Adolescent alcohol consumption produces long term changes in response inhibition and orbitofrontal-striatal activity in a sex-specific manner
Developmental Cognitive Neuroscience,
Journal Year:
2025,
Volume and Issue:
73, P. 101552 - 101552
Published: March 19, 2025
Language: Английский
Oral Fentanyl Consumption Alters Sleep Rhythms, Promotes Avoidance Behaviors, Impairs Fear Extinction Learning, and Alters Basolateral Amygdala Physiology in Male and Female Mice
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Nov. 29, 2023
Abstract
The
number
of
opioid
overdose
deaths
has
increased
over
the
past
several
years,
mainly
driven
by
an
increase
in
availability
highly
potent
synthetic
opioids,
like
fentanyl,
un-regulated
drug
supply.
Over
last
few
changes
supply,
and
particular
counterfeit
pills
containing
have
made
oral
use
opioids
a
more
common
route
administration.
Here,
we
used
drinking
dark
(DiD)
paradigm
to
model
fentanyl
self-administration
using
increasing
concentrations
male
female
mice
5
weeks.
Fentanyl
consumption
peaked
both
at
30
µg/mL
dose,
with
consuming
significantly
than
mice.
Mice
consumed
sufficient
such
that
withdrawal
was
precipitated
naloxone,
males
having
symptoms,
despite
lower
pharmacological
exposure.
We
also
performed
behavioral
assays
measure
avoidance
behavior
reward-seeking
during
abstinence.
Female
displayed
reduced
behaviors
open
field
assay,
whereas
showed
light/dark
box
assay.
exhibited
sucrose
preference
test.
Fentanyl-consuming
sexes
impaired
cued
fear
extinction
learning
following
conditioning
excitatory
synaptic
drive
excitability
BLA
principal
neurons.
Our
experiments
demonstrate
long-term
results
wide-ranging
physiological
disruptions.
This
could
be
useful
further
study
syndrome
neuroplasticity
associated
protracted
withdrawal.
Language: Английский
Sex Differences in Morphine Sensitivity of Neuroligin-3 Knockout Mice
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 1, 2024
Sex
has
a
strong
influence
on
the
prevalence
and
course
of
brain
conditions,
including
autism
spectrum
disorders.
The
mechanistic
basis
for
these
sex
differences
remains
poorly
understood,
due
in
part
to
historical
bias
biomedical
research
favoring
analysis
male
subjects,
exclusion
female
subjects.
For
example,
studies
mice
carrying
autism-associated
mutations
neuroligin-3
are
over-represented
literature,
our
own
prior
work
showing
diminished
responses
chronic
morphine
exposure
knockout
mice.
We
therefore
studied
how
constitutive
conditional
genetic
affects
sensitivity
In
contrast
mice,
showed
normal
psychomotor
sensitization
after
exposure.
However,
absence
expression,
both
show
similar
change
topography
locomotor
stimulation
produced
by
morphine.
Conditional
deletion
from
dopamine
neurons
increased
response
high
doses
morphine,
contrasting
with
decrease
caused
same
manipulation
Together,
data
reveal
that
common
distinct
effects
These
results
also
support
notion
can
confer
resilience
against
impact
gene
variants.
Language: Английский
Accounting for a mosaic of sex differences: Q&A with Nicola Grissom
Olivia Gieger
No information about this author
The Transmitter,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Language: Английский
Sex differences in morphine sensitivity of neuroligin-3 knockout mice
Psychopharmacology,
Journal Year:
2024,
Volume and Issue:
241(12), P. 2431 - 2440
Published: July 31, 2024
Language: Английский
Oral Fentanyl Consumption and Withdrawal Impairs Fear Extinction Learning and Enhances Basolateral Amygdala Principal Neuron Excitatory-Inhibitory Balance in Male and Female Mice
Addiction Neuroscience,
Journal Year:
2024,
Volume and Issue:
13, P. 100182 - 100182
Published: Oct. 15, 2024
Language: Английский
Interactions of sex and stress in modulation of ventral tegmental area dopaminergic activity
Karen M. Price,
No information about this author
Abigail M. Polter
No information about this author
Current Opinion in Behavioral Sciences,
Journal Year:
2024,
Volume and Issue:
61, P. 101477 - 101477
Published: Dec. 19, 2024
Language: Английский
Adolescent alcohol consumption produces long term alterations in response inhibition and orbitofrontal-striatal activity in a sex-specific manner
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 17, 2024
Abstract
Alcohol
use
disorder
(AUD)
is
strongly
associated
with
initiation
of
drinking
during
adolescence.
Little
known
about
neural
mechanisms
that
produce
the
long-term
detrimental
effects
adolescent
drinking.
A
critical
feature
AUD
deficits
in
response
inhibition,
or
ability
to
withhold
a
reward-seeking
response.
Here
we
sought
determine
if
affects
inhibition
and
encoding
events
by
orbitofrontal
cortex
(OFC)
dorsomedial
striatum
(DMS),
two
regions
for
expression
inhibition.
Adolescent
male
female
rats
were
given
access
alcohol
four
hours
day
five
consecutive
days.
Then,
tested
cued
task
as
adolescents
adults
while
recorded
concomitantly
from
OFC
DMS.
voluntary
impaired
increased
adult
but
not
rats.
also
resulted
sex-specific
on
both
unit
firing
local
field
potential
measures
DMS
premature
correct
actions.
Collectively,
these
data
suggest
corresponding
alterations
cortical-striatal
circuitry.
Highlights
Moderate
disrupts
Action
changes
after
OFC-DMS
connectivity
altered
males
promotes
intake
Language: Английский