Cancer and the Microbiome of the Human Body

Nutrients, Journal Year: 2024, Volume and Issue: 16(16), P. 2790 - 2790

Published: Aug. 21, 2024

Cancer remains a public health concern worldwide, with its incidence increasing worldwide and expected to continue growing during the next decades. The microbiome has emerged as central factor in human disease, demonstrating an intricate relationship between cancer. Although some microbiomes present within local tissues have been shown restrict cancer development, mainly by interacting cells or host immune system, microorganisms are harmful risk factors for development. This review summarizes recent evidence concerning of most common types (i.e., lung, head neck, breast, gastric, colorectal, prostate, cervix cancers), providing general overview future clinical approaches perspectives.

Language: Английский

---

Characteristics and function of the gut microbiota in patients with rectal neuroendocrine tumors

Journal of Cancer, Journal Year: 2025, Volume and Issue: 16(4), P. 1040 - 1050

Published: Jan. 1, 2025

The gut microbiota plays a significant role in the initiation and progression of tumors, but its rectal neuroendocrine tumors (rNETs) remains unclear. Fecal samples were collected from 19 healthy individuals 21 rNET patients,with cohort further divided into metastatic (rNETs-M) non-metastatic (rNETs-nM) groups. Using metagenomic high-throughput sequencing, we analyzed diversity, species composition, functional characteristics microbiota. We applied random forest model to identify potential microbial biomarkers for predicting specifically distinguishing rNETs-M cases. Alpha diversity analysis revealed that was lower rNETs group than control group. In contrast, exhibited higher rNETs-nM Beta demonstrated differences community structure between groups rNET-M Notably, group, abundance pathogens such as Escherichia coli Shigella elevated.Furthermore, an increased Alistipes. KEGG enrichment indicated these distinct play environmental information processing, genetic metabolic pathways. Random ROC curve results identified Lachnospira pectinoschiza (AUC=0.885), Parasutterella muris (AUC=0.862), Sodaliphilus pleomorphus(AUC=0.956), Methylobacterium iners (AUC=0.971) with discriminatory value.

Language: Английский

---

Community characteristics and relationship between gut microbiota and intratumoral microbiota in hepatocellular carcinoma

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 10, 2025

The combination of local therapy with lenvatinib and programmed cell death protein-1 (PD-1) inhibitors represents an emerging treatment paradigm for unresectable hepatocellular carcinoma (uHCC). Our study sought to investigate the interrelationship between gut microbiota intratumoral in context triple therapy, a view identifying potential biological markers. microbial community profiles patients primary untreated (HCC) those treated combined PD-1 were analyzed by 16S rRNA gene amplicon sequencing. Additionally, tumor tissues HCC normal liver analyzed. In our investigation, we observed that who received exhibited notable enhancement abundance Actinobacteriota considerable decrease Escherichia Shigella. Patients hepatic artery infusion chemotherapy (HAIC) levatinib significantly elevated levels Faecalibacterium prausnitzii Bacteroides stercoris comparison transarterial chemoembolization (TACE) inhibitors. Furthermore, decline diversity was within tumors tissues. high degree similarity microbes present at phylum level. Gut is connected HCC. These discoveries underscore utilizing as biomarkers, well possibility management

Language: Английский

---

Research progress on intratumoral microorganisms in renal cancer

World Journal of Urology, Journal Year: 2025, Volume and Issue: 43(1)

Published: Jan. 15, 2025

Language: Английский

---

Tumor and intratumoral pathogen cascade-targeting photothermal nanotherapeutics for boosted immunotherapy of colorectal cancer

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 574 - 591

Published: Jan. 24, 2025

Language: Английский

---