Biophysics Reviews, Journal Year: 2025, Volume and Issue: 6(1)
Published: March 1, 2025
The central goal of mechanobiology is to understand how the mechanical forces and material properties organelles, cells, tissues influence biological processes functions. Since first description biomolecular condensates, it was hypothesized that they obtain are tuned their functions inside cells. Thus, represent an intriguing playground for mechanobiology. idea condensates exhibit diverse adaptive highlights need different states respond external whether these responses linked physiological roles within cell. For example, liquids buffer dissipate, while solids store transmit stress, relaxation time a viscoelastic can act as frequency filter. Hence, liquid-solid transition condensate in force transmission pathway determine signals transduced in-between affecting differentiation, neuronal network dynamics, behavior stimuli. Here, we review our current understanding molecular drivers rigidity phase transitions set forth complex cellular environment. We will then summarize technical advancements were necessary insights into rich fascinating finally, highlight recent examples connection specific Our provide comprehensive summary field on cells harness regulate mechanics achieve
Language: Английский