Pathways to precision medicine: deciphering the secrets of physiological and pathological atrial enlargement DOI
Shuai Zhao, Xander H.T. Wehrens

Clinical Science, Journal Year: 2024, Volume and Issue: 138(18), P. 1173 - 1177

Published: Sept. 1, 2024

Abstract Cardiac functional, morphological, and histological analysis, coupled with liquid chromatography mass spectrometry, of two transgenic mouse models cardiomyocyte-specific overexpression insulin-like growth factor 1 receptor (IGF1R) or a dominant-negative PI3K mutant (DCM-dnPI3K) revealed distinctive functional molecular profiles during physiological (driven by IGF1R overexpression) pathological dn-PI3K atrial remodeling. The current study confirmed previously reported findings, including ventricular dilatation enhanced systolic function no evidence arrhythmia in model, as well hypertrophy decreased intermittent fibrillation DCM-dnPI3K model. Novel findings obtained from the left (LA) characterization female mice that enlargement resulted increased myocyte size was associated preserved function, determined maintained LA ejection fraction (EF). proteomic profile (Tg) enriched for metabolic remodeling showed protein expression pattern similar to healthy human atria; on other hand, fibrosis normal impaired due reduced EF. both structural AF atria

Language: Английский

Aging-associated mechanisms of atrial fibrillation progression and their therapeutic potential DOI Open Access
Shuai Zhao, Aaron M. Johnston, Chi Him Kendrick Yiu

et al.

The Journal of Cardiovascular Aging, Journal Year: 2024, Volume and Issue: 4(3)

Published: Nov. 7, 2024

Atrial fibrillation (AF) is the most common sustained arrhythmia, with a particularly high prevalence in elderly. As global aging population rapidly expands, it increasingly important to examine how alterations heart contribute an increased AF susceptibility. This work critically reviews key molecular mechanisms that may underpin complex association between and AF. Moreover, we identify emerging novel opportunities for therapeutic intervention be able prevent and/or improve current treatment paradigms age-related review contributes holistic understanding of intricate relationship

Language: Английский

Citations

1
Pathways to precision medicine: deciphering the secrets of physiological and pathological atrial enlargement DOI
Shuai Zhao, Xander H.T. Wehrens

Clinical Science, Journal Year: 2024, Volume and Issue: 138(18), P. 1173 - 1177

Published: Sept. 1, 2024

Abstract Cardiac functional, morphological, and histological analysis, coupled with liquid chromatography mass spectrometry, of two transgenic mouse models cardiomyocyte-specific overexpression insulin-like growth factor 1 receptor (IGF1R) or a dominant-negative PI3K mutant (DCM-dnPI3K) revealed distinctive functional molecular profiles during physiological (driven by IGF1R overexpression) pathological dn-PI3K atrial remodeling. The current study confirmed previously reported findings, including ventricular dilatation enhanced systolic function no evidence arrhythmia in model, as well hypertrophy decreased intermittent fibrillation DCM-dnPI3K model. Novel findings obtained from the left (LA) characterization female mice that enlargement resulted increased myocyte size was associated preserved function, determined maintained LA ejection fraction (EF). proteomic profile (Tg) enriched for metabolic remodeling showed protein expression pattern similar to healthy human atria; on other hand, fibrosis normal impaired due reduced EF. both structural AF atria

Language: Английский

Citations

0