Immunomodulatory role of the stem cell circadian clock in muscle repair DOI Creative Commons
Pei Zhu,

Eric M. Pfrender,

Adam W. T. Steffeck

et al.

Science Advances, Journal Year: 2025, Volume and Issue: 11(10)

Published: March 5, 2025

Circadian rhythms orchestrate physiological processes such as metabolism, immune function, and tissue regeneration, aligning them with the optimal time of day (TOD). This study identifies an interplay between circadian clock within muscle stem cells (SCs) their capacity to modulate microenvironment during regeneration. We reveal that SC triggers TOD-dependent inflammatory gene transcription after injury, particularly genes related neutrophil activity chemotaxis. These responses are driven by cytosolic regeneration signaling metabolite nicotinamide adenine dinucleotide (oxidized form) (NAD+), enhancing NAD+ in SCs is sufficient induce influence Mononuclear single-cell sequencing regenerating niche further implicates cytokine CCL2 mediating SC-neutrophil cross-talk a manner. Our findings highlight intersection metabolic shifts microenvironment, dictated rhythms, underscore potential for targeting pathways enhance

Language: Английский

Immunomodulatory role of the stem cell circadian clock in muscle repair DOI Creative Commons
Pei Zhu,

Eric M. Pfrender,

Adam W. T. Steffeck

et al.

Science Advances, Journal Year: 2025, Volume and Issue: 11(10)

Published: March 5, 2025

Circadian rhythms orchestrate physiological processes such as metabolism, immune function, and tissue regeneration, aligning them with the optimal time of day (TOD). This study identifies an interplay between circadian clock within muscle stem cells (SCs) their capacity to modulate microenvironment during regeneration. We reveal that SC triggers TOD-dependent inflammatory gene transcription after injury, particularly genes related neutrophil activity chemotaxis. These responses are driven by cytosolic regeneration signaling metabolite nicotinamide adenine dinucleotide (oxidized form) (NAD+), enhancing NAD+ in SCs is sufficient induce influence Mononuclear single-cell sequencing regenerating niche further implicates cytokine CCL2 mediating SC-neutrophil cross-talk a manner. Our findings highlight intersection metabolic shifts microenvironment, dictated rhythms, underscore potential for targeting pathways enhance

Language: Английский

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