C17orf80 binds the mitochondrial genome to promote its replication DOI
Hao Wu, Wenshuo Zhang, Fengli Xu

et al.

The Journal of Cell Biology, Journal Year: 2023, Volume and Issue: 222(10)

Published: July 18, 2023

Serving as the power plant and signaling hub of a cell, mitochondria contain their own genome which encodes proteins essential for energy metabolism forms DNA-protein assemblies called nucleoids. Mitochondrial DNA (mtDNA) exists in multiple copies within each cell ranging from hundreds to tens thousands. Maintaining mtDNA homeostasis is vital healthy cells, its dysregulation causes human diseases. However, players involved regulating maintenance are largely unknown though core components replication machinery have been characterized. Here, we identify C17orf80, functionally uncharacterized protein, critical player maintaining homeostasis. C17orf80 primarily localizes mitochondrial nucleoid foci exhibits robust double-stranded binding activity throughout genome, thus constituting bona fide new protein. It controls levels by promoting plays important roles proliferation. Our findings provide potential target therapeutics diseases associated with defective control.

Language: Английский

C17orf80 binds the mitochondrial genome to promote its replication DOI
Hao Wu, Wenshuo Zhang, Fengli Xu

et al.

The Journal of Cell Biology, Journal Year: 2023, Volume and Issue: 222(10)

Published: July 18, 2023

Serving as the power plant and signaling hub of a cell, mitochondria contain their own genome which encodes proteins essential for energy metabolism forms DNA-protein assemblies called nucleoids. Mitochondrial DNA (mtDNA) exists in multiple copies within each cell ranging from hundreds to tens thousands. Maintaining mtDNA homeostasis is vital healthy cells, its dysregulation causes human diseases. However, players involved regulating maintenance are largely unknown though core components replication machinery have been characterized. Here, we identify C17orf80, functionally uncharacterized protein, critical player maintaining homeostasis. C17orf80 primarily localizes mitochondrial nucleoid foci exhibits robust double-stranded binding activity throughout genome, thus constituting bona fide new protein. It controls levels by promoting plays important roles proliferation. Our findings provide potential target therapeutics diseases associated with defective control.

Language: Английский

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