Effectiveness of Extracellular Vesicle Application in Skin Aging Treatment and Regeneration: Do We Have Enough Evidence from Clinical Trials? DOI Open Access
Anna Domaszewska-Szostek, Marta Krzyżanowska, Agnieszka Polak

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2354 - 2354

Published: March 6, 2025

In recent years, there has been a dynamic development in therapies utilizing extracellular vesicles (EVs) including exosomes. Therefore, we have conducted an analysis of the scientific literature to verify current state knowledge about these therapies. A total 12 clinical studies were analyzed, covering use EVs treating skin aging, acne scars, alopecia, and wound healing. The results indicate that exosomes hold potential regenerative therapies, offering innovative non-invasive therapeutic approaches. At same time, significant challenges related standardization their production lack large-scale randomized identified. Thus, also evaluated investigated trials regard MISEV (Minimal Information for Studies Extracellular Vesicles) criteria. This review provides comprehensive overview contemporary applications therapy medicine, highlighting directions further research.

Language: Английский

Effectiveness of Extracellular Vesicle Application in Skin Aging Treatment and Regeneration: Do We Have Enough Evidence from Clinical Trials? DOI Open Access
Anna Domaszewska-Szostek, Marta Krzyżanowska, Agnieszka Polak

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2354 - 2354

Published: March 6, 2025

In recent years, there has been a dynamic development in therapies utilizing extracellular vesicles (EVs) including exosomes. Therefore, we have conducted an analysis of the scientific literature to verify current state knowledge about these therapies. A total 12 clinical studies were analyzed, covering use EVs treating skin aging, acne scars, alopecia, and wound healing. The results indicate that exosomes hold potential regenerative therapies, offering innovative non-invasive therapeutic approaches. At same time, significant challenges related standardization their production lack large-scale randomized identified. Thus, also evaluated investigated trials regard MISEV (Minimal Information for Studies Extracellular Vesicles) criteria. This review provides comprehensive overview contemporary applications therapy medicine, highlighting directions further research.

Language: Английский

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