bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 18, 2024
Abstract
The
ventral
nerve
cord
(VNC)
of
newly
hatched
C.
elegans
contains
22
motoneurons
organized
into
three
distinct
classes:
DD,
DA,
and
DB,
that
show
stereotypical
positioning
arrangement
along
its
length.
VNC
represents
a
genetically
tractable
model
to
investigate
mechanisms
involved
in
neuron
sorting
positioning.
However,
accurately
efficiently
mapping
quantifying
all
motoneuron
positions
within
large
datasets
is
major
challenge.
Here,
we
introduce
VNC-Dist,
semi-automated
software
toolbox
designed
overcome
the
limitations
subjective
analysis
microscopy.
VNC-Dist
uses
an
annotator
for
localization
automated
contour-based
method
measuring
relative
distances
neurons
based
on
deep
learning
numerical
analysis.
To
demonstrate
robustness
versatility
applied
it
multiple
genetic
mutants
known
disrupt
VNC.
This
will
enable
acquisition
neuronal
positioning,
thereby
advancing
investigations
cellular
molecular
control
Physics of Fluids,
Journal Year:
2024,
Volume and Issue:
36(5)
Published: May 1, 2024
Unveiling
the
underlying
governing
equations
of
nonlinear
dynamic
systems
remains
a
significant
challenge.
Insufficient
prior
knowledge
hinders
determination
an
accurate
candidate
library,
while
noisy
observations
lead
to
imprecise
evaluations,
which
in
turn
result
redundant
function
terms
or
erroneous
equations.
This
study
proposes
framework
robustly
uncover
open-form
partial
differential
(PDEs)
from
limited
and
data.
The
operates
through
two
alternating
update
processes:
discovering
embedding.
phase
employs
symbolic
representation
novel
reinforcement
learning
(RL)-guided
hybrid
PDE
generator
efficiently
produce
diverse
PDEs
with
tree
structures.
A
neural
network-based
predictive
model
fits
system
response
serves
as
reward
evaluator
for
generated
PDEs.
higher
rewards
are
utilized
iteratively
optimize
via
RL
strategy
best-performing
is
selected
by
parameter-free
stability
metric.
embedding
integrates
initially
identified
process
physical
constraint
into
robust
training.
traversal
trees
automates
construction
computational
graph
without
human
intervention.
Numerical
experiments
demonstrate
our
framework's
capability
highly
data
outperform
other
physics-informed
discovery
methods.
work
opens
new
potential
exploring
real-world
understanding.
Deleted Journal,
Journal Year:
2024,
Volume and Issue:
1(2), P. 100016 - 100016
Published: May 22, 2024
Aortic
dissection
is
a
life-threatening
event
that
responsible
for
significant
morbidity
and
mortality
in
individuals
ranging
age
from
children
to
older
adults.
A
better
understanding
of
the
complex
hemodynamic
environment
inside
aorta
enables
clinicians
assess
patient-specific
risk
complications
administer
timely
interventions.
In
this
study,
we
propose
develop
validate
new
computational
framework,
warm-start
physics-informed
neural
networks
(WS-PINNs),
address
limitations
current
approaches
analyzing
hemodynamics
false
lumen
(FL)
type
B
aortic
vessels
reconstructed
apolipoprotein
null
mice
infused
with
AngII,
thereby
significantly
reducing
amount
required
measurement
data
eliminating
dependency
predictions
on
accuracy
availability
inflow/outflow
boundary
conditions.
Specifically,
demonstrate
WS-PINN
models
allow
us
focus
assessing
3D
flow
field
FL
without
modeling
true
various
branched
vessels.
Furthermore,
investigate
impact
spatial
temporal
resolutions
MRI
prediction
PINN
model,
which
can
guide
acquisition
reduce
time
financial
costs.
Finally,
consider
use
transfer
learning
provide
faster
results
when
looking
at
similar
but
geometries.
Our
indicate
proposed
framework
enhance
capacity
analysis
dissections,
promise
eventually
leading
improved
prognostic
ability
development
aneurysms.
Physical Review Research,
Journal Year:
2025,
Volume and Issue:
7(1)
Published: Feb. 13, 2025
The
Gross-Pitaevskii
equation
(GPE),
a
specialized
form
of
the
nonlinear
Schrödinger
(NLSE),
plays
pivotal
role
in
quantum
mechanics,
optics,
and
condensed
matter
physics,
modeling
phenomena
such
as
superfluidity,
turbulence,
solitons,
while
serving
cornerstone
for
advancing
study
wave
propagation
its
technological
applications.
In
this
paper,
we
propose
solver,
Complex-Valued
Physics
Informed
Neural
Network
(CV-PINN)
NLSEs
using
physics-informed
learning
machines
with
complex
representation.
This
method
integrates
values
algebraic
properties
directly
into
neural
network,
structure
mirroring
computation
process
numbers,
thereby
significantly
enhancing
ability
to
effectively
solve
problems.
Additionally,
introduce
collocation-point
sampling
called
Predictive
Dynamic
Monitoring
Sampling
(PDM
sampling),
which
adaptively
adjusts
distribution
collocation
points
during
training
based
on
model's
historical
performance.
We
conducted
extensive
empirical
evaluations
CV-PINN
PDM
series
NLSE/GPEs
(a
total
16
solved
examples).
Compared
traditional
real-valued
PINN,
demonstrated
higher
accuracy,
faster
convergence,
greater
robustness,
better
stability
these
cases.
Moreover,
proved
be
effective
preventing
model
degradation
convergence
speed
predictive
accuracy
when
compared
methods.
advancement
provides
an
approach
perspective
solving
partial
differential
equations,
offering
insights
broader
application
PINNs
across
various
fields.
Published
by
American
Physical
Society
2025