Effect of obesity on the acute response to SARS-CoV-2 infection and development of post-acute sequelae of COVID-19 (PASC) in nonhuman primates

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Abstract Long-term adverse consequences of SARS-CoV-2 infection, termed “long COVID” or post-acute sequelae COVID (PASC), are a major component overall COVID-19 disease burden. Prior obesity and metabolic increase the severity acute disease, but infection also contributes to development new-onset disease. Since pandemic occurred in context global epidemic, an important question is extent which pre-existing modifies long-term responses infection. We utilized nonhuman primate model compare effects with delta variant lean obese/insulin-resistant adult male rhesus macaques over 6-month time course. While some longitudinal including viral dynamics, SARS-CoV-2-specific IgG induction, cytokine profiles, tissue persistence RNA, did not appreciably differ between obese animals, other responses, neutralizing Ab lung pathology, body weight, degree insulin sensitivity, adipocytokine temperature, nighttime activity levels were significantly different versus animals. Furthermore, several parameters animals altered following resemble those Notably, persistent changes multiple present most suggesting that PASC may be more prevalent than estimated from self-reported symptoms human studies.

Language: Английский

---

On the Ocean of Biomarkers for the Precise Diagnosis and Prognosis of Lung Diseases

PROTEOMICS - CLINICAL APPLICATIONS, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

ABSTRACT Bronchoalveolar lavage fluid (BALF) has long been used for diagnosing various lung diseases through its cellular components. However, the clinical utility of biomolecules in BALF remains largely unexplored. Recently, mass spectrometry‐based proteomics applied to profile proteomes identify novel biomarkers diseases. This review discusses current progress field and highlights potential as a valuable source different Additionally, we explored latest advancements findings from studies. Finally, address limitations propose future directions research opportunities advance study BALF.

Language: Английский

---

Long-Term SARS-CoV-2 Findings Related to Persisting Viral Antigen and Inflammation Resemble Those Reported for Influenza Virus and Respiratory Syncytial Virus

Viruses, Journal Year: 2024, Volume and Issue: 16(9), P. 1353 - 1353

Published: Aug. 24, 2024

Recent studies have documented prolonged expression of viral antigens and RNA associated inflammation after infection with SARS-CoV-2 in a substantial proportion infected patients. The persisting effects findings, continued detection antigens, especially resemble those previously reported for influenza virus, as well respiratory syncytial virus (RSV). reports indicate the need improved insight into mechanisms whereby post-SARS-CoV-2 infection-related illness is apparently more common perhaps even persistent than observed other viruses.

Language: Английский

---

Alterations in the plasma proteome persist ten months after recovery from mild to moderate SARS-CoV-2 infection

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 11, 2024

Limited data are available describing the effects of SARS-CoV-2 breakthrough infections on plasma proteome.

Language: Английский

---