International review of neurobiology, Journal Year: 2021, Volume and Issue: unknown, P. 29 - 55
Published: Jan. 1, 2021
Language: Английский
The Lancet Child & Adolescent Health, Journal Year: 2020, Volume and Issue: 5(1), P. 47 - 87
Published: Oct. 13, 2020
Language: Английский
Citations
225
Biological Psychiatry, Journal Year: 2019, Volume and Issue: 87(1), P. 64 - 73
Published: Dec. 2, 2019
Language: Английский
Citations
182
Frontiers in Behavioral Neuroscience, Journal Year: 2021, Volume and Issue: 15
Published: Feb. 24, 2021
The brain anxiety network is composed of a number interconnected cortical regions that detect threats and execute appropriate defensive responses via projections to the shell nucleus accumbens (NAcSh), dorsolateral region bed stria terminalis (BSTDL) lateral central amygdala (CeL). paraventricular thalamus (PVT) anatomically positioned integrate threat- arousal-related signals from cortex hypothalamus then relay these neural circuits in NAcSh, BSTDL, CeL mediate responses. This review describes anatomical connections PVT support view may be critical node network. Experimental findings are reviewed showing arousal peptides orexins (hypocretins) act at promote avoidance potential especially following exposure rats single episode footshocks. Recent experimental discussed which show neurons provide divergent subcortical behaviors projection NAcSh for enhanced social displayed exposed A theoretical model proposed how integrates hypothalamic modulate behavioral associated with other challenging situations.
Language: Английский
Citations
113
Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)
Published: Aug. 21, 2023
Abstract Responses of the insular cortex (IC) and amygdala to stimuli positive negative valence are altered in patients with anxiety disorders. However, neural coding both by IC neurons remains unknown. Using fiber photometry recordings mice, we uncover a selective increase activity projection anterior (aIC), but not posterior (pIC) section, when animals exploring anxiogenic spaces, this is proportional level mice. Neurons aIC also respond valence, strength response strong mice levels anxiety. ex vivo electrophysiology, characterized connection basolateral (BLA), employed projection-specific optogenetics reveal properties aIC-BLA neurons. Finally, identified that activated as well aversive stimuli, activities positively correlated. Altogether, common neurobiological substrate linking anxiety-related information behaviors, which provides starting point understand how alterations these populations contribute psychiatric
Language: Английский
Citations
50
Mayo Clinic Proceedings Innovations Quality & Outcomes, Journal Year: 2024, Volume and Issue: 8(1), P. 97 - 111
Published: Jan. 21, 2024
Lifestyle Medicine (LM) is a rapidly growing discipline that focuses on the role of lifestyle factors in preventing, managing, and reversing chronic disease. At this point field's evolution, there strong evidence 6 pillars LM-a whole-food, plant-predominant eating pattern, physical activity, restorative sleep, stress management, avoidance risky substances, positive social connections-are central creation maintenance health. Previous publications, many them randomized controlled studies meta-analyses, have solidified base for use within field LM. As data emerged, so did its governing body, American College (ACLM), with it rich history began to unfold. Several articles been written early ACLM growth field; however, review article explores foundation LM, aiming provide comprehensive understanding relevance impact health care. It underscores landmark defined provides road map detailing national global barriers areas potential future growth.
Language: Английский
Citations
23
Scientific Reports, Journal Year: 2021, Volume and Issue: 11(1)
Published: Sept. 29, 2021
Abstract Anxiety is recognized as a major health issue and quite prevalent among older adults. An efficient way to manage anxiety abdominal breathing. Breathing exercises seem reduce increase parasympathetic activity assessed by HRV indexes. Yet, the effect of breathing on physiological stress (HRV) in adults remains poorly understood. Therefore, aim this study test effects deep slow (DSB, low inhale/exhale ratio) (n = 22) comparison with younger ones 25). DSB increased significantly HFpower reduced state both Interestingly, HF power was higher than ones. As expected, ratio being not equal, RMSSD did following DSB. Thus, we provide evidence suggesting that more beneficial restore vagal outflow. Despite future work required, those results relevant clinical application leads promote successfull aging.
Language: Английский
Citations
84
Autonomic Neuroscience, Journal Year: 2021, Volume and Issue: 235, P. 102870 - 102870
Published: Aug. 25, 2021
Language: Английский
Citations
81
Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 127, P. 184 - 192
Published: April 27, 2021
Bipolar disorder (BD) and borderline personality (BPD) are serious prevalent psychiatric diseases that share common phenomenological characteristics: symptoms (such as anxiety, affective lability or emotion dysregulation), neuroimaging features, risk factors comorbidities. While several studies have focused on the link between stress peripheral inflammation in other disorders such anxiety depression, fewer explored this relationship BD BPD. This review reports evidence showing an interplay immune dysregulation, stress, how altered acute neuroendocrine response may exist these disorders. Moreover, we highlight limitations confounding of existing discuss multidirectional hypotheses either suggest primum movens BPD pathophysiology, a consequence pathophysiology diseases. Untangling associations implementing transdiagnostic approach will diagnostic, therapeutic prognostic implications for patients.
Language: Английский
Citations
80
Journal of Health Psychology, Journal Year: 2021, Volume and Issue: 27(8), P. 1913 - 1925
Published: April 29, 2021
The new Coronavirus has impacted people's lifestyles, stress, and well-being. Thus, they need personal positive resources to help them during challenging circumstances. With this longitudinal study on 290 participants, we analyzed the relationship between psychological capital (PsyCap), measured at beginning of lockdown period some indicators mental health (depression, anxiety, satisfaction with life) after 2 months. Moreover, examined whether stress (at Time 2) mediates relationships. Following structural equation modeling (SEM) analyses, results show that PsyCap a significant effect life negative effects depression anxiety. Stress mediated all
Language: Английский
Citations
78
Biomedicines, Journal Year: 2021, Volume and Issue: 9(10), P. 1313 - 1313
Published: Sept. 24, 2021
Attention-deficit/hyperactivity disorder (ADHD) is a prevalent and serious neurodevelopmental characterized by symptoms of inattention and/or hyperactivity/impulsivity. Chronic childhood stress involved in ADHD development, highly comorbid with anxiety. Similarly, inflammatory diseases pro-inflammatory state have been associated ADHD. However, while several works studied the relationship between peripheral inflammation affective disorders such as depression or bipolar disorder, fewer explored this association In narrative review we synthetize evidence showing an interplay stress, anxiety, immune dysregulation ADHD, discuss implications potential disrupted neuroendocrine response Moreover, highlight confounding factors limitations existing studies on topic critically debate multidirectional hypotheses that either suggest inflammation, anxiety cause pathophysiology consequence disease. Untangling these relationships will diagnostic, therapeutic prognostic for patients.
Language: Английский
Citations
78