A nonlinear relationship between alcohol consumption and cognitive function in elderly people: a population-based study from NHANES 2011–2014 DOI Creative Commons
Kaiqi Chen, Yunhua Li, Rui Yue

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Nov. 25, 2024

Objective This study aims to explore the association between alcohol intake and cognitive function in elderly Americans, including potential nonlinear relationships interactions across different subgroups. Methods The analyzed data from National Health Nutrition Examination Survey (NHANES) 2011 2014. sample included 2,675 Americans aged 60 or older. Multivariate regression analysis was used evaluate relationship function. Smooth curve fitting threshold effect were employed relationships. Subgroup analyses conducted examine stability of results Results indicate a significant negative correlation In CERAD total word recall test, for every unit increase intake, score decreased by 0.15 points (−0.15, 95% CI: −0.25, −0.04), delayed it 0.07 (−0.07, −0.12, −0.01). Compared Non-Heavy Drinkers, Heavy Drinkers showed reduction their scores by-0.77 (−0.77, −1.23, −0.32) by-0.28 (−0.28, −0.52, −0.04). revealed function, with breakpoints at 10.7 4.7 Animal fluency 3.85 Digit symbol substitution test. Additionally, subgroup indicated that gender, educational level, smoking status significantly moderated while marital status, race, hypertension, diabetes, cancer no interactions. Conclusion is complex, influenced both amount individual characteristics.

Language: Английский

A narrative review on alcohol use in women: insight into the telescoping hypothesis from a biopsychosocial perspective DOI Creative Commons
Dylan Kirsch, Malia A. Belnap, Annabel Kady

et al.

The American Journal of Drug and Alcohol Abuse, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: Jan. 27, 2025

Background: There has been a dramatic rise in alcohol consumption and use disorder (AUD) among women. Recently, the field made substantial progress toward better understanding sex gender differences AUD. This research suggested accelerated progression to AUD associated health consequences women, phenomenon referred as "telescoping."Objective: To examine evidence for telescoping hypothesis from biopsychosocial perspective.Methods: narrative review examined integrated on biological, psychological, socio-environmental factors that may contribute development of women.Results: Biopsychosocial revealed sex- gender-specific risk pathways onset progression. Biological render females more vulnerable alcohol-related toxicity across various biological systems, including brain. Notably, are consistently observed neural circuitry underlying emotional stress regulation, hypothesized increase an internalizing pathway Psychological indicates women experience greater negative emotionality likely means alleviate emotions compared with men. Socio-environmental factors, such familial peer isolation, appear interact psychological processes way increases women.Conclusion: appears be complex interplay through pathway. Developing targeted interventions specifically target is critical.

Language: Английский

Citations

1
Stress-enhanced ethanol drinking does not increase sensitivity to the effects of a CRF-R1 antagonist on ethanol intake in male and female mice DOI

Michelle A. Nipper,

Melinda L. Helms,

Deborah A. Finn

et al.

Alcohol, Journal Year: 2024, Volume and Issue: 120, P. 73 - 83

Published: Jan. 5, 2024

Language: Английский

Citations

6
Traumatic stress‐enhanced ethanol drinking: Sex, but not stress responsivity, alters sensitivity to the effects of a CRF‐R1 antagonist and a GPR39 agonist in mice DOI Creative Commons

Melinda L. Helms,

Deborah A. Finn,

Michelle A. Nipper

et al.

Alcohol Clinical and Experimental Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Abstract Background Predator stress (PS) is used to model trauma leading post‐traumatic disorder, and it increases ethanol drinking in a proportion of male female rodents. The goals the present studies were identify mice with prior binge experience that exhibited sensitivity resilience PS‐enhanced then test two target molecules (corticotropin releasing factor receptor 1 [CRF‐R1] antagonist NBI‐27914 [NBI] G‐protein coupled 39 [GPR39] agonist TC‐G 1008 [TC‐G]) for their ability selectively reduce drinking. Methods Adult C57BL/6J received seven sessions, period abstinence, acclimation lickometer chambers examine effects NBI or on stress‐associated Following establishment stable baseline (BL) four intermittent PS exposures, classified into “Sensitive” “Resilient” subgroups, based change from BL after PS2‐4. Then, injections vehicle drug (NBI TC‐G) within‐subjects design. Control examined drinking, locomotor activity, saccharin intake. Results significantly suppressed control studies. However, compounds decrease did not differ between animals “PS‐sensitive” versus “PS‐resilient” insensitive traumatic model. Specifically, doses 5 10 mg/kg (males) 12.5 (females) decreased PS‐associated both subgroups. (7.5 mg/kg) subgroups but mice. Conclusions findings suggest subsequent enhanced subgroup may increase CRF‐R1 antagonism GPR39 agonism.

Language: Английский

Citations

0
Neuroendocrine responses and coupling to laboratory-induced stress in problem gambling and heavy smoking DOI
Stephanie Wemm, Cathryn Glanton Holzhauer,

L.J. Harrison

et al.

Psychoneuroendocrinology, Journal Year: 2025, Volume and Issue: unknown, P. 107469 - 107469

Published: April 1, 2025

Language: Английский

Citations

0
Mixing energy drinks and alcohol during adolescence impairs brain function: a study of rat hippocampal plasticity DOI Creative Commons
Francesca Biggio, Giuseppe Talani,

Gino Paolo Asuni

et al.

Neuropharmacology, Journal Year: 2024, Volume and Issue: 254, P. 109993 - 109993

Published: May 11, 2024

In the last decades, consumption of energy drinks has risen dramatically, especially among young people, adolescents and athletes, driven by constant search for ergogenic effects, such as increase in physical cognitive performance. parallel, mixed ethanol, under a binge drinking modality, similarly grown adolescents. However, little is known whether combined these drinks, during adolescence, may have long-term effects on central function, raising question risks this habit brain maturation. Our study was designed to evaluate, behavioral, electrophysiological molecular approaches, hippocampal plasticity ethanol (EtOH), (EDs), or alcohol with (AMED) rat model binge-like adolescent administration. The results show that AMED administration produces adaptive changes at level, associated behavioral alterations, which develop adolescence are still detectable adult animals. Overall, indicates exposure represents affect permanently plasticity.

Language: Английский

Citations

3
Sex differences in the microglial response to stress and chronic alcohol exposure in mice DOI Creative Commons
Alexa R. Soares, Vernon Garcia‐Rivas,

Caroline Fai

et al.

Biology of Sex Differences, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 4, 2025

Women are more susceptible to stress-induced alcohol drinking, and preclinical data suggest that stress can increase intake in female rodents; however, a comprehensive understanding of the neurobiological processes underlying this sex difference is still emerging. Neuroimmune signaling, particularly by microglia, brain's macrophages, known contribute dysregulation limbic circuits following exposure. Females exhibit heightened immune reactivity, so we set out characterize differences microglial response Male C57BL/6J mice were administered over 15 or 22 trials modified Drinking Dark paradigm, with repeated exposure inescapable footshock stress-paired context. Mice perfused immediately after drinking performed immunohistochemical analyses density, morphology, protein expression subregions amygdala hippocampus. We observed dynamic phenotypes at baseline alcohol. Microglia hippocampus displayed prominent reactivity Chronic decreased density microglia lysosomal expression. analyzed multiple measures activation, resulting assessment changes mediated sex, stress, These findings highlight complexity contributions development AUD comorbid mood disorders men women.

Language: Английский

Citations

0
Traumatic Stress-Enhanced Alcohol Drinking: Sex Differences and Animal Model Perspectives DOI

Deborah A. Finn,

Crystal D. Clark, Andrey E. Ryabinin

et al.

Current Addiction Reports, Journal Year: 2024, Volume and Issue: 11(2), P. 327 - 341

Published: Jan. 10, 2024

Language: Английский

Citations

2
Role of microglia in stress-induced alcohol intake in female and male mice DOI Open Access
Alexa R. Soares, Vernon Garcia‐Rivas,

Caroline Fai

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 6, 2024

Abstract Rates of alcohol use disorder (AUD) have escalated in recent years, with a particular increase among women. Women are more susceptible to stress-induced drinking, and preclinical data suggest that stress can intake female rodents; however, comprehensive understanding sex-specific neurobiological substrates underlying this phenomenon is still emerging. Microglia, the resident macrophages brain, essential for reshaping neuronal processes, microglial activity contributes overall plasticity. We investigated dynamics morphology limbic brain structures male mice following exposure stress, or both challenges. In modified paradigm intermittent binge drinking (repeated “drinking dark”), we determined female, but not male, increased their consumption after physical stressor re-exposure trials stress-paired context. Ethanol (EtOH) altered number parameters, including number, subregions amygdala hippocampus, effects were somewhat pronounced mice. used CSF1R antagonist PLX3397 deplete microglia determine whether contribute escalation EtOH intake. observed depletion attenuated no effect unstressed group. These findings under stressful conditions, highlight importance evaluating mechanisms could result tailored interventions AUD

Language: Английский

Citations

1
Alcohol consumption and preference in female rats induced by reward downshift reveals sex generality of the modulatory role of physical activity DOI

Elena Castejón,

Emilio Ambrosio, Ricardo Pellón

et al.

Behavioural Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 25, 2024

Increased voluntary consumption of alcohol has been demonstrated in male rats exposed to frustrative reward downshift (the emotional self-medication effect). Access a wheel for running abolished this effect rats, suggesting an attenuating physical exercise on the negative affect induced by and its consequences drug intake. The present study analyzed female rats. Sixty-four food-deprived Wistar received 32% sucrose [4% (Experiment 1) or 2% 2) controls] during 10, 5-min preshift sessions followed 4% 5 postshift sessions. Immediately after each consummatory session, animals were 2-h, two-bottle preference test involving vs. water. Half also had access test. results showed (a) lower downshifted groups (32-4% 32-2%) compared unshifted controls (4-4% 2-2%, respectively); (b) higher without with (Experiments 1 2); (c) increased intake (g/kg) experiencing 1). Voluntary thus reduced downshift. These findings are comparable previous reported support usefulness prevent nonreward.

Language: Английский

Citations

0
A nonlinear relationship between alcohol consumption and cognitive function in elderly people: a population-based study from NHANES 2011–2014 DOI Creative Commons
Kaiqi Chen, Yunhua Li, Rui Yue

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Nov. 25, 2024

Objective This study aims to explore the association between alcohol intake and cognitive function in elderly Americans, including potential nonlinear relationships interactions across different subgroups. Methods The analyzed data from National Health Nutrition Examination Survey (NHANES) 2011 2014. sample included 2,675 Americans aged 60 or older. Multivariate regression analysis was used evaluate relationship function. Smooth curve fitting threshold effect were employed relationships. Subgroup analyses conducted examine stability of results Results indicate a significant negative correlation In CERAD total word recall test, for every unit increase intake, score decreased by 0.15 points (−0.15, 95% CI: −0.25, −0.04), delayed it 0.07 (−0.07, −0.12, −0.01). Compared Non-Heavy Drinkers, Heavy Drinkers showed reduction their scores by-0.77 (−0.77, −1.23, −0.32) by-0.28 (−0.28, −0.52, −0.04). revealed function, with breakpoints at 10.7 4.7 Animal fluency 3.85 Digit symbol substitution test. Additionally, subgroup indicated that gender, educational level, smoking status significantly moderated while marital status, race, hypertension, diabetes, cancer no interactions. Conclusion is complex, influenced both amount individual characteristics.

Language: Английский

Citations

0