary antioxidant index for disease risk assessment: a comprehensive review

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 16, 2025

Oxidative stress contributes to the development of cardiometabolic diseases and cancers. Numerous studies have highlighted adverse effects high reactive oxygen species (ROS) levels in progression chronic noncommunicable also during infections. On other hand, antioxidants play a crucial role preventing oxidative or postponing cell damage via direct scavenging free radicals indirectly Keap1/Nrf2/ARE pathway, among others. Dietary can be obtained from various sources, mainly through plant-based diet, including fruits vegetables. The dietary antioxidant index (DAI) has been developed assess total intake diet. This review delineated performance DAI risk assessment different diseases. It is suggested that score prevents obesity-related diseases, diabetes mellitus, hyperuricemia, dyslipidemia, metabolic (dysfunction)-associated steatotic liver disease (MASLD). Additionally, negatively associated with Helicobacter pylori Human papillomavirus infection, thus reducing gastric cervical cancer. Also, osteoporosis, miscarriage, infertility, mental illnesses. However, further prospective observations clinical trials are warranted confirm application studied.

Language: Английский

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The Composite Dietary Antioxidant Index is Associated With Common Non-communicable Diseases: The Mediation and Joint Effects of Inflammatory Indices

Biological Research For Nursing, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Purpose: To evaluate the associations between composite dietary antioxidant index (CDAI) and common non-communicable diseases (NCDs) explore potential effects of inflammatory indices in these associations. Methods: We included 20,097 adults from National Health Nutrition Examination Survey 2003-2018. Multivariable logistic regressions were applied to CDAI NCDs. Mediation analysis was used role Results: Higher associated with a downward trend incidence obesity, cardiovascular disease (CVD), chronic respiratory diseases, kidney (CKD) (p for < 0.05). The association CVD influenced by C-reactive protein (CRP), red blood cell width (RDW), neutrophil lymphocyte ratio (NLR), mediated proportions 3.490%, 5.173%, 2.351%, respectively. NLR partially contributed link CKD, mediating 2.746%. Additionally, we observed additive interactions CRP (RERI (95% CI): 0.282 (0.070, 0.494), AP 0.539 (0.088, 0.991), as well RDW on 0.318 (0.124, 0.511), 0.717 (0.217, 1.218)). There also appeared be weak multiplicative interaction (p-int = 0.049). Conclusion: Our investigation ascertained that related Moreover, played an important

Language: Английский

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Unhealthy Food Consumption Is Associated with Post-Acute Sequelae of COVID-19 in Brazilian Elderly People

Infectious Disease Reports, Journal Year: 2025, Volume and Issue: 17(2), P. 25 - 25

Published: March 13, 2025

Background/Objectives: The factors associated with post-acute sequelae of COVID-19 (PASC) are not yet fully understood in developing countries. Our objective was to investigate the relationship between food consumption and occurrence PASC Brazilian elderly people. Methods: This cross-sectional study included 1322 people aged 60 or over, infected SARS-CoV-2 2020, living state Roraima Brazil. Using National Food Nutrition Surveillance System (SISVAN, Portuguese) tool, markers were evaluated. persistence assessed three months after infection. Poisson regression robust variance performed estimate prevalence ratio (PR) a 95% confidence interval (95% CI). Results: Fruit [PR 0.92; CI: 0.85–0.99] lower PASC, significant interaction individuals 69 years old, hospitalized, those without chronic kidney disease. In addition, sugar-sweetened beverages 1.23; 1.12–1.35], sandwich cookies, sweets, treats 1.12; CI 1.03–1.22] positively people, capital hypercholesterolemia. Conclusions: Unhealthy An improvement diet quality is necessary minimize health complications PASC.

Language: Английский

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Nutritional Support of Chronic Obstructive Pulmonary Disease

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1149 - 1149

Published: March 26, 2025

Background: COPD is a heterogenous disease of the respiratory tract caused by diverse genetic factors along with environmental and lifestyle-related effects such as industrial dust inhalation and, most frequently, cigarette smoking. These lead to airflow obstruction chronic symptoms. Additionally, increased risk infections exacerbates airway inflammation in patients. As consequence complex pathomechanisms difficulty treatment, among leading causes mortality both western countries developing world. Results: The management still challenge for clinicians; however, alternative interventions smoking cessation lifestyle changes from sedentary life moderate physical activity special attention diet may ameliorate patients' health. Here, we reviewed different dietary components supplements on conditions COPD. Conclusions: patients are continuously exposed heavy metals, which commonly present smoke polluted air. Meanwhile, they often experience significant nutrient deficiencies, affect detoxification these toxic metals. This turn can further disrupt nutritional balance interfering absorption, metabolism, utilization essential micronutrients. Therefore, awareness deliberate efforts should be made check levels micronutrients, ensuring adequate antioxidants, vitamin D, K2, magnesium, iron, particularly important reducing development limiting severity.

Language: Английский

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Association between the composite dietary antioxidant index and non-alcoholic fatty liver disease: evidence from National Health and Nutrition Examination Survey 2005–2016

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 23, 2025

Importance Oxidative stress contributes to the progression of non-alcoholic fatty liver disease (NAFLD). Antioxidants from food can reduce NAFLD incidence, and Composite Dietary Antioxidant Index (CDAI) measures total antioxidant capacity (TAC). However, relationship between CDAI in US adult population remains unclear. Objective To assess whether is associated with adults. Design, setting, participants This population-based cross-sectional study used data on adults National Health Nutrition Examination Survey (NHANES) 2005–2016 cycles. Data were analyzed January February 2024. Exposures obtained dietary intake questionnaire. Main outcomes The main outcome was which defined by score (USFLI) ≥30. Sampling weights calculated according NHANES guidelines. Results Among 9,746 included this [mean age, 48.3 years; 4,662 (47.6%) males], 3,324 (33.0%) classified as having using USFLI. In fully adjusted multivariable logistic regression, negatively (odds ratio [OR], 0.95; 95% CI, 0.93–0.98). Furthermore, individuals highest quartile 34% less likely have compared those lowest (OR, 0.66; 0.52–0.85). subgroup analyses, inversely among a BMI &lt;25 0.89; 0.83–0.95) without metabolic syndrome 0.93; 0.91–0.96). interaction tests revealed significant differences these subgroups ( P for = 0.04 0.003 syndrome). Sensitivity analyses confirmed association hepatic steatosis index (HSI) define NAFLD, applying unweighted adjusting physical activity or after excluding non-Hispanic Black participants, medications known their potential hepatotoxic effects. Conclusions relevance based six cycles (2005–2016) NHANES, population. highlights interventions incidence underscores need future research, including clinical trials mechanistic studies, further explore role antioxidants prevention management.

Language: Английский

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Antioxidant and Inflammatory Potential of Diet is Associated with Risk of Asthma-Chronic Obstructive Pulmonary Disease Overlap: Findings from NHANES (2003-2018)

Nutrition Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Role of Serum and Dietary Vitamins A and E in Pulmonary Function and Chronic Obstructive Pulmonary Disease: A Systematic Review

Pakistan Journal of Health Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Chronic Obstructive Pulmonary Disease (COPD) is a major global health concern, significantly affecting quality of life and healthcare systems. Oxidative stress plays critical role in COPD pathogenesis. Vitamins A E, as fat-soluble antioxidants, are believed to support pulmonary health, but studies report conflicting findings. Objectives: To evaluate associations between serum dietary concentrations vitamins E with function parameters risk or severity, this systematic review was conducted. Methods: search conducted PubMed, EMBASE, Scopus, the Cochrane Library. Of 150 screened studies, 22 met inclusion criteria, comprising cross-sectional, cohort, case-control, interventional designs. Studies assessing levels their relationships (FEV₁, FVC, FEV₁/FVC) were included. Results: Higher vitamin linked improved FEV₁ FVC reduced prevalence. Vitamin intake associated lower COPD, though its effects on lung varied. Supplementation showed mixed results, benefits observed mainly when combined other antioxidants. Effects more pronounced smokers individuals systemic inflammation. Conclusions: particularly A, may slow progression. However, inconsistencies highlighted need for well-designed trials confirm management.

Language: Английский

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Associations of composite dietary antioxidant index with suicidal ideation incidence and mortality among the U.S. population

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Oct. 7, 2024

Background The relationship between CDAI and suicidal ideation is unclear. This study investigates the examines association all-cause mortality (ACM) or cardiovascular disease (CVM) among participants with without ideation. Methods Data from seven NHANES cycles (2005–2018) were analyzed using cross-sectional prospective cohort studies. Weighted multivariable logistic regression models, restricted cubic spline (RCS) plots, subgroup analyses explored Kaplan–Meier (KM) curves, weighted Cox proportional hazards RCS assessed CVM ACM. Results Among 30,976 aged over 20, 1,154 (3.72%) had Higher levels (Quartile 4) associated a 28% reduction in compared to lower 1). Over an average follow-up of 89 months, 3,267 (7.6%) died, including 808 (1.8%) causes. linked 30, 68, ACM total population, those ideation, without, respectively. was reduced by 40% population 41% Conclusion negatively correlated

Language: Английский

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Therapeutic effect of targeted antioxidant natural products

Discover Nano, Journal Year: 2024, Volume and Issue: 19(1)

Published: Sept. 10, 2024

The exploration of targeted therapy has proven to be a highly promising avenue in the realm drug development research. human body generates substantial amount free radicals during metabolic processes, and if not promptly eliminated, these can lead oxidative stress, disrupting homeostasis potentially contributing chronic diseases cancers. Before contemporary medicine with synthetic pharmaceuticals antioxidants, there was long-standing practice employing raw, natural ingredients cure variety illnesses. This persisted even after active antioxidant molecules were known. ability antioxidants neutralise excess so prevent wide range term "natural antioxidant" refers compounds derived from plants or other living organisms that have control production radicals, scavenge them, stop radical-mediated chain reactions, lipid peroxidation. These strong potential inhibit stress. Phytochemicals (antioxidants) plants, such as polyphenols, carotenoids, vitamins, others, are central discussion antioxidants. Not only may chemicals increase endogenous defenses, affect communication cascades, gene expression, but they also shown radical scavenging properties. study comprehensively summarizes primary classes found different plant animal source contribute prevention treatment diseases. Additionally, it outlines research progress future prospects. discoveries establish theoretical groundwork for pharmacological present inventive ideas addressing challenges medical treatment.

Language: Английский

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