Tumor- and host-derived heparanase-2 (Hpa2) attenuates tumorigenicity: role of Hpa2 in macrophage polarization and BRD7 nuclear localization DOI Creative Commons

Soaad Soboh,

Avital Vorontsova,

Malik Farhoud

et al.

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(12)

Published: Dec. 18, 2024

Abstract Little attention was given to heparanase 2 (Hpa2) over the last two decades, possibly because it lacks a heparan sulfate (HS)-degrading activity typical of heparanase. Emerging results suggest, nonetheless, that Hpa2 plays role in human pathologies, including cancer progression where functions as tumor suppressor. Here, we examined cervical carcinoma. We report high levels correlate with prolonged survival carcinoma patients. Strong staining intensity also correlates low grade. Overexpression SiHa cells resulted xenografts were two-fold smaller than control tumors. Interestingly, even developed by overexpressing Pro140Arg and Asn543Ile missense mutations identified patients diagnosed urofacial syndrome (UFS). Utilizing Ras recruitment system, bromodomain-containing protein 7 (BRD7) interact found both BRD7 mutants are translocated cell nucleus tumors mutants. our newly conditional Hpa2-KO mice, further show critical macrophage polarization; absence Hpa2, macrophages shifted towards pro-tumorigenic, M2 phenotype. Notably, implanting together promoted growth. These support, expand, notion suppressor, co-operating another BRD7.

Language: Английский

Immune Watchdogs: Tissue-Resident Lymphocytes as Key Players in Cancer Defense DOI
Ashiq Ali,

Khadija Younas,

Aisha Khatoon

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: 208, P. 104644 - 104644

Published: Feb. 1, 2025

Language: Английский

Citations

0
The role of macrophages in liver metastasis: mechanisms and therapeutic prospects DOI Creative Commons
Qin Yuan,

Linlin Jia,

Jiahua Yang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 17, 2025

Metastasis is a hallmark of advanced cancer, and the liver common site for secondary metastasis many tumor cells, including colorectal, pancreatic, gastric, prostate cancers. Macrophages in microenvironment (TME) promote cell through various mechanisms, angiogenesis immunosuppression, play unique role development metastasis. are affected by variety factors. Under conditions hypoxia increased acidity TME, more factors now found to polarization macrophages M2 type, exosomes amino acids. M2-type secretion such as VEGF, IL-1β, TGF-β1. subjected multiple regulatory mechanisms. They also interact with cells within co-regulate certain conditions, creation an immunosuppressive microenvironment. This interaction promotes metastasis, drug resistance, immune escape. Based on advent single-cell sequencing technology, further insights into macrophage subpopulations may help exploring new therapeutic targets future. In this paper, we will focus how affect well other each other, investigate mechanisms involved their potential targets.

Language: Английский

Citations

0
Harnessing myeloid cells in cancer DOI Creative Commons
Suyeon Park, Ekaterina Pylaeva, Vikas Bhuria

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 6, 2025

Cancer-associated myeloid cells due to their plasticity play dual roles in both promoting and inhibiting tumor progression. Myeloid with immunosuppressive properties a critical role anti-cancer immune regulation. Cells of different origin, such as associated macrophages (TAMs), neutrophils (TANs), derived suppressor (also called MDSCs) eosinophils are often expanded cancer patients significantly influence survival, but also the outcome therapies. For this reason, variety preclinical clinical studies modulate activity these have been conducted, however without successful date. In review, pro-tumor cells, cell-specific therapeutic targets, vivo on cell re-polarization impact immunotherapies/genetic engineering addressed. This paper summarizes ongoing trials concept chimeric antigen receptor macrophage (CAR-M) therapies, suggests future research perspectives, offering new opportunities development novel treatment strategies.

Language: Английский

Citations

0
Mannose modified graphene oxide drug-delivery system targets cancer stem cells and tumor-associated macrophages to promote immunotherapeutic efficacy DOI
Jiapu Wang, Ziwei Liang, Yuhui Wang

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114710 - 114710

Published: April 1, 2025

Language: Английский

Citations

0
Progress in modifying and delivering mRNA therapies for cancer immunotherapy DOI

Karan Goel,

Isha Chawla,

Garima Garima

et al.

Advances in immunology, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Citations

0
Tumor- and host-derived heparanase-2 (Hpa2) attenuates tumorigenicity: role of Hpa2 in macrophage polarization and BRD7 nuclear localization DOI Creative Commons

Soaad Soboh,

Avital Vorontsova,

Malik Farhoud

et al.

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(12)

Published: Dec. 18, 2024

Abstract Little attention was given to heparanase 2 (Hpa2) over the last two decades, possibly because it lacks a heparan sulfate (HS)-degrading activity typical of heparanase. Emerging results suggest, nonetheless, that Hpa2 plays role in human pathologies, including cancer progression where functions as tumor suppressor. Here, we examined cervical carcinoma. We report high levels correlate with prolonged survival carcinoma patients. Strong staining intensity also correlates low grade. Overexpression SiHa cells resulted xenografts were two-fold smaller than control tumors. Interestingly, even developed by overexpressing Pro140Arg and Asn543Ile missense mutations identified patients diagnosed urofacial syndrome (UFS). Utilizing Ras recruitment system, bromodomain-containing protein 7 (BRD7) interact found both BRD7 mutants are translocated cell nucleus tumors mutants. our newly conditional Hpa2-KO mice, further show critical macrophage polarization; absence Hpa2, macrophages shifted towards pro-tumorigenic, M2 phenotype. Notably, implanting together promoted growth. These support, expand, notion suppressor, co-operating another BRD7.

Language: Английский

Citations

0