Salidroside: An Overview of Its Promising Potential and Diverse Applications DOI Creative Commons
Keke Liang, Shuhe Ma, Kai Luo

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(12), P. 1703 - 1703

Published: Dec. 17, 2024

Salidroside, a phenolic compound isolated from various Rhodiola plants, is the principal active constituent of Traditional Chinese Medicine known for its adaptogenic properties. Due to challenging environment species, such as high altitude, radiation, drought, and hypoxia, source salidroside scarce. However, numerous studies have shown that has range biological activities, including cardiovascular central nervous system activity, anti-hypoxia, anti-inflammatory, anti-aging activities. Although previous partially summarized pharmacological effects salidroside, overall not been analyzed. Hence, this review will systematically summarize isolation, purification, synthesis, derivatization, pharmacokinetics, clinical application, safety salidroside. It expected provide new insights further research pharmaceutical development

Language: Английский

Glycosyltransferases: Pioneering Roles in Agriculture and Medicine DOI
Qian Liu, Fengkai Yang,

Yanan Zhang

et al.

Plant Science, Journal Year: 2025, Volume and Issue: unknown, P. 112520 - 112520

Published: April 1, 2025

Language: Английский

Citations

0
Characterization of UDP-glucose pyrophosphorylases from different organisms DOI Open Access
Siqi Zhang,

Xin Song,

Yuqi Qin

et al.

Bioscience Reports, Journal Year: 2025, Volume and Issue: 45(04), P. 263 - 276

Published: April 1, 2025

UDP-glucose pyrophosphorylases (UGPases) catalyze the conversion of UTP and glucose-1-phosphate (Glc1P) to pyrophosphate, playing crucial roles in cell metabolism. The UGPases are related biosynthesis glycans various organisms linked bacterial survival, plant programmed death, even human cancers. Eleven from bacterium Escherichia coli; fungi Saccharomyces cerevisiae (ScUGP) Aspergillus niger (AnUGP); plants Hordeum vulgare (barley) (HvUGP), Arabidopsis thaliana (AtUGP), Solanum tuberosum (potato) (StUGP), Manihot esculenta (cassava) (MeUGP), Ipomoea batatas (sweet potato) (IbUGP), Zea mays (maize) (ZmUGP); animals Drosophila melanogaster (fruit fly) (DmUGP) Homo sapiens (human) (HsUGP) were expressed E. coli assayed. MeUGP StUGP have highest second-highest specific activities, respectively. second-order rate constant kcat/Km values 11 ranked high low following order: > ZmUGP IbUGP AtUGP AnUGP HvUGP HsUGP DmUGP ScUGP EcUGP. EcUGP, ScUGP, AnUGP, HvUGP, AtUGP, DmUGP, show a temperature optimum 37℃. MeUGP, IbUGP, showed 50℃. Overall, recombinant not thermally stable. Ten rapidly inactivated at 60℃ except for IbUGP. use Glc1P with activities. exhibit variations nucleoside triphosphate (NTP) utilization efficiency. results improve knowledge characteristics UGPase provide potential or as engineering target factories.

Language: Английский

Citations

0
Advances and Challenges in Biomanufacturing of Glycosylation of Natural Products DOI Creative Commons

Shunyang Hu,

Bangxu Wang,

Liang Pei

et al.

Fermentation, Journal Year: 2024, Volume and Issue: 10(7), P. 349 - 349

Published: July 9, 2024

Glycosylation is one of the most common and important modifications in natural products (NPs), which can alter biological activities properties NPs, effectively increase structural diversity, improve pharmacological activities. The biosynthesis glycosylation involves multiple complex processes, are coordinated by many enzymes. UDP-glycosyltransferases (UGTs) play a crucial role modification, have attracted long-term widespread research attention. UGTs catalyze O-, C-, S-, N-glycosylation different substrates, producing variety glycosides with broad activity, while improving solubility, stability, bioavailability, other functions NPs. In recent years, rapid development synthetic biology advanced manufacturing technologies, especially application artificial intelligence field biology, has led to series new discoveries NP UGT. This work summarizes latest progress challenges glycosylation, covering results potential applications glycosylated derivatives terpenes, flavonoids, polyphenols, aromatic compounds, compounds terms biogenesis. Looking future, may leverage intelligence-driven techniques decipher genes related pathway, expected further promote large-scale synthesis diversity NPs pharmaceutical, functional food, cosmetic industries.

Language: Английский

Citations

3
Salidroside: An Overview of Its Promising Potential and Diverse Applications DOI Creative Commons
Keke Liang, Shuhe Ma, Kai Luo

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(12), P. 1703 - 1703

Published: Dec. 17, 2024

Salidroside, a phenolic compound isolated from various Rhodiola plants, is the principal active constituent of Traditional Chinese Medicine known for its adaptogenic properties. Due to challenging environment species, such as high altitude, radiation, drought, and hypoxia, source salidroside scarce. However, numerous studies have shown that has range biological activities, including cardiovascular central nervous system activity, anti-hypoxia, anti-inflammatory, anti-aging activities. Although previous partially summarized pharmacological effects salidroside, overall not been analyzed. Hence, this review will systematically summarize isolation, purification, synthesis, derivatization, pharmacokinetics, clinical application, safety salidroside. It expected provide new insights further research pharmaceutical development

Language: Английский

Citations

2