The impact of microplastics on antibiotic resistance genes, metal resistance genes, and bacterial community in aquaculture environment

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 489, P. 137704 - 137704

Published: Feb. 20, 2025

Language: Английский

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Microplastics storage at the sediment-water interface in a gravel-bed river: importance of local hydro-sedimentary conditions in downwelling, upwelling, and sedimentation zones

Water Research, Journal Year: 2025, Volume and Issue: 279, P. 123433 - 123433

Published: March 4, 2025

Language: Английский

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Characteristics and influencing factors of microplastics entering human blood through intravenous injection

Environment International, Journal Year: 2025, Volume and Issue: unknown, P. 109377 - 109377

Published: March 1, 2025

The presence of microplastics in the human body and their potential health risks have drawn widespread attention recent years. Microplastics been detected blood, though pathways entry remain unclear. This study employed Raman spectroscopy energy dispersive to evaluate microplastic release characteristics intravenous medical devices, aiming investigate influencing factors risk entering bloodstream. results showed that were found three widely-used with abundances ranging from 0.44 2.00 items/n. Polyethylene, polypropylene (46.2 %), fragments (96.7 white (86.8 %) predominant characteristics. Factors such as brand, specifications, usage scenarios influence release, leading differences detection rates among different devices (0-100%). Repeated use significantly increases (p < 0.05). Notably, built-in filtration membranes do not completely retain may pose a shedding fibers themselves. Using exposure assessment model, estimated per person year was 3.75 items for syringe, 6.22 infusion set, 0.35 vein detained needle. Overall, although amount through injection is lower than dietary other pathways, direct into bloodstream remains concern. research provides critical evidence understanding blood plastic offering significant scientific value assessing safety device use.

Language: Английский

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Impact of Persistent Endocrine-Disrupting Chemicals on Human Nuclear Receptors: Insights from In Silico and Experimental Characterization

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2879 - 2879

Published: March 21, 2025

Endocrine-disrupting chemicals (EDCs) are notable for their persistence, bioaccumulation, and associations with cancer. Human nuclear receptors (hNRs) primary targets disrupted by these persistent EDCs, resulting in alterations to xenobiotic metabolism, lipid homeostasis, endocrine function, which can lead carcinogenic effects. Despite hazardous effects, comprehensive studies on EDC interactions impacts hNRs remain limited. Here, we profiled the of including PFAS, plastic additives, bisphenols, polybrominated diphenyl ethers, phthalates, key such as PXR, CAR, PPARα, PPARγ, PPARδ, AR, RORγt. Through controlled molecular docking simulations, observed strong binding EDCs receptors. Further analysis showed that exhibit activity towards preferentially interacting hydrophobic amino acids, namely leucine, isoleucine, methionine, phenylalanine. PFAS demonstrated highest affinity, characterized a combination complementary from fluorinated carbon chains polar functional groups (e.g., carboxylate, sulfonate) across all Distinct polycyclic trends, contributing NR binding, were evident non-PFAS nonplastic EDCs. The hNR assay HepG2 cells revealed agonistic effects dicyclohexyl phthalate (DCHP) di-2-ethylhexyl (DEHP) most receptors, except PPARα. transcription factor pathway increased gene expression VDRE suggesting potential chronic metabolism calcium homeostasis. Overall, our findings demonstrate need further research into disruption

Language: Английский

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Microplastics accumulate in all major organs of the Mediterranean loggerhead sea turtle (Caretta caretta).

Marine Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 107100 - 107100

Published: March 1, 2025

Language: Английский

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Leveraging Biocatalyst-H₂O₂-Driven Microplastic Degradation: Waterborne Microplastic Breakdown and Soil Microbial Community Shifts

ACS ES&T Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Language: Английский

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Drinking Water Network as a Potential Pathway for Micro- and Nanoplastics Exposure to Human: A Mini Review

Water, Journal Year: 2025, Volume and Issue: 17(8), P. 1188 - 1188

Published: April 15, 2025

The risk of human exposure to micro- and nanoplastics (MNPs) has received increasing attention in recent years. Consumption drinking water is a significant route MNPs. While previous studies focus on MNPs treated wastewater or final effluent, research addressing networks (DWNs) as potential secondary sources remains sparse. However, how DWN, critical component transporting from treatment plants consumers, contributes contamination underexplored existing studies. We extracted keywords reviewed literature using bibliometric methods conducted correlation analyses, revealing four clusters: baseline detection, health assessments, nanoplastic, treatment. abundance DWN ranged 0.01 1.4 items/L. varied between 679.5 4.5 × 107 items/kg when calculated based sample mass (in scales debris). Based the shape polymer composition MNPs, strongly suspected contribute tap water. also main mechanisms for formation release pipelines, including mechanical forces, hammer effects, chemical aging. Our review highlighted current gaps MNP DWN. It will understanding contribution provide framework future monitoring efforts.

Language: Английский

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In vivo and in vitro degradation and biological toxicity studies of polyesters with varying degradation rates

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 492, P. 138196 - 138196

Published: April 17, 2025

Language: Английский

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Unveiling the Heart’s Hidden Enemy: Dynamic Insights into Polystyrene Nanoplastic-Induced Cardiotoxicity Based on Cardiac Organoid-on-a-Chip

ACS Nano, Journal Year: 2024, Volume and Issue: 18(45), P. 31569 - 31585

Published: Nov. 1, 2024

Exposure to micro- and nanoplastics (MNPs) has been implicated in potential cardiotoxicity. However, vitro models based on cardiomyocyte cell lines lack crucial cardiac characteristics, while interspecies differences animal compromise the reliability of conclusions. In addition, current research predominantly focused single-time point exposures MNPs, neglecting comparative analyses injury across early late stages. Moreover, there remains a large gap understanding susceptibility MNPs under pathological conditions. To address these limitations, this study integrated organoids (COs) organ-on-a-chip (OoC) technology develop organoid-on-a-chip (COoC), which was validated for cardiotoxicity evaluation through multiple dimensions. Based COoC, we conducted dynamic observation damage caused by short- long-term exposure polystyrene (PS-NPs). Oxidative stress, inflammation, disruption calcium ion homeostasis, mitochondrial dysfunction were confirmed as mechanisms PS-NP-induced events stages, fibrosis emerged prominent feature Notably, low-dose exacerbated myocardial infarction symptoms states, despite no significant shown healthy models. conclusion, findings further deepened our cardiotoxic effects introduced promising platform assessing

Language: Английский

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Environmental Exposure to Common Pesticide Induces Synaptic Deficit and Social Memory Impairment Driven by Neurodevelopmental Vulnerability of Hippocampal Parvalbumin Interneurons

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 485, P. 136893 - 136893

Published: Dec. 17, 2024

Language: Английский

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