Relationship Between Sleep Time and Depressive Symptoms in Middle-Aged and Elderly Chinese: Mediating Role of Body Pain

Psychology Research and Behavior Management, Journal Year: 2025, Volume and Issue: Volume 18, P. 67 - 79

Published: Jan. 1, 2025

Objective: Existing research has yet to adequately examine the correlation between sleep time, body pain, and depressive symptoms. This study seeks elucidate interconnections these three elements. Methods: The used 2020 CHARLS data for analysis. To assess intricate association among symptoms, employed Spearman analysis, multiple logistic regression, restricted cubic splines, mediation effect analysis based on bootstrap testing. Results: Risk factors symptoms in middle-aged elderly Chinese include physical pain reduced duration. Results from RCS suggest that lowest risk of occurs when time population is approximately 7.5 hours. Body accounts a 19.05% mediating even after controlling confounding factors, there remains 7.5% effect. Conclusion: findings indicate significant Insufficient can lead plays partial role Keywords: people,

Language: Английский

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The dual-hormone hypothesis and first-time fathers’ relationship satisfaction at 3 months postpartum

Frontiers in Psychology, Journal Year: 2025, Volume and Issue: 16

Published: May 22, 2025

Human males face tradeoffs in how they invest resources toward mating and parenting. Research on male’s transition to fatherhood has revealed shifts hormones tied these tradeoffs. While work focused the influence of parenting during this stage, less is known about (i.e., relationship functioning with partner) postnatal period. A father’s satisfaction expected be related endocrine activity across parenthood. We predicted that first-time fathers high testosterone (T) would report lower satisfaction. effect amplified (moderation) for those cortisol (CORT) levels dual hormone hypothesis). At 3 months postpartum we measured salivary T CORT ( n = 220) recorded using Investment Model Scale (IMS). found low had highest was small, findings ran counter our predictions. speculate higher may increased as support, retain, secure additional opportunities from a mate who recently demonstrated her ability (and willingness) produce offspring. Discussion focuses numerous limitations study, small size, need replication homogenous samples.

Language: Английский

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Correlation between the neuroendocrine axis, microbial species, inflammatory response, and gastrointestinal symptoms in irritable bowel syndrome

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(35), P. 3985 - 3995

Published: Sept. 12, 2024

This study examines the complex relationships among neuroendocrine axis, gut microbiome, inflammatory responses, and gastrointestinal symptoms in patients with irritable bowel syndrome (IBS). The findings provide new insights into pathophysiology of IBS suggest potential therapeutic targets for improving patient outcomes.

Language: Английский

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Patient-reported outcomes of rezvilutamide versus bicalutamide in combination with androgen deprivation therapy in high-volume metastatic hormone-sensitive prostate cancer patients (CHART): a randomized, phase 3 study

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Dec. 17, 2024

Abstract The randomized phase 3 CHART trial (NCT03520478) revealed that rezvilutamide (REZ) plus androgen deprivation therapy (ADT) in high-volume, metastatic, hormone-sensitive prostate cancer (mHSPC) significantly enhanced radiographic progression-free and overall survival than bicalutamide (BIC)-ADT. Accordingly, we examined patient-reported outcomes (PROs) results, which were exploratory endpoints the trial. patients randomly allocated to receive REZ-ADT or BIC-ADT a 1:1 ratio. PROs evaluated with Brief Pain Inventory-Short Form (BPI-SF) Functional Assessment of Cancer Therapy-Prostate (FACT-P) questionnaires. Both study groups displayed comparable baseline pain scores functional status. Patients administered had an extended time progression worst intensity comparison those treated (25th percentile, 9.2 [95% CI 7.4–16.6] vs. 6.4 months 5.5–8.3]; HR 0.75 0.57–0.97]; p = 0.026). Similarly, received exhibited delayed interference receiving 20.2 12.9–31.3] 10.2 7.4–11.1]; 0.70 0.52–0.93]; 0.015). Additionally, group demonstrated prolonged delay deterioration total score on FACT-P questionnaire 12.8 7.4–20.3] 6.0 4.6–9.2]; 0.66 0.50–0.86]; 0.002), as well most subscale scores, group. In conclusion, is superior regarding alleviation enhancement scales for high-volume mHSPC.

Language: Английский

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Understanding stress‐induced transmission of peripherally derived factors into the brain and responses in non‐neuronal cells

Journal of Neurochemistry, Journal Year: 2024, Volume and Issue: 169(1)

Published: Dec. 22, 2024

Abstract Stress is a significant cause of mental disorders, for which effective treatments remain limited due to an insufficient understanding its pathogenic mechanisms. Recent research has increasingly focused on non‐neuronal cells elucidate the molecular mechanisms underlying psychopathology. In this review, we summarize current knowledge how in central nervous system, including microglia, astrocytes, and oligodendrocytes, respond peripherally derived stress‐related factors these responses contribute development disorders. A more comprehensive stress‐induced alterations, with careful consideration type timing stress exposure, will provide fundamental insights into pathogenesis diverse image

Language: Английский

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