ACS Catalysis, Journal Year: 2024, Volume and Issue: 14(22), P. 17039 - 17045

Published: Nov. 4, 2024

Herein, we demonstrate the successful application of reductive [2 + 4] annulation in atroposelective de novo benzene ring formation. This nickel-catalyzed reaction between β-substituted α-naphthylalkynes and a biselectrophile C(sp2)–X type offers an efficient convenient method to prepare highly enantioenriched C1-symmetric axially chiral biaryls containing two preinstalled functionalities. The coupling products can be used as versatile synthetic intermediates access bidentate ligands or bifunctional organocatalysts, their utility asymmetric catalysis is also showcased this context.

Language: Английский