The impact of Indigenous American-like ancestry on risk of acute lymphoblastic leukemia in Hispanic/Latino children
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 15, 2025
Abstract
Acute
lymphoblastic
leukemia
(ALL)
is
the
most
common
childhood
cancer,
with
Hispanic/Latino
children
having
a
higher
incidence
of
ALL
than
other
racial/ethnic
groups.
Genetic
variants,
particularly
ones
found
enriched
in
Indigenous
American
(IA)-like
ancestry
and
inherited
by
Hispanics/Latinos,
may
contribute
to
this
disparity.
In
study,
we
characterized
impact
IA-like
on
overall
risk
frequency
effect
size
known
alleles
large
cohort
self-reported
individuals.
We
also
performed
genome-wide
admixture
mapping
analysis
identify
potentially
novel
loci.
that
global
IA
was
positively
associated
risk,
but
association
not
significant
after
adjusting
for
socio-economic
indicators.
series
local
analyses,
uncovered
at
loci,
increasing
copies
haplotype
were
significantly
case-control
status.
Further,
had
∼1.33
times
odds
harboring
allele
compared
non-IA-like
haplotypes.
no
evidence
interaction
between
genotype
(local
or
global)
relation
risk.
Admixture
identified
signals
chromosomes
2
(2q21.2),
7
(7p12.2),
10
(10q21.2),
15
(15q22.31);
however,
only
variants
7p12.2
10q21.2
replicated
additional
cohorts.
Taken
together,
our
results
suggest
increased
be
conferred
within
ancestry,
which
can
leveraged
as
targets
new
precision
health
strategies
therapeutics.
Language: Английский
Trends and Disparities in Acute Lymphoblastic Leukemia–Related Mortality in the United States from 1999 to 2020
American Journal of Clinical Oncology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 31, 2025
Objectives:
The
incidence
of
acute
lymphoblastic
leukemia
(ALL)
shows
a
bimodal
distribution,
with
the
first
peak
in
children
under
10
years
old
and
second
adults.
It
is
imperative
to
understand
disparities
ALL-related
mortality.
Methods:
mortality
trends
United
States
from
1999
2020
were
studied
by
extracting
age-adjusted
rates
(AAMRs)
Centers
for
Disease
Control
Prevention
Wide-Ranging
Online
Data
Epidemiologic
Research
database.
Changes
AAMR
evaluated
calculating
annual
percentage
change
(APC)
average
APC
using
Joinpoint
regression.
Results:
A
total
35,056
deaths
reported.
declined
(APC:
−0.65).
Men
exhibited
higher
(0.59)
than
women
(0.43).
Hispanic
or
Latinos
highest
(0.75),
followed
non-Hispanic
(NH)
whites
(0.47),
NH
black
African
Americans
(0.37),
Asian
Pacific
Islanders
(0.35).
Among
census
regions,
West
was
observed
have
(0.59),
South
(0.49),
Midwest
Northeast
(0.45).
California
had
(0.64),
while
District
Columbia
lowest
(0.40).
Stratification
urbanization
revealed
overall
rural
areas
(0.52)
urban
(0.48).
majority
occurred
medical
facilities
(63.52%).
Conclusions:
Even
though
decrease
2020,
identified
stratified
sex,
race,
urbanization.
essential
direct
efforts
towards
high-risk
populations
ensure
across
board.
Language: Английский
Evolution, genetic diversity, and health
Nature Medicine,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 7, 2025
Language: Английский
Childhood B cell leukemia: Intercepting the paths to progression
BioEssays,
Journal Year:
2024,
Volume and Issue:
46(9)
Published: July 26, 2024
Abstract
B‐cell
Acute
Lymphoblastic
Leukemia
(B‐ALL)
is
the
most
common
pediatric
cancer,
arising
often
in
children
aged
2–5
years.
This
distinctive
age
distribution
hints
at
an
association
between
B‐ALL
development
and
disrupted
immune
system
function
during
a
susceptible
period
childhood,
possibly
triggered
by
early
exposure
to
infection.
While
cure
rates
for
childhood
surpass
90%
high‐income
nations,
survivors
suffer
from
diminished
quality
of
life
due
side
effects
treatment.
Consequently,
understanding
origins
evolution
B‐ALL,
how
prevent
this
prevalent
paramount
alleviate
substantial
health
burden.
article
provides
overview
our
current
etiology
explores
knowledge
can
inform
preventive
strategies.
Language: Английский
Ikaros Deletions among Bulgarian Patients with Acute Lymphoblastic Leukemia/Lymphoma
Stefan Lozenov,
No information about this author
Yoanna Tsoneva,
No information about this author
Georgi Nikolaev
No information about this author
et al.
Diagnostics,
Journal Year:
2024,
Volume and Issue:
14(17), P. 1953 - 1953
Published: Sept. 3, 2024
The
Language: Английский
Targeting hardship: poverty as a modifiable risk factor in childhood leukemia and lymphoma treatment
Hematology,
Journal Year:
2024,
Volume and Issue:
2024(1), P. 20 - 26
Published: Dec. 6, 2024
Racial,
ethnic,
and
socioeconomic
survival
disparities
have
been
well-demonstrated
across
population-based
clinical
trial
datasets
in
pediatric
hematologic
malignancies.
To
date,
these
analyses
relied
on
trial-collected
data
such
as
race,
ethnicity,
insurance,
zip
code.
These
exposures
serve
proxies
for
factors
structural
racism,
genetic
ancestry,
adverse
social
determinants
of
health
(SDOH).
Systematic
measurement
SDOH
needs-and
interventions
targeting
needs-are
feasible
oncology.
We
use
to
present
a
roadmap
the
next
decade
equity
research
identify
actionable
mechanisms
develop
portfolio
advance
equitable
outcomes
Language: Английский