Co-selection for antibiotic resistance by environmental contaminants

npj Antimicrobials and Resistance, Journal Year: 2024, Volume and Issue: 2(1)

Published: April 1, 2024

The environment is increasingly recognised as a hotspot for the selection and dissemination of antibiotic resistant bacteria resistance genes. These can be selected by antibiotics non-antibiotic agents (such metals biocides), with evidence to support this well established observational experimental studies. However, there emerging suggest that plant protection products herbicides), drugs chemotherapeutic agents), also co-select resistance. This review aims provide an overview four classes (metals, biocides, products, drugs) how they may resistance, particular focus on environment. It identify key knowledge gaps should addressed in future work, better understand these potential co-selective agents.

Language: Английский

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Augmented dissemination of antibiotic resistance elicited by non-antibiotic factors

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 262, P. 115124 - 115124

Published: June 15, 2023

The emergence and rapid spread of antibiotic resistance seriously compromise the clinical efficacy current therapies, representing a serious public health threat worldwide. Generally, drug-susceptible bacteria can acquire through genetic mutation or gene transfer, among which horizontal transfer (HGT) plays dominant role. It is widely acknowledged that sub-inhibitory concentrations antibiotics are key drivers in promoting transmission resistance. However, accumulating evidence recent years has shown addition to antibiotics, non-antibiotics also accelerate genes (ARGs). Nevertheless, roles potential mechanisms non-antibiotic factors ARGs remain largely underestimated. In this review, we depict four pathways HGT their differences, including conjugation, transformation, transduction vesiduction. We summarize accounting for enhanced underlying molecular mechanisms. Finally, discuss limitations implications studies.

Language: Английский

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Comprehensive insights into antibiotic resistance gene migration in microalgal-bacterial consortia: Mechanisms, factors, and perspectives

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 901, P. 166029 - 166029

Published: Aug. 2, 2023

Language: Английский

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Investigation of the impact of widely used pesticides on conjugative transfer of multidrug resistance plasmids

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 478, P. 135436 - 135436

Published: Aug. 5, 2024

Language: Английский

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Current and Future Flow Cytometry Applications Contributing to Antimicrobial Resistance Control

Microorganisms, Journal Year: 2023, Volume and Issue: 11(5), P. 1300 - 1300

Published: May 16, 2023

Antimicrobial resistance is a global threat to human health and welfare, food safety, environmental health. The rapid detection quantification of antimicrobial are important for both infectious disease control public assessment. Technologies such as flow cytometry can provide clinicians with the early information, they need appropriate antibiotic treatment. At same time, platforms facilitate measurement antibiotic-resistant bacteria in environments impacted by activities, enabling assessment their impact on watersheds soils. This review focuses latest applications pathogens clinical samples. Novel susceptibility testing frameworks embedding assays contribute implementation surveillance systems that needed science-based decisions actions.

Language: Английский

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Regulation of intracellular process by two-component systems: Exploring the mechanism of plasmid-mediated conjugative transfer

Water Research, Journal Year: 2024, Volume and Issue: 259, P. 121855 - 121855

Published: May 31, 2024

Language: Английский

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Mechanisms Underlying the Overlooked Chiral Fungicide-Driven Enantioselective Proliferation of Antibiotic Resistance in Earthworm Intestinal Microbiome

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(6), P. 2931 - 2943

Published: Feb. 2, 2024

From a "One Health" perspective, the global threat of antibiotic resistance genes (ARGs) is associated with modern agriculture practices including agrochemicals application. Chiral fungicides account for considerable proportion wildly used agrochemicals; however, whether and how their enantiomers lead to differential proliferation in agricultural environments remain overlooked. Focused on soil-earthworm ecosystem, we first time deciphered mechanisms underlying enantioselective driven by typical chiral fungicide mandipropamid (i.e., R-MDP S-MDP) utilizing multiomic approach. Time-series metagenomic analysis revealed that led significant enhancement ARGs potential mobility (particularly plasmid-borne ARGs) earthworm intestinal microbiome. We further demonstrated induced concentration-dependent facilitation plasmid-mediated ARG transfer among microbes. In addition, transcriptomic verification identified key aspects involved, where enhanced cell membrane permeability, ability, biofilm formation quorum sensing, rebalanced energy production, decreased versus S-MDP. Overall, findings provide novel insights into disruption microbiome resistome gut offer contributions comprehensive risk assessment agroecosystems.

Language: Английский

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The role of water matrix on antibiotic resistance genes transmission in substrate layer from stormwater bioretention cells

Water Research, Journal Year: 2024, Volume and Issue: 251, P. 121103 - 121103

Published: Jan. 3, 2024

Language: Английский

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The Overlooked Risk of Horizontal Transfer of Plasmid-Borne Antibiotic Resistance Genes Induced by Synthetic Phenolic Antioxidants

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 488, P. 137459 - 137459

Published: Feb. 1, 2025

Language: Английский

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Mangrove Plastisphere as a Hotspot for High-Risk Antibiotic Resistance Genes and Pathogens

Environmental Research, Journal Year: 2025, Volume and Issue: 274, P. 121282 - 121282

Published: March 4, 2025

Language: Английский

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