Revisiting the specific and potentially independent role of the gonad in hormone regulation and reproductive behavior DOI
Victoria S. Farrar

Journal of Experimental Biology, Journal Year: 2024, Volume and Issue: 227(21)

Published: Nov. 1, 2024

ABSTRACT Gonadal sex steroid hormones are well-studied modulators of reproductive physiology and behavior. Recent behavioral endocrinology research has focused on how the brain dynamically responds to – may even produce steroids, but gonadal tissues that primarily release these receive much less attention as a potential mediator variation. This Commentary revisits mechanisms by which hypothalamic–pituitary–gonadal (HPG) axis can be modulated specifically at level. These include those allow gonad regulated independently HPG axis, such receptors for non-HPG hormones, neural inputs local production conventional ‘neuropeptides'. Here, I highlight studies examine variation in diverse taxa, with an emphasis recent transcriptomic work. then outline future work establish functional roles behavior evaluate responsiveness environmental cues. When integrated mechanisms, further investigation hormone regulation yield new insight into control evolution steroid-mediated traits, including

Language: Английский

Sex contextualism in laboratory research: Enhancing rigor and precision in the study of sex-related variables DOI Creative Commons
Madeleine Pape, Miriam Miyagi, Stacey A. Ritz

et al.

Cell, Journal Year: 2024, Volume and Issue: 187(6), P. 1316 - 1326

Published: March 1, 2024

Language: Английский

Citations

26
Rigorous science demands support of transgender scientists DOI Creative Commons
Krisha Aghi, Brendan M. Anderson,

Bria M. Castellano

et al.

Cell, Journal Year: 2024, Volume and Issue: 187(6), P. 1327 - 1334

Published: March 1, 2024

Language: Английский

Citations

11
Sex differences in the rodent medial prefrontal cortex – What Do and Don't we know? DOI
Mikaela A. Laine, Eliza M. Greiner, Rebecca M. Shansky

et al.

Neuropharmacology, Journal Year: 2024, Volume and Issue: 248, P. 109867 - 109867

Published: Feb. 20, 2024

Language: Английский

Citations

6
Incorporating Sex-Diverse and Gender-Inclusive Perspectives in Higher Education Biology Courses DOI
Breanna N. Harris, Adam Lewis, Sam L. Sharpe

et al.

Integrative and Comparative Biology, Journal Year: 2024, Volume and Issue: unknown

Published: June 3, 2024

Inclusive teaching is in a way that reaches all students the classroom; this beneficial for everyone and particularly those with minoritized identities. Instructors play critical role scaffolding how are exposed to learn science content classroom. In manuscript we discuss biology instructors can make their classrooms more inclusive regard sex gender diversity content. Many topics based on androcentric, heteronormative, oppressive framing, even though lenses reflective of our own history culture than they see nature. Here, summarize information presented SICB 2024 workshop titled "Incorporating inclusivity undergraduate classrooms" provide a) rationale why matters, b) guidance challenge unscientific views curricula sex-diverse inclusive, c) practical easy-to-implement strategies discussing "contentious" Incorporation material will be students, medicine, accurately representing found across tree life.

Language: Английский

Citations

4
Depression in adolescence and young adulthood: the difficulty to integrate motivational/emotional systems DOI Creative Commons

Teodosio Giacolini,

Antonio Alcaro,

David Conversi

et al.

Frontiers in Psychology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 6, 2025

Depression is presented as a multi-factorial bio-psycho-social expression that has evolved primarily an effect of stressors related to the motivational/emotional systems regulate BrainMind in our relationship with conspecifics. These may be caused by two sources threat, firstly, loss bonding caregiver and later partner and/or group which relates SEPARATION (PANIC/GRIEF) system, secondly, social defeat competition dominance. The sexual maturity drives individual dominance, even if latter often occurs before maturity, e.g., chickens, dogs, non-human primates, humans. evolutionarily conserved mechanism mammals terminate both separation anxiety, so protect vulnerable brain from consequences prolonged stress when predictable. Adolescence Young adulthood are particularly susceptible these types threat because human developmental characteristics summarized term neoteny. This refers slowing down growth development, resulting period dependence on caring/protective adult persistence juvenile throughout life. Therefore, neoteny makes transition childhood more dramatic, making integration system dynamics dominance stressful source depression. Stress HPA-Hypothalamic-Pituitary-Adrenal axis articulates other systems, mainly autonomic nervous immune-inflammatory system. believed one most significant components depressive processes, connected prodromes its activation childhood, under pressure environmental relational can lead learned helplessness. recurrence it easier for activated life, could make contribution establishment disease. possible children's identification processes their parents' personalities through observational learning considered.

Language: Английский

Citations

0
A Review of Sex and Gender Factors in Stimulant Treatment for ADHD: Knowledge Gaps and Future Directions DOI Creative Commons
Iris L. Rapoport, Annabeth P. Groenman

Journal of Attention Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Objective: Stimulant medications are the primary pharmacological intervention for ADHD, yet our understanding of how sex and gender impact stimulant treatment outcomes remains limited. Clinical guidelines do not differ female male individuals despite possible gender-related differences in effectiveness, adverse events, pharmacokinetics. This theoretical framework identifies five key knowledge gaps relating to effects treatment. Method: We investigate trajectories girls women with ADHD from diagnosis prescription daily use outcomes. examine reproductive life transitions hormonal fluctuations their interactions socialization gendered expectations on stigma, adherence. Results: By synthesizing existing literature, proposing testable predictions, suggesting future research directions, we highlight urgent need studies that systematically these factors. Conclusion: Addressing could significantly improve particularly during biological role transitions.

Language: Английский

Citations

0
What birds can teach us about the ‘biological truth’ of sex DOI
Nicole M. Baran

The Transmitter, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Effects of arginine vasopressin on human anxiety and associations with sex, dose, and V1a-receptor genotype DOI
Richmond R. Thompson,

D. E. Price,

David Burris

et al.

Psychopharmacology, Journal Year: 2024, Volume and Issue: 241(6), P. 1177 - 1190

Published: Feb. 15, 2024

Language: Английский

Citations

3
Estrogenic influences on agonistic behavior in teleost fishes DOI
Katherine A. Stennette, John Godwin

Hormones and Behavior, Journal Year: 2024, Volume and Issue: 161, P. 105519 - 105519

Published: March 6, 2024

Language: Английский

Citations

3
Training in the implementation of sex and gender research policies: an evaluation of publicly available online courses DOI Creative Commons
Annika Gompers,

Madeline T. Olivier,

Donna L. Maney

et al.

Biology of Sex Differences, Journal Year: 2024, Volume and Issue: 15(1)

Published: April 3, 2024

Recently implemented research policies requiring the inclusion of females and males have created an urgent need for effective training in how to account sex, some cases gender, biomedical studies. Here, we evaluated three sets publicly available online materials on this topic: (1) Integrating Sex & Gender Health Research from Canadian Institutes (CIHR); (2) as a Biological Variable: A Primer United States National (NIH); (3) The Dimension Biomedical Research, developed part "Leading Innovative measures reach gender Balance Activities" (LIBRA) European Commission. We reviewed each course with respect their coverage What is required by policy; Rationale Handling concepts "sex" "gender;" (4) design analysis; (5) Interpreting reporting data. All courses discussed importance including better generalize results, discover potential sex differences, tailor treatments men women. entangled nature operationalization downsides focusing more than other sources variation were minimally discussed. Notably, all explicitly endorsed invalid analytical approaches that produce bias toward false positive discoveries difference. Our analysis suggests revised or new incorporate four major topics: precise risks over-emphasis category, recognition complex entangled, rigorous study data analysis.

Language: Английский

Citations

3