Salidroside Prevents Cadmium Chloride-Induced DNA Damage in Human Fetal Lung Fibroblasts DOI
Yufei Wu,

Chuan Sun

Journal of Trace Elements in Medicine and Biology, Journal Year: 2024, Volume and Issue: 86, P. 127521 - 127521

Published: Sept. 6, 2024

Language: Английский

Integrated network pharmacology, bioinformatics, and experiment analysis to decipher the molecular mechanism of Salidroside on Gastric cancer via targeting NCOA4-mediated ferritinophagy DOI
Yu Fu,

Guiqin Huang,

Yawen Cai

et al.

Chemico-Biological Interactions, Journal Year: 2025, Volume and Issue: unknown, P. 111368 - 111368

Published: Jan. 1, 2025

Language: Английский

Citations

1
Inhibition of ASIC1a reduces ferroptosis in rheumatoid arthritis articular chondrocytes via the p53/NRF2/SLC7A11 pathway DOI Creative Commons

Jie Tang,

Wenqiang Liu,

Zihan Li

et al.

The FASEB Journal, Journal Year: 2025, Volume and Issue: 39(1)

Published: Jan. 6, 2025

The activation of acid-sensing ion channel 1a (ASIC1a) in response to extracellular acidification leads an increase calcium influx, thereby exacerbating the degeneration articular chondrocytes rheumatoid arthritis (RA). It has been suggested that inhibition influx could potentially impede chondrocyte ferroptosis. cystine transporter, solute carrier family 7 member 11 (SLC7A11), is recognized as a key regulator Recent studies suggest tumor suppressor gene p53 facilitates induction ferroptosis by suppressing upregulation SLC7A11. This process mediated nuclear factor erythroid 2-related 2 (NRF2), transcription integral maintenance cellular redox homeostasis and regulation inflammatory responses. study aims investigate role ASIC1a RA determine involvement p53/NRF2/SLC7A11 pathway its underlying mechanism. In vitro experiments revealed acidosis induces reduces expression NRF2 SLC7A11 chondrocytes. Moreover, significantly increased protein levels Pifithrin-α (PFN-α), inhibitor, mitigated acidosis-induced restored diminished Furthermore, PcTx-1, inhibited acidification-induced ferroptosis, enhanced NRF2, reduced expression. vivo demonstrated ASIC1a-specific inhibitor PcTx-1 ameliorated histopathological characteristics ankle joints collagen-induced (CIA) mice, decreased expression, These findings may mitigate RA, via pathway.

Language: Английский

Citations

1
Network pharmacological analysis of Salidroside in the treatment of rectal cancer DOI
Ying Zhang

New discovery., Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: Feb. 10, 2025

Objective: This study aims to conduct a comprehensive bioinformatic analysis identify pharmacological targets in rectum tissue, rectal cancer and the effects of Salidroside. Methods: Genes associated with cancer, Salidroside were identified using MeSH retrieval from NCBI database screened GeneCards, TCMSP, HERB, ETCM databases. The overlapping genes visualized Venn diagram created on jvenn website. Protein-protein interactions (PPI), Gene Ontology (GO) analysis, Kyoto Encyclopedia Genomes (KEGG) pathway enrichment analyses performed STRING Metascape Results: Bioinformatic several key differentially expressed following treatment. A total 22 intersecting through PPI network revealed top 10 core proteins CytoHubba plugin. GO KEGG highlighted localization degree within signaling pathways. Conclusions: elucidated mechanisms underlying therapeutic providing theoretical foundation for future research.

Language: Английский

Citations

0
Salidroside: Diverse Synthetic Pathways and Recent Advances in Pharmacological Effects Across Multiple Systems DOI
Min Zhao,

Liuxiang Feng,

Wenhua Li

et al.

Pharmacological Research - Natural Products, Journal Year: 2025, Volume and Issue: unknown, P. 100176 - 100176

Published: Feb. 1, 2025

Language: Английский

Citations

0
Salidroside sensitizes Triple-negative breast cancer to ferroptosis by SCD1-mediated lipogenesis and NCOA4-mediated ferritinophagy DOI Creative Commons

Guiqin Huang,

Yawen Cai,

Menghui Ren

et al.

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

2
Sensitivity of triple negative breast cancer cells to ATM-dependent ferroptosis induced by sodium selenite DOI
Mengchen Xu,

Xu Gao,

Yue Lu

et al.

Experimental Cell Research, Journal Year: 2024, Volume and Issue: 442(2), P. 114222 - 114222

Published: Aug. 29, 2024

Language: Английский

Citations

1
Salidroside Prevents Cadmium Chloride-Induced DNA Damage in Human Fetal Lung Fibroblasts DOI
Yufei Wu,

Chuan Sun

Journal of Trace Elements in Medicine and Biology, Journal Year: 2024, Volume and Issue: 86, P. 127521 - 127521

Published: Sept. 6, 2024

Language: Английский

Citations

1