Tertiary lymphoid structure formation: A matter of tumor-immune co-evolution DOI
Anne M. van der Leun

Molecular Immunology, Journal Year: 2024, Volume and Issue: 175, P. 143 - 145

Published: Oct. 9, 2024

Language: Английский

Single-cell technologies: current and near future DOI Creative Commons

Chenfei Wang,

Qi Liu, Xiaohui Fan

et al.

Science China Life Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Language: Английский

Citations

1
Macrophages and tertiary lymphoid structures as indicators of prognosis and therapeutic response in cancer patients DOI

Li Niu,

Ting Chen,

Aodan Yang

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: 1879(5), P. 189125 - 189125

Published: June 6, 2024

Language: Английский

Citations

0
Analyzing the Spatial Distribution of Immune Cells in Lung Adenocarcinoma DOI Open Access
Florina Almarii, Maria Sajin,

George Simion

et al.

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(9), P. 925 - 925

Published: Aug. 30, 2024

(1) Background: This study investigates the tumor immune microenvironment, focusing on cell distribution in lung adenocarcinoma. (2) Methods: We evaluated fifty cases of adenocarcinoma, and suitable areas for further studies were annotated histological slides. Two cores per case obtained, one from tumor's center another its periphery, introduced into three paraffin receptor blocks optimized processing efficiency. The 4-micrometer-thick tissue microarray sections stained H&E CD68, CD163, CD8, CD4, PD-L1; (3) Results: Our investigation revealed significant correlations between PD-L1 expression cells presence CD163+ macrophages, CD4+ CD8+, CD68+, cells, also CD8+ T cells. Additionally, while we observed some differences cellular components densities these not statistically significant. However, distinct regions identified, suggesting spatial heterogeneity landscape. (4) Conclusions: These results emphasize intricate interactions Understanding patient profile could improve selection immunotherapy, ensuring that those most likely to benefit are identified.

Language: Английский

Citations

0
Powerful microscopy technologies decode spatially organized cellular networks that drive response to immunotherapy in humans DOI
Jonathan H. Chen, Liad Elmelech,

Alexander L. Tang

et al.

Current Opinion in Immunology, Journal Year: 2024, Volume and Issue: 91, P. 102463 - 102463

Published: Sept. 14, 2024

Language: Английский

Citations

0
Tertiary lymphoid structure formation: A matter of tumor-immune co-evolution DOI
Anne M. van der Leun

Molecular Immunology, Journal Year: 2024, Volume and Issue: 175, P. 143 - 145

Published: Oct. 9, 2024

Language: Английский

Citations

0