Mediodorsal thalamus regulates task uncertainty to enable cognitive flexibility

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 18, 2025

The mediodorsal (MD) thalamus is a critical partner for the prefrontal cortex (PFC) in cognitive control. Accumulating evidence has shown that MD regulates task uncertainty decision making and enhance flexibility. However, computational mechanism of this process remains unclear. Here we trained biologically-constrained models to delineate mechanistic role context-dependent making. We show addition feedforward structure recurrent PFC increases robustness low cueing signal-to-noise ratio, enhances working memory, enables rapid context switching. Incorporating genetically identified thalamocortical connectivity interneuron cell types into model replicates key neurophysiological findings task-performing animals. Our reveals mechanisms geometric interpretations regulating cue switching enable makes experimentally testable predictions linking deficits with disrupted connectivity, excitation-inhibition imbalance dysfunctional inhibitory types. by which activity flexibility not fully understood. authors build incorporating Together experimental testing, circuit

Language: Английский

Developing algorithmic psychiatry via multi-level spanning computational models

Cell Reports Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 102094 - 102094

Published: April 1, 2025

Language: Английский