Biophysical and Biochemical Roles of Shear Stress on Endothelium: A Revisit and New Insights DOI
Chak Kwong Cheng, Nanping Wang, Li Wang

et al.

Circulation Research, Journal Year: 2025, Volume and Issue: 136(7), P. 752 - 772

Published: March 27, 2025

Hemodynamic shear stress, the frictional force exerted by blood flow on endothelium, mediates vascular homeostasis. This review examines biophysical nature and biochemical effects of stress endothelial cells, with a particular focus its impact cardiovascular pathophysiology. Atherosclerosis develops preferentially at arterial branches curvatures, where disturbed patterns are most prevalent. The also highlights range across diverse human arteries temporal variations, including aging-related alterations. presents summary critical mechanosensors flow-sensitive effectors that respond to along downstream cellular events they regulate. evaluates experimental models for studying in vitro vivo, as well their potential limitations. discusses strategies targeting pharmacological approaches, physiological means, surgical interventions, gene therapies. Furthermore, addresses emerging perspectives hemodynamic research, single-cell sequencing, spatial omics, metabolomics, multiomics technologies. By integrating aspects this offers insights into complex interplay between hemodynamics homeostasis preclinical clinical levels.

Language: Английский

Biophysical and Biochemical Roles of Shear Stress on Endothelium: A Revisit and New Insights DOI
Chak Kwong Cheng, Nanping Wang, Li Wang

et al.

Circulation Research, Journal Year: 2025, Volume and Issue: 136(7), P. 752 - 772

Published: March 27, 2025

Hemodynamic shear stress, the frictional force exerted by blood flow on endothelium, mediates vascular homeostasis. This review examines biophysical nature and biochemical effects of stress endothelial cells, with a particular focus its impact cardiovascular pathophysiology. Atherosclerosis develops preferentially at arterial branches curvatures, where disturbed patterns are most prevalent. The also highlights range across diverse human arteries temporal variations, including aging-related alterations. presents summary critical mechanosensors flow-sensitive effectors that respond to along downstream cellular events they regulate. evaluates experimental models for studying in vitro vivo, as well their potential limitations. discusses strategies targeting pharmacological approaches, physiological means, surgical interventions, gene therapies. Furthermore, addresses emerging perspectives hemodynamic research, single-cell sequencing, spatial omics, metabolomics, multiomics technologies. By integrating aspects this offers insights into complex interplay between hemodynamics homeostasis preclinical clinical levels.

Language: Английский

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