Anti-neuroinflammatory agent rhein lysinate-based self-assembled injectable hydrogel loaded with ZL006 for promoting post-stroke functional recovery

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123124 - 123124

Published: Jan. 1, 2025

Language: Английский

An emerging role of SNAREs in ischemic stroke: From pre-to post-diseases

Biochemical Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 116907 - 116907

Published: March 1, 2025

Ischemic stroke is a debilitating condition characterized by high morbidity, disability, recurrence, and mortality rates on global scale, posing significant threat to public health economic stability. Extensive research has thoroughly explored the molecular mechanisms underlying ischemic stroke, elucidating strong association between soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein receptor proteins (SNAREs) pathogenesis of this condition. SNAREs, class highly conserved involved in membrane fusion, play crucial role modulating neuronal information transmission promoting myelin formation central nervous system (CNS). Preventing SNARE complex formation, malfunctions SNARE-dependent exocytosis, altered regulation SNARE-mediated vesicle fusion are linked excitotoxicity, endoplasmic reticulum (ER) stress, programmed cell death (PCD) stroke. However, its remain unclear. This study conducts comprehensive review existing literature proteins, encompassing structure, classification, expression family, as well assembly - disassembly cycle complexes their physiological roles CNS. We examine which SNAREs contribute pathological progression associated risk factors (hypertension, hyperglycemia, dyslipidemia, atherosclerosis). Furthermore, our findings highlight promise viable target for pharmacological interventions treatment

Language: Английский

Environmental enrichment promotes functional recovery from stroke via enhancing neuroplasticity through the action of β -HB

Journal of Cerebral Blood Flow & Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: May 15, 2025

Stroke is a leading cause of adult disability worldwide, unfortunately, no drugs are clinically available to promote functional recovery after stroke. Although animal environmental enrichment recognized paradigm for promoting stroke repair, elusive mechanisms hinder its clinical translation. Here, we show that β-hydroxybutyrate (β-HB) level in the peri-infarct cortex upregulated (EE) exposure. Importantly, exogenous supplementation β-HB promotes similar extent as EE Moreover, beneficial effects on recovery, including neuroplasticity-related proteins upregulation, and structural plasticity enhancement, abolished by transporter inhibitor, AR-C155858. Intriguingly, with (R)-3-hydroxybutyl (R)-β-HB, ketone ester (KE), substantially increases lessens motor impairments. Together, our findings indicate critical substrate EE-mediated monoester drinks may serve novel strategy translate from bench bedside.

Language: Английский