Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Dec. 18, 2024
Peri-prosthesis
osteolysis
(PPO)
represents
the
most
severe
complication
of
total
joint
arthroplasty
(TJA)
surgery
and
imposes
primary
cause
prosthesis
failure
subsequent
revision
surgery.
Antiresorptive
therapies
are
usually
prescribed
to
treat
PPO,
especially
for
elderly
people.
Nevertheless,
efficacy
anti-osteoporotic
medications
remains
constrained.
Recent
therapeutic
strategies
promote
periprosthetic
osseointegration
by
restoring
osteoblast
function
considered
more
effective
approaches.
However,
precise
mechanism
underlying
inhibition
osteogenesis
triggered
wear
particles
enigmatic.
Herein,
we
demonstrate
that
inhibit
inducing
ferroptosis
sabotage
extracellular
mineralization
arouse
osteolysis.
The
suppression
could
significantly
rescue
thus
alleviating
PPO.
Furthermore,
Glutathione
Peroxidase
4
(GPX4)
has
been
identified
as
a
key
target
in
regulating
osteoblastic
ferroptosis.
By
utilizing
virtual
screening
techniques,
have
successfully
conducted
comprehensive
natural
compound
known
Urolithin
A
(UA),
which
exhibits
remarkable
while
simultaneously
promoting
process
through
its
targeting
on
GPX4.
Meanwhile,
UA
improves
osteolytic
conditions
vivo
even
when
adjunction
titanium
(Ti)
nanoparticles.
This
strategy
great
potential
treating
peri-prosthesis
potentially
broadens
scope
clinical
therapy.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(24), P. 13255 - 13255
Published: Dec. 10, 2024
Mucosal
immunity
plays
a
critical
role
in
the
pathogenesis
of
inflammatory
immune
diseases.
This
study
leverages
single-cell
RNA
sequencing,
spatial
transcriptomics,
and
proteomics
to
compare
cellular
mechanisms
involved
periodontitis
between
humans
mice,
aiming
develop
precise
strategies
protect
gingival
mucosal
barrier.
We
identified
key
conserved
divergent
features
landscapes
transcriptional
profiles
across
two
species,
underscoring
complexity
responses
dynamics
periodontitis.
Additionally,
we
revealed
novel
regulatory
mechanism
by
which
epithelial
cells
modulate
macrophage
behavior
inflammation
through
JAG1–Notch
pathway.
Validation
animal
experiments
that
JAG1
inhibition
reduces
cells,
mitigating
Our
findings
advance
understanding
periodontal
disease
highlight
importance
integrating
human
model
data
treatments
aligned
with
physiology,
offering
potential
therapeutic
targets
for
controlling
enhancing
tissue
regeneration.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Dec. 18, 2024
Peri-prosthesis
osteolysis
(PPO)
represents
the
most
severe
complication
of
total
joint
arthroplasty
(TJA)
surgery
and
imposes
primary
cause
prosthesis
failure
subsequent
revision
surgery.
Antiresorptive
therapies
are
usually
prescribed
to
treat
PPO,
especially
for
elderly
people.
Nevertheless,
efficacy
anti-osteoporotic
medications
remains
constrained.
Recent
therapeutic
strategies
promote
periprosthetic
osseointegration
by
restoring
osteoblast
function
considered
more
effective
approaches.
However,
precise
mechanism
underlying
inhibition
osteogenesis
triggered
wear
particles
enigmatic.
Herein,
we
demonstrate
that
inhibit
inducing
ferroptosis
sabotage
extracellular
mineralization
arouse
osteolysis.
The
suppression
could
significantly
rescue
thus
alleviating
PPO.
Furthermore,
Glutathione
Peroxidase
4
(GPX4)
has
been
identified
as
a
key
target
in
regulating
osteoblastic
ferroptosis.
By
utilizing
virtual
screening
techniques,
have
successfully
conducted
comprehensive
natural
compound
known
Urolithin
A
(UA),
which
exhibits
remarkable
while
simultaneously
promoting
process
through
its
targeting
on
GPX4.
Meanwhile,
UA
improves
osteolytic
conditions
vivo
even
when
adjunction
titanium
(Ti)
nanoparticles.
This
strategy
great
potential
treating
peri-prosthesis
potentially
broadens
scope
clinical
therapy.
