Immunologic and Biophysical Features of the BNT162b2 JN.1- and KP.2-Adapted COVID-19 Vaccines DOI Creative Commons
Wei J. Chen, Kristin Tompkins,

I. Windsor

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

ABSTRACT Vaccines remain a vital public health tool to reduce the burden of COVID-19. COVID-19 vaccines that are more closely matched circulating SARS-CoV-2 lineages elicit potent and relevant immune responses translate improved real-world vaccine effectiveness. The rise in prevalence Omicron JN.1 lineage, subsequent derivative sublineages such as KP.2 KP.3, coincided with reduced neutralizing activity effectiveness XBB.1.5-adapted vaccines. Here, we characterized biophysical immunologic attributes BNT162b2 JN.1- KP.2-adapted mRNA vaccine-encoded spike (S) protein immunogens. Biophysical interrogations S revealed structural consequences hallmark amino acid substitutions potential molecular mechanism escape employed by KP.2. candidates were evaluated for their immunogenicity when administered fourth or fifth doses BNT162b2-experienced mice primary series naïve mice. In both vaccine-experienced settings, conferred over XBB.1.5 against broad panel emerging sublineages, including predominant KP.3.1.1 XEC lineages. Antigenic mapping indicated greater antigenic overlap currently compared an vaccine. CD4 + CD8 T cell generally conserved across all three Together, data support selection 2024-25 formula. ONE-SENTENCE SUMMARY encoding prefusion proteins similar preclinical antibody sublineage pseudoviruses than those elicited past iterations licensed vaccines, thus demonstrating importance annual strain changes

Language: Английский

Risk of COVID-19 in Children throughout the Pandemic and the Role of Vaccination: A Narrative Review DOI Creative Commons
David J. Weber, Kanecia O. Zimmerman, Sara Y. Tartof

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(9), P. 989 - 989

Published: Aug. 29, 2024

At the beginning of coronavirus disease 2019 (COVID-19) pandemic, persons ≥65 years age and healthcare personnel represented most vulnerable groups with respect to risk infection, severe illness, death. However, as pandemic progressed, there was an increasingly detrimental effect on young children adolescents. Severe hospitalization increased over time in pediatric populations, containment measures created substantial psychosocial, educational, economic challenges for people. Vaccination against COVID-19 has been shown reduce acute respiratory syndrome 2 (SARS-CoV-2) infections outcomes populations may also help prevent spread variants concern improve community immunity. This review discusses burden throughout role transmission, impact vaccination.

Language: Английский

Citations

0
Immunologic and Biophysical Features of the BNT162b2 JN.1- and KP.2-Adapted COVID-19 Vaccines DOI Creative Commons
Wei J. Chen, Kristin Tompkins,

I. Windsor

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

ABSTRACT Vaccines remain a vital public health tool to reduce the burden of COVID-19. COVID-19 vaccines that are more closely matched circulating SARS-CoV-2 lineages elicit potent and relevant immune responses translate improved real-world vaccine effectiveness. The rise in prevalence Omicron JN.1 lineage, subsequent derivative sublineages such as KP.2 KP.3, coincided with reduced neutralizing activity effectiveness XBB.1.5-adapted vaccines. Here, we characterized biophysical immunologic attributes BNT162b2 JN.1- KP.2-adapted mRNA vaccine-encoded spike (S) protein immunogens. Biophysical interrogations S revealed structural consequences hallmark amino acid substitutions potential molecular mechanism escape employed by KP.2. candidates were evaluated for their immunogenicity when administered fourth or fifth doses BNT162b2-experienced mice primary series naïve mice. In both vaccine-experienced settings, conferred over XBB.1.5 against broad panel emerging sublineages, including predominant KP.3.1.1 XEC lineages. Antigenic mapping indicated greater antigenic overlap currently compared an vaccine. CD4 + CD8 T cell generally conserved across all three Together, data support selection 2024-25 formula. ONE-SENTENCE SUMMARY encoding prefusion proteins similar preclinical antibody sublineage pseudoviruses than those elicited past iterations licensed vaccines, thus demonstrating importance annual strain changes

Language: Английский

Citations

0