The Influence of Adverse Childhood Experiences in Pain Management: Mechanisms, Processes, and Trauma-Informed Care

Frontiers in Pain Research, Journal Year: 2022, Volume and Issue: 3

Published: June 10, 2022

Adverse childhood experiences (ACEs) increase the likelihood of reduced physical and psychological health in adulthood. Though understanding management traumatic is growing, empirical exploration ACEs clinical outcomes remains under-represented under-explored. This topical review aimed to highlight role experience chronic pain, pain services decision making by: ( 1 ) providing an overview relationship between pain; 2 identifying biopsychosocial mechanisms through which may risk persistent 3 highlighting impact on patient adherence completion treatment; 4 practical implications for management. Review findings demonstrated that are associated with increased complications, catastrophizing depression combination these factors further heightens early treatment attrition. The pervasive detrimental impacts COVID-19 pandemic their cyclical effects discussed context decline during long waitlists. highlights how people can be supported by maintaining trauma-informed practices acknowledging outcomes. Clinicians who ACE-informed have potential minimize negative influence outcomes, ultimately optimizing services.

Language: Английский

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The effects of childhood maltreatment on cortical thickness and gray matter volume: a coordinate-based meta-analysis

Psychological Medicine, Journal Year: 2023, Volume and Issue: 53(5), P. 1681 - 1699

Published: March 22, 2023

Abstract Childhood maltreatment has been suggested to have an adverse impact on neurodevelopment, including microstructural brain abnormalities. Existing neuroimaging findings remain inconsistent and heterogeneous. We aim explore the most prominent robust cortical thickness (CTh) gray matter volume (GMV) alterations associated with childhood maltreatment. A systematic search relevant studies was conducted through September 2022. The whole-brain coordinate-based meta-analysis (CBMA) CTh GMV were using seed-based d mapping (SDM) software. Meta-regression analysis subsequently applied investigate potential associations between clinical variables structural changes. total of 45 eligible for inclusion, 11 datasets 39 GMV, consisting 2550 participants exposed 3739 unexposed comparison subjects. Individuals exhibited overlapped deficits in median cingulate/paracingulate gyri simultaneously revealed by both GM studies. Regional thinning right anterior left middle frontal gyrus, as well reductions supplementary motor area (SMA) also identified. No greater regions found either or GMV. In addition, several neural morphology changes average age maltreated individuals. might serve feature effects early-life trauma human predominantly involved cognitive functions, socio-affective functioning stress regulation. This current enhanced understanding neuropathological induced

Language: Английский

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Allostasis, health, and development in Latin America

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 162, P. 105697 - 105697

Published: May 4, 2024

Language: Английский

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Hormonal contraceptive usage influences stress hormone effects on cognition and emotion

Frontiers in Neuroendocrinology, Journal Year: 2022, Volume and Issue: 67, P. 101012 - 101012

Published: July 4, 2022

Language: Английский

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Genome–Environment Interactions and Psychiatric Disorders

Biomedicines, Journal Year: 2023, Volume and Issue: 11(4), P. 1209 - 1209

Published: April 19, 2023

Environmental factors are known to interact with the genome by altering epigenetic mechanisms regulating gene expression and contributing pathogenesis of psychiatric disorders. This article is a narrative review how major environmental contribute common disorders such as schizophrenia, bipolar disorder, depressive anxiety disorder this way. The cited articles were published between 1 January 2000 31 December 2022 obtained from PubMed Google Scholar. search terms used follows: or genetic; genome; environment; mental disorder; epigenetic; interaction. following found act epigenetically on influence disorders: social determinants health, maternal prenatal psychological stress, poverty, migration, urban dwelling, pregnancy birth complications, alcohol substance abuse, microbiota, postnatal infections. also discusses ways which drugs, psychotherapy, electroconvulsive therapy, physical exercise alleviate symptoms in affected patients. These data will be useful information for clinical psychiatrists those researching treatment

Language: Английский

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Blunted diurnal interleukin-6 rhythm is associated with amygdala emotional hyporeactivity and depression: a modulating role of gene-stressor interactions

Frontiers in Psychiatry, Journal Year: 2023, Volume and Issue: 14

Published: May 30, 2023

The immune system has major roles in the brain and related psychopathology. Disrupted interleukin-6 secretion aberrant amygdala emotional reactivity are well-documented stress-related mental disorders. regulates psychosocial affected by genes. These led us to comprehensively examine relationship between interleukin-6, activity, symptoms under gene-stressor interactions.One hundred eight nonclinical participants with various levels of anxiety/depression underwent magnetic resonance imaging scans during an face task for activity saliva collection (at 10-time points across 2 days) total output diurnal patterns interleukin-6. Gene-stressor interactions rs1800796 (C/G) rs2228145 (C/A) stressful life events biobehavioral measures were explored.The blunting pattern was associated hypoactivation basolateral response fearful (vs. neutral) faces (t = 3.67, FWE-corrected p 0.003), predominantly observed individuals C-allele homozygotes negative changes past year (F 19.71, < 0.001). When considered a comprehensive model, diminished predicted greater depressive (β -0.40), modulated hypoactivity 0.36) rs1800796-stressor -0.41; all 0.001).Here we show that blunted rhythm predicts symptoms, hyporeactivity interactions. findings indicate potential mechanism underlying vulnerability disorders, suggesting their early detection, prevention, treatment through understanding dysregulation.

Language: Английский

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Childhood Maltreatment and Amygdala Response to Interpersonal Threat in a Transdiagnostic Adult Sample: The Role of Trait Dissociation

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Journal Year: 2024, Volume and Issue: 9(6), P. 626 - 634

Published: Jan. 26, 2024

Language: Английский

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Factors Associated with the Development of Depression and the Influence of Obesity on Depressive Disorders: A Narrative Review

Biomedicines, Journal Year: 2024, Volume and Issue: 12(9), P. 1994 - 1994

Published: Sept. 2, 2024

Depression affects several aspects of life, including socioeconomic status, relationships, behavior, emotions, and overall health. The etiology depression is complex influenced by various factors, with obesity emerging as a significant contributor. This narrative review aims to investigate the factors associated development depression, particular focus on role obesity. literature search was conducted PubMed, Embase, PsycINFO from May July 2024. highlights impact environmental conditions; lifestyle choices, physical activity dietary habits; stress; traumatic experiences; neurotransmitter imbalances; medical psychological hormone fluctuations; epigenetic depression. A key emphasis placed inflammatory processes linked obesity, which may drive bidirectional relationship between findings suggest that an increased risk potentially due chronic inflammation, neurochemical dysregulation, emotional social challenges related weight stigma management. Understanding these interconnected important for developing targeted interventions address both leading improved quality life those affected.

Language: Английский

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Remembering through the genome: the role of chromatin states in brain functions and diseases

Translational Psychiatry, Journal Year: 2023, Volume and Issue: 13(1)

Published: April 11, 2023

Abstract Chromatin is the physical substrate of genome that carries DNA sequence and ensures its proper functions regulation in cell nucleus. While a lot known about dynamics chromatin during programmed cellular processes such as development, role experience-dependent remains not well defined. Accumulating evidence suggests brain cells, environmental stimuli can trigger long-lasting changes structure tri-dimensional (3D) organization influence future transcriptional programs. This review describes recent findings suggesting plays an important memory, particularly maintenance traces prior activity brain. Inspired by immune epithelial we discuss underlying mechanisms implications for health disease. We conclude presenting holistic view potential molecular integration assimilation information may constitute conceptual basis research.

Language: Английский

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Noradrenergic alterations associated with early life stress

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 164, P. 105832 - 105832

Published: July 29, 2024

Significant stress in childhood or adolescence is linked to both structural and functional changes the brain human analogous animal models. In addition, neuromodulators, such as noradrenaline (NA), show life-long alterations response these early life stressors, which may impact upon sensitivity time course of key adrenergic activities, rapid autonomic responses (the 'fight flight response'). The locus-coeruleus noradrenergic (LC-NA) network, a stress-responsive network brain, displays numerous significant early- stress. Here, we review relationship between NA neurobiological associated with set out future lines research that can illuminate how circuits circulating neurotransmitters adapt stressors.

Language: Английский

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