Lifestyle Factors and Associations with Individual and Comorbid Cardiometabolic and Pulmonary Disease Among U.S. Adults DOI Open Access
Osayande Agbonlahor, Delvon T. Mattingly,

Maggie K. Richardson

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2024, Volume and Issue: 21(12), P. 1674 - 1674

Published: Dec. 16, 2024

Background: Although lifestyle factors have been linked to chronic diseases among adults, their association with diagnosed individual and comorbid cardiometabolic (CMD) pulmonary disease (PD) is not fully known. This study aimed examine the associations between CMD PD U.S. adults. Methods: We used cross-sectional data from 2017–2020 National Health Nutrition Examination Survey (n = 7394). care provider’s diagnosis of (i.e., past 5-day tobacco use, 12-month alcohol diet, sleep troubles, physical activity) were assessed. Adjusted odds ratios estimated using logistic multinomial regression. Results: Trouble sleeping was associated increased (OR: 2.47) 2.29) individually, while activity lower 0.75, OR: 0.77). Past 2.36) year 1.61) use odds. Lifestyle PD. Conclusions: prevention should involve promoting modification implementation policies that eliminate structural barriers healthy adoption.

Language: Английский

Associations of serum Cu, Zn, and Se with Chronic Respiratory Diseases in the American adults: Data from NHANES 2013–2016 and a bidirectional Mendelian randomization analysis DOI Creative Commons

Hanming Yu,

Taihong Lv,

Zishuo Ji

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: March 28, 2024

Abstract Background Despite studies on trace metals and Chronic Respiratory Diseases (CRDs), their causal relationship in American adults is uncertain. Our research applied observational bidirectional Mendelian randomization (MR) methods to ascertain this association. Objective The aim of study was evaluate the potential linkages between serum levels copper (Cu), zinc (Zn), selenium (Se) incidence chronic respiratory diseases within adult demographic United States. Methods Drawing National Health Nutrition Examination Survey (NHANES) 2013–2016 data, our incorporated 2807 examine Cu, Zn, Se impacts CRDs risks using logistic regression cubic spline analysis. Subsequently, MR assessments were conducted causative pertaining these associations. Results Employing adjusted-weighted models, high Cu significantly escalated for emphysema (OR: 3.83) obstructive pulmonary disease (COPD) 2.14–3.33), while elevated Zn corresponded respective OR 1.82 1.91 tracheitis COPD. Conversely, moderate reduced risk 0.64). indicated no genetic causation ( p > 0.05), yet exposure causally linked COPD = 0.003), as 0.014). selenium’s protective association with confirmed 0.010). Conclusion High links increased emphysema, tracheitis, risk; equally raises may lessen risk. This observation warrants confirmation through additional large-scale, prospective cohort sufficient sample sizes extended follow-up durations.

Language: Английский

Citations

1
Association between the Composite Dietary Antioxidant Index and Nonalcoholic Fatty Liver Disease: Evidence from National Health and Nutrition Examination Survey 2005-2016 DOI Creative Commons

Yidian Fu,

Chao Jiang, Zonglin Li

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 3, 2024

Abstract Importance: Oxidative stress is an important contributor to the progression of nonalcoholic fatty liver disease (NAFLD), however, relationship between Composite Dietary Antioxidant Index (CDAI) and NAFLD in US adult population remains unclear. Objective: To access whether CDAI associated with adults. Design, setting, participants: This population-based cross-sectional study used data on adults from National Health Nutrition Examination Survey (NHANES) 2005-2016 cycles. Data were analyzed January February 2024. Exposures: obtained dietary intake questionnaire. Main outcomes measures: The main outcome was which defined by score (USFLI) ≥ 30. Sampling weights calculated according NHANES guidelines. Results: Among 9746 included this (mean age, 48.3 years; 4662 [47.6%] males), 3324 (33.0%) classified as having using USFLI. In fully adjusted multivariable logistic regression, negative (odds ratio [OR], 0.95; 95% CI, 0.93-0.98). Furthermore, highest quartile 34% less likely have than those lowest (OR, 0.66; 0.52-0.85). subgroup analyses, among participants who male 0.94; 0.92-0.97), without diabetes 0.93-0.97), metabolic syndrome 0.93; 0.91-0.96). addition, correlation robust sensitivity analyses that excluded potential hepatotoxic medication use 0.93-0.98), or non-Hispanic Black based hepatic steatosis index (HSI) 0.97; 0.95-0.99), unweighted analysis 0.96; 0.94-0.98). Conclusions relevance: six cycles (2005-2016) NHANES, population. association may provide a new approach explore factors affecting interventions reduce incidence NAFLD.

Language: Английский

Citations

0
Lipid metabolism disorders and albuminuria risk: insights from National Health and Nutrition Examination Survey 2001–2018 and Mendelian randomization analyses DOI Creative Commons

Yangyang Wang,

Sen Li

Renal Failure, Journal Year: 2024, Volume and Issue: 46(2)

Published: Nov. 3, 2024

Background Previous studies have revealed an underlying connection between abnormal lipid metabolism and albuminuria. We aim to investigate the causal relationship disorders risk of albuminuria from both a population genetic perspective.

Language: Английский

Citations

0
Unleashing of cytotoxic effects of thymoquinone-bovine serum albumin nanoparticles on A549 lung cancer cells DOI Creative Commons

B. Durga,

Ramachandran Vinayagam, Senthil Bakthavatchalam

et al.

Open Life Sciences, Journal Year: 2024, Volume and Issue: 19(1)

Published: Jan. 1, 2024

Abstract This research examines the cytotoxic consequences of thymoquinone-loaded bovine serum albumin nanoparticles (TQ-BSA NPs) on A549 lung cancer cell line. UV-visible (UV–Vis) spectroscopy, Fourier transform infrared spectrophotometer (FT-IR), scanning electron microscopy (SEM), and dynamic light scattering (DLS) were employed to verify biogenic TQ-BSA NPs’ size, shape, distribution. UV–Vis spectrophotometry indicated peaks at 200–300 nm, 500–600 a prominent peak 700–800 confirming presence NPs. The polydispersity index, as confirmed by DLS, solvent distribution in water, accompanied zeta potential value 126.2 ± 46.8 mV. average size NPs was be 187 8 nm SEM. reduce colony formation line dose-dependent manner relative control group. Protein expression analysis that promoted programmed death increasing pro-apoptotic levels decreasing anti-apoptotic levels. demonstrated inhibition proliferation promotion apoptosis exhibited significant efficacy against cells low concentrations. As result, they have makings promising chemotherapeutic agent for low-dose, long-term administration.

Language: Английский

Citations

0
Lifestyle Factors and Associations with Individual and Comorbid Cardiometabolic and Pulmonary Disease Among U.S. Adults DOI Open Access
Osayande Agbonlahor, Delvon T. Mattingly,

Maggie K. Richardson

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2024, Volume and Issue: 21(12), P. 1674 - 1674

Published: Dec. 16, 2024

Background: Although lifestyle factors have been linked to chronic diseases among adults, their association with diagnosed individual and comorbid cardiometabolic (CMD) pulmonary disease (PD) is not fully known. This study aimed examine the associations between CMD PD U.S. adults. Methods: We used cross-sectional data from 2017–2020 National Health Nutrition Examination Survey (n = 7394). care provider’s diagnosis of (i.e., past 5-day tobacco use, 12-month alcohol diet, sleep troubles, physical activity) were assessed. Adjusted odds ratios estimated using logistic multinomial regression. Results: Trouble sleeping was associated increased (OR: 2.47) 2.29) individually, while activity lower 0.75, OR: 0.77). Past 2.36) year 1.61) use odds. Lifestyle PD. Conclusions: prevention should involve promoting modification implementation policies that eliminate structural barriers healthy adoption.

Language: Английский

Citations

0