Small Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 21, 2024
Microneedles
(MNs)
have
emerged
as
a
promising
transdermal
antimicrobial
delivery
system,
providing
precise
and
localized
drug
while
complemented
with
noninvasiveness
patient
compliance.
Currently,
the
topical
application
of
antimicrobials
restricts
drugs
to
critical
areas
wound
bed,
largely
due
barriers
posed
by
necrotic
tissue,
scab
formation,
bacterial
biofilms,
which
severely
diminish
bioavailability
therapeutics.
MNs
enabled
efficient
targeted
overcome
many
chronic
challenges.
Over
past
decade,
significant
progress
has
been
made
develop
unique
properties
tailored
for
vaccines,
anticancer,
antimicrobials.
As
ongoing
research
continues
refine
MN
design,
material
properties,
formulations,
potential
revolutionizing
efficacy,
experience,
therapeutic
outcomes
remains
at
forefront
scientific
research.
In
this
review,
insights
are
provided
into
latest
progress,
current
developments,
diverse
applications
delivery.
Herein,
translational
is
highlighted
perspective
on
challenges
associated
clinical
translation
provided.
Furthermore,
review
aids
in
identifying
gaps
empowering
contributing
future
implementation
cutting‐edge
systems
effectively
tackle
resistance.
Gels,
Journal Year:
2024,
Volume and Issue:
10(1), P. 43 - 43
Published: Jan. 5, 2024
The
care
and
rehabilitation
of
acute
chronic
wounds
have
a
significant
social
economic
impact
on
patients
global
health.
This
burden
is
primarily
due
to
the
adverse
effects
infections,
prolonged
recovery,
associated
treatment
costs.
Chronic
can
be
treated
with
variety
approaches,
which
include
surgery,
negative
pressure
wound
therapy,
dressings,
hyperbaric
oxygen
therapy.
However,
each
these
strategies
has
an
array
limitations.
existing
dry
dressings
lack
functionality
in
promoting
healing
exacerbating
pain
by
adhering
wound.
Hydrogels,
are
commonly
polymer-based
swell
water,
been
proposed
as
potential
remedies
their
ability
provide
moist
environment
that
facilitates
healing.
Their
unique
composition
enables
them
absorb
exudates,
exhibit
shape
adaptability,
modified
incorporate
active
compounds
such
growth
factors
antibacterial
compounds.
review
provides
updated
discussion
leading
natural
synthetic
hydrogels
utilized
healing,
details
latest
advancements
hydrogel
technology,
explores
alternate
approaches
this
field.
Search
engines
Scopus,
PubMed,
Science
Direct,
Web
were
advances
applications
over
last
fifteen
years.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(2), P. 1498 - 1498
Published: Jan. 12, 2023
The
skin
is
the
main
barrier
between
body
and
environment,
protecting
it
from
external
oxidative
stress
induced
by
ultraviolet
rays.
It
also
prevents
entrance
of
infectious
agents
such
as
viruses,
antigens,
allergens,
bacteria
into
our
bodies.
An
overreaction
to
these
causes
severe
diseases,
including
atopic
dermatitis,
pruritus,
psoriasis,
cancer,
vitiligo.
Members
flavonoid
family
include
apigenin,
quercetin,
luteolin,
kaempferol.
Of
these,
apigenin
has
been
used
a
dietary
supplement
due
its
various
biological
activities
shown
reduce
inflammation
downregulating
inflammatory
markers
molecular
targets.
In
this
review,
we
deal
with
current
knowledge
about
reactions
in
mechanisms
which
reduces
inflammation.
Gels,
Journal Year:
2023,
Volume and Issue:
9(7), P. 539 - 539
Published: July 3, 2023
Aloe
vera-based
hydrogels
have
emerged
as
promising
platforms
for
the
delivery
of
therapeutic
agents
in
wound
dressings
due
to
their
biocompatibility
and
unique
wound-healing
properties.
The
present
study
provides
a
comprehensive
overview
recent
advances
application
healing.
synthesis
methods,
structural
characteristics,
properties
are
discussed.
Mechanisms
released
from
hydrogels,
including
diffusion,
swelling,
degradation,
also
analyzed.
In
addition,
effects
on
healing,
well
reduction
inflammation,
antimicrobial
activity,
tissue
regeneration,
highlighted.
incorporation
various
agents,
such
anti-inflammatory
ones,
into
is
reviewed
detail.
Furthermore,
challenges
future
prospects
dressing
applications
considered.
This
review
valuable
information
current
status
highlights
potential
improve
healing
outcomes.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(7), P. 3790 - 3790
Published: March 28, 2024
Cutaneous
wound
healing
is
a
complex
biological
process
involving
series
of
well-coordinated
events
aimed
at
restoring
skin
integrity
and
function.
Various
experimental
models
have
been
developed
to
study
the
mechanisms
underlying
repair
evaluate
potential
therapeutic
interventions.
This
review
explores
diverse
array
utilized
in
research,
ranging
from
rodent
excisional
wounds
advanced
tissue
engineering
constructs
microfluidic
platforms.
More
importantly,
influence
lipids
on
examined,
emphasizing
their
role
enhancing
barrier
function
restoration,
modulating
inflammation,
promoting
cell
proliferation,
remodeling.
Lipids,
such
as
phospholipids,
sphingolipids,
ceramides,
play
crucial
roles
membrane
structure,
signaling,
repair.
Understanding
interplay
between
microenvironment
provides
valuable
insights
into
development
novel
strategies
for
efficient
regeneration.
highlights
significance
investigating
elucidating
intricate
involvement
process,
offering
avenues
improving
clinical
outcomes
management.
Frontiers in Bioscience-Landmark,
Journal Year:
2025,
Volume and Issue:
30(1)
Published: Jan. 20, 2025
Human
skin
is
a
physical
and
biochemical
barrier
that
protects
the
internal
body
from
external
environment.
Throughout
person’s
life,
undergoes
both
intrinsic
extrinsic
aging,
leading
to
microscopic
macroscopic
changes
in
its
morphology.
In
addition,
repair
processes
slow
with
making
older
population
more
susceptible
diseases.
Intrinsic
factors
associated
advanced
age
gradually
degrade
dermal
collagen
matrix,
resulting
fine
wrinkles
reduced
elasticity;
this
accelerated
post-menopausal
women
due
estrogen
deficiency.
contrast,
age,
primarily
caused
by
exposure
ultraviolet
(UV)
radiation,
lead
coarse
wrinkles,
solar
elastosis,
hyperkeratosis,
irregular
pigmentation,
cancers.
UVB
while
contributing
photo-aging,
also
induces
cutaneous
synthesis
of
vitamin
D.
Vitamin
D,
turn,
oxidative
stress,
inflammation,
DNA
damage,
thereby
delaying
chronological
photo-aging.
Moreover,
research
has
demonstrated
an
association
between
lower
D
levels
higher
prevalence
certain
This
review
explores
summarizes
critical
role
aging
age-related
The
data
presented
highlight
importance
maintaining
adequacy
throughout
life.
Advanced Science,
Journal Year:
2021,
Volume and Issue:
8(10)
Published: March 11, 2021
Abstract
Three‐dimensional
(3D)
bioprinting
is
an
emerging,
groundbreaking
strategy
in
tissue
engineering,
allowing
the
fabrication
of
living
constructs
with
unprecedented
degree
complexity
and
accuracy.
While
this
technique
greatly
facilitates
structuring
native
tissue‐like
architectures,
many
challenges
still
remain
to
be
faced.
In
review,
fruits
recent
research
that
demonstrate
how
advanced
technologies,
together
inspiring
creativity,
can
used
address
these
are
presented
discussed.
Next,
future
field
discussed,
terms
expected
developments,
as
well
possible
directions
toward
realization
vision
fully
functional,
engineered
tissues,
organs.
Last,
a
few
hypothetical
scenarios
for
role
3D
may
play
engineering
depicted,
emphasis
on
its
impact
tomorrow's
regenerative
medicine.
