Exposure to nonylphenol in early life causes behavioural deficits related with autism spectrum disorders in rats

Environment International, Journal Year: 2023, Volume and Issue: 180, P. 108228 - 108228

Published: Sept. 27, 2023

Early-life exposure to environmental endocrine disruptors (EDCs) is a potential risk factor for autism spectrum disorder (ASD). Exposure nonylphenol (NP), typical EDC, known cause some long-term behavioural abnormalities. Moreover, these abnormal behaviours are the most frequent psychiatric co-morbidities in ASD. However, direct evidence link between NP early life and ASD-like phenotypes still missing. In present study, induced by valproic acid treatment were considered as positive control. We investigated impacts on social following early-life NP, explored effects of this neuronal dendritic spines, mitochondria function, oxidative stress, endoplasmic reticulum (ER) stress. Furthermore, primary cultured rat neurons employed vitro model evaluate changes spine caused stress ER specifically modulated further explore their roles changes. Our results indicated rats exposed showed mild behaviours. we also found activation triggered may contribute decrease synaptic dysfunction, which underlie neurobehavioural abnormalities NP.

Language: Английский

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Early-Life Exposure to 4-Hydroxy-4′-Isopropoxydiphenylsulfone Induces Behavioral Deficits Associated with Autism Spectrum Disorders in Mice

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(36), P. 15984 - 15996

Published: Aug. 28, 2024

Exposure to bisphenol A (BPA) during gestation and lactation is considered be a potential risk factor for autism spectrum disorder (ASD) in both humans animals. As novel alternative BPA, 4-hydroxy-4′-isopropoxydiphenylsulfone (BPSIP) frequently detected breast milk placental barrier systems, suggesting transmission from the mother offspring increased of exposure. Gestation are critical periods central nervous system development, which vulnerable certain environmental pollutants. Herein, we investigated behavioral impacts neurobiological effects early-life exposure BPSIP (0.02, 0.1, 0.5 mg/kg body weight/day) mice offspring. Behavioral studies indicated that induced ASD-like behaviors, including elevated anxiety-related behavior decreased spatial memory, male female pups. distinct pattern reduced social novelty was observed only offspring, accompanied by significant alterations antioxidant levels. Transcriptome analysis demonstrated differentially expressed genes (DEGs) were mainly enriched pathways related behaviors neurodevelopment, consistent with phenotype. Besides, decrease protein levels complex IV (COX IV) across all tested populations suggests profound impact on mitochondrial function, potentially leading abnormal energy metabolism individuals autism. Additionally, changes synaptic proteins, evidenced synapsin 1 (SYN1) postsynaptic density protein-95 (PSD95) cerebellum hippocampus, support notion involvement. These findings suggest may induce sex-specific neurotoxic involve oxidative stress, generation, plasticity.

Language: Английский

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Autism Spectrum Disorders

Primary Care Clinics in Office Practice, Journal Year: 2021, Volume and Issue: 48(3), P. 461 - 473

Published: July 8, 2021

Language: Английский

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Autism-Related Transcription Factors Underlying the Sex-Specific Effects of Prenatal Bisphenol A Exposure on Transcriptome-Interactome Profiles in the Offspring Prefrontal Cortex

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(24), P. 13201 - 13201

Published: Dec. 8, 2021

Bisphenol A (BPA) is an environmental risk factor for autism spectrum disorder (ASD). BPA exposure dysregulates ASD-related genes in the hippocampus and neurological functions of offspring. However, whether prenatal has impact on prefrontal cortex, another brain region highly implicated ASD, through what mechanisms have not been investigated. Here, we demonstrated that disrupts transcriptome–interactome profiles cortex neonatal rats. Interestingly, list BPA-responsive was significantly enriched with known ASD candidate genes, as well were dysregulated postmortem tissues cases from multiple independent studies. Moreover, several differentially expressed offspring’s targets transcription factors, including AR, ESR1, RORA. The hypergeometric distribution analysis revealed may regulate expression such these factors a sex-dependent manner. molecular docking novel potential BPA, RORA, SOX5, TCF4, YY1. Our findings indicated increase mechanisms, which should be investigated further.

Language: Английский

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Sex-specific Effects of Endocrine-disrupting Chemicals on Brain Monoamines and Cognitive Behavior

Endocrinology, Journal Year: 2022, Volume and Issue: 163(10)

Published: Aug. 8, 2022

Abstract The period of brain sexual differentiation is characterized by the development hormone-sensitive neural circuits that govern subsequent presentation sexually dimorphic behavior in adulthood. Perturbations hormones endocrine-disrupting chemicals (EDCs) during this developmental interfere with an organism’s endocrine function and can disrupt normative organization male- or female-typical circuitry. This well for reproductive social behaviors their underlying circuitry hypothalamus other limbic regions brain; however, cognitive are also dimorphic, potentially vulnerable to EDC exposure critical periods development. review provides recent evidence sex-specific changes brain’s monoaminergic systems (dopamine, serotonin, norepinephrine) after relates these outcomes sex differences cognition such as affective, attentional, learning/memory behaviors.

Language: Английский

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