Intelligent fiber-based sensors for continuous monitoring of levodopa concentration and real-time Parkinson management DOI
Dawei Zhou, Meng Yin, Chenyu Wang

et al.

Nano Today, Journal Year: 2024, Volume and Issue: 61, P. 102613 - 102613

Published: Dec. 27, 2024

Language: Английский

A positive allosteric modulator of α7 nicotinic receptor reduces levodopa-induced dyskinesias in hemi-parkinsonian mice DOI

Alejandra Gómez-Paz,

Vladimir Calderón,

Aldo Luna-Leal

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177655 - 177655

Published: April 1, 2025

Language: Английский

Citations

0
Subregion-specific suppression of dopamine D1 receptor expression prevents L-DOPA-induced dyskinesia in a mouse model of Parkinson’s disease DOI

Keita Sugiyama,

Mahomi Kuroiwa,

Takahide Shuto

et al.

Neuroscience Letters, Journal Year: 2025, Volume and Issue: unknown, P. 138273 - 138273

Published: May 1, 2025

Language: Английский

Citations

0
A Convergent Pathway for Stimulation‐Induced Dyskinesia Following Deep Brain Stimulation DOI Creative Commons
Joshua K. Wong, Andreas Horn, Erik H. Middlebrooks

et al.

Movement Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: May 29, 2025

Abstract Background Stimulation‐induced dyskinesias (SID) from deep brain stimulation (DBS) of the subthalamic nucleus (STN) and globus pallidus internus (GPi) are uncommon; however, they increasingly recognized. Once considered transient indicative effective neuromodulation, SID now seen as potential therapy‐limiting side effects, akin to internal capsule activation. The mechanism anatomical basis for remain poorly understood. Methods We conducted a retrospective study individuals with Parkinson's disease STN or GPi DBS who experienced in dopaminergic medication OFF state during monopolar review 1‐month post‐implantation. Results analyzed 137 observations (105 GPi, 32 STN). In cohort, discriminative fiber tract analysis showed strong association between modulation subthalamo‐pallidal fibers. This correlation was confirmed using leave‐one‐out five‐fold cross‐validation. further validated this model by predicting independent cohorts, GPi‐based accounting significant variance occurrence both cohorts. Conclusions likely shares common pathway via connectivity. these fibers correlates SID, multiple cross‐validation methods. These findings suggest that part more extensive yet‐to‐be‐fully‐characterized dyskinesia network. © 2025 Author(s). Movement Disorders published Wiley Periodicals LLC on behalf International Parkinson Disorder Society.

Language: Английский

Citations

0
LDHzyme-assisted high-performance on-site tracking of levodopa pharmacokinetics for Parkinson’s disease management DOI
Dawei Zhou, Meng Yin,

Yun Shen

et al.

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 268, P. 116926 - 116926

Published: Nov. 9, 2024

Language: Английский

Citations

1
Intelligent fiber-based sensors for continuous monitoring of levodopa concentration and real-time Parkinson management DOI
Dawei Zhou, Meng Yin, Chenyu Wang

et al.

Nano Today, Journal Year: 2024, Volume and Issue: 61, P. 102613 - 102613

Published: Dec. 27, 2024

Language: Английский

Citations

0