Rapid nongenomic estrogen signaling controls alcohol drinking behavior DOI Creative Commons
Lia J. Zallar,

Jean K. Rivera-Irizarry,

Peter U. Hámor

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 5, 2023

Abstract Ovarian-derived estrogen is a key modulator of numerous physiological processes via genomic and nongenomic mechanisms, including signaling non-canonically at membrane-associated receptors in the brain to rapidly regulate neuronal function. However, mechanisms mediating regulation behaviors such as alcohol consumption remain unclear. Early drinking confers greater risk for use disorder women than men, binge correlated with high circulating levels, but causal role driving gonadally-intact animals has not been established. We found that female mice displayed reduced avoidance behavior when was during proestrus phase estrous cycle it low, contributing sex differences these behaviors. The pro-drinking, anxiolytic, effect endogenous state occurred rapid receptor alpha bed nucleus stria terminalis, which promoted synaptic excitation corticotropin-releasing factor neurons facilitated their activity behavior. This study first demonstrate rapid, mechanism ovarian-derived controlling gonadally intact females, establishes an hormonal context contributes known this

Language: Английский

The impact of estrous cycle on anxiety-like behaviour during unlearned fear tests in female rats and mice: A systematic review and meta-analysis DOI Creative Commons
Jodie E. Pestana, Bronwyn M. Graham

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 164, P. 105789 - 105789

Published: July 14, 2024

Anxiety fluctuates across the human menstrual cycle, with symptoms worsening during phases of declining or low ovarian hormones. Similar findings have been observed rodent estrous however, magnitude and robustness these effects not meta-analytically quantified. We conducted a systematic review meta-analysis cycle on anxiety-like behaviour (124 articles; k = 259 effect sizes). In both rats mice, was higher metestrus/diestrus (lower hormones) than proestrus (higher (g 0.44 in rats, g 0.43 mice). There large heterogeneity data, which partially accounted for by strain, experimental task, reproductive status. Nonetheless, highly robust, fail-safe N test revealing would remain significant even if 21,388 additional studies yielded null results. These results suggest that should be anxiety females. Doing so will facilitate knowledge about menstrual-cycle regulation disorders humans.

Language: Английский

Citations

10
Dietary phytoestrogens recalibrate socioemotional behavior in C57Bl/6J mice in a sex- and timing-dependent manner DOI
Carel W. le Roux, Amy Farthing, Elizabeth K. Lucas

et al.

Hormones and Behavior, Journal Year: 2025, Volume and Issue: 168, P. 105678 - 105678

Published: Jan. 17, 2025

Language: Английский

Citations

0
Rapid nongenomic estrogen signaling controls alcohol drinking behavior in mice DOI Creative Commons
Lia J. Zallar, Jean K. Rivera-Irizarry, Peter U. Hámor

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 30, 2024

Abstract Ovarian-derived estrogen can signal non-canonically at membrane-associated receptors in the brain to rapidly regulate neuronal function. Early alcohol drinking confers greater risk for use disorder women than men, and binge is correlated with high levels, but a causal role driving has not been established. We found that female mice displayed reduced avoidance when was during estrous cycle it low. The pro-drinking, anxiolytic, effect of endogenous occurred via rapid signaling receptor alpha bed nucleus stria terminalis, which promoted synaptic excitation corticotropin-releasing factor neurons facilitated their activity drinking. Thus, this study demonstrates rapid, nongenomic mechanism ovarian-derived controlling behavior gonadally intact females.

Language: Английский

Citations

3
Sex-based differences in the prevention of stress-induced anxiety by Resolvin D5 and its precursor docosahexaenoic acid: A comparative study DOI
J.J. Fedriani de Matos, Alvaro Henrique Bernardo de Lima Silva, Matheus Vinícius Ferreira

et al.

Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 149612 - 149612

Published: March 1, 2025

Language: Английский

Citations

0
Effects of repetition and estrous cycle on behavioral tests in female ICR mice DOI
Michiyo Maruyama

Neuroscience Letters, Journal Year: 2025, Volume and Issue: unknown, P. 138253 - 138253

Published: May 1, 2025

Language: Английский

Citations

0
Rapid nongenomic estrogen signaling controls alcohol drinking behavior DOI Creative Commons
Lia J. Zallar,

Jean K. Rivera-Irizarry,

Peter U. Hámor

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 5, 2023

Abstract Ovarian-derived estrogen is a key modulator of numerous physiological processes via genomic and nongenomic mechanisms, including signaling non-canonically at membrane-associated receptors in the brain to rapidly regulate neuronal function. However, mechanisms mediating regulation behaviors such as alcohol consumption remain unclear. Early drinking confers greater risk for use disorder women than men, binge correlated with high circulating levels, but causal role driving gonadally-intact animals has not been established. We found that female mice displayed reduced avoidance behavior when was during proestrus phase estrous cycle it low, contributing sex differences these behaviors. The pro-drinking, anxiolytic, effect endogenous state occurred rapid receptor alpha bed nucleus stria terminalis, which promoted synaptic excitation corticotropin-releasing factor neurons facilitated their activity behavior. This study first demonstrate rapid, mechanism ovarian-derived controlling gonadally intact females, establishes an hormonal context contributes known this

Language: Английский

Citations

2