Contribution of Amygdala Histone Acetylation in Early Life Stress-Induced Visceral Hypersensitivity and Emotional Comorbidity

Frontiers in Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: May 6, 2022

Patients with irritable bowel syndrome (IBS) experience not only enhanced visceral pain but also emotional comorbidities, such as anxiety and depression. Early life stress (ELS) is a high-risk for the development of IBS. Literatures have reported an important epigenetic modulation in sustaining extrinsic phenotypes. The amygdala closely related to regulation functions experiences. In this study, we hypothesized that ELS-induced reprogramming inappropriate adaptation histone acetylation modification may result hypersensitivity anxiety-like behaviors ELS rats. To test hypothesis, model rats was established by neonatal colorectal dilatation (CRD). Visceral assessed based on electromyography response abdominal external oblique muscle CRD. Emotional comorbidities were examined using elevated plus maze test, open field sucrose preference test. Trichostatin A (TSA) C646 microinjected into central (CeA) individually investigate effects different levels emotion. We found CRD resulted after adulthood. Inhibiting deacetylases (HDACs) CeA TSA sensitivity did affect behaviors, whereas inhibiting HAT attenuated Interestingly, treatment induced control Western blot showed expressions acetylated 9 residue Histone 3 (H3K9) protein kinase C zeta type (PKMζ) higher compared those controls. administration PKMζ inhibitor ZIP Furthermore, expression Finally, western immunofluorescence results indicated decrease HDAC1 HDAC2 expressions, HDAC3 expression, contributed enhancement Our support our hypothesis amygdala-enhanced early rats, reversing abnormal mechanisms be crucial relieve chronic symptoms

Language: Английский

---

Cadmium does not affect post-hatching maternal care or early offspring development in earwigs

Behavioral Ecology, Journal Year: 2023, Volume and Issue: 34(3), P. 399 - 407

Published: March 16, 2023

Abstract Anthropogenic pollution is steadily increasing and has a major impact on biodiversity. Chemical pollutants in particular affect many reproductive, physiological, survival traits wide range of organisms. However, the effects behavioral have been less studied, although they could wide-ranging negative from individual to community level. Here, we attempted fill this knowledge gap by investigating effect common heavy metal pollutant, cadmium, post-hatching maternal care juvenile development European earwig Forficula auricularia. We fed 108 families with five different cadmium concentrations (0, 12.5, 25, 50, 100 mg.L−1), measured ten parameters related offspring care, non-care behaviors, investment two (offspring weight gain survival). Somewhat surprisingly, found no ingestion any measured, except for self-grooming behavior. In particular, group members did not result an overall decrease expression contaminated mothers or higher level received offspring. By contrast, highest dose showed increase self-grooming, probably due stress toxic ingestion. Overall, our study raises questions about whether how parent–offspring interactions can alter environments social species.

Language: Английский

---

Biological Pathways Associated with Vitamins in Autism Spectrum Disorder

Neurotoxicity Research, Journal Year: 2023, Volume and Issue: 41(6), P. 730 - 740

Published: Oct. 21, 2023

Language: Английский

---

Prenatal allergic inflammation in rats confers sex-specific alterations to oxytocin and vasopressin innervation in social brain regions

Hormones and Behavior, Journal Year: 2023, Volume and Issue: 157, P. 105427 - 105427

Published: Sept. 22, 2023

Language: Английский

---

Autistic-like behaviors are attenuated by agmatine consumption during pregnancy: Assessment of oxidative stress profile and histopathological changes in the prefrontal cortex and CA1 region of the hippocampus.

PubMed, Journal Year: 2024, Volume and Issue: 27(3), P. 335 - 342

Published: Jan. 1, 2024

Due to the crucial role of polyamines during fetal growth and development, we aimed determine effect prenatal administration agmatine, an endogenous active metabolite arginine, a nutritional supplement, on autistic-like behaviors, oxidative-anti-oxidative profile, histopathological changes prefrontal cortex (PFC) CA1 area hippocampus in valproic acid (VPA) model autism male rats.

Language: Английский

---

Paraventricular hypothalamic vasopressin neurons induce self-grooming in mice

Molecular Brain, Journal Year: 2022, Volume and Issue: 15(1)

Published: May 23, 2022

Abstract Self-grooming plays an essential role in hygiene maintenance, thermoregulation, and stress response. However, the neural populations involved self-grooming remain largely unknown. The paraventricular hypothalamic nucleus (PVH) has been implicated regulation of self-grooming. Arginine vasopressin-producing neurons are among major neuronal PVH (PVH AVP ), which play important roles water homeostasis, blood pressure regulation, feeding, Here, we report critical induction Optogenetic activation immediately induced freely moving mice. Chemogenetic these also increased time spent In contrast, their chemogenetic inhibition significantly reduced naturally occurring self-grooming, suggesting that -induced grooming physiological relevance. Notably, optogenetic triggered over other adaptive behaviors, such as voracious feeding by fasting social interaction with female Thus, our study proposes novel regulating behavior and, consequently, maintenance Furthermore, uncontrolled may be potentially relevant to diseases characterized compulsive behaviors impaired interaction, autism, obsessive–compulsive disorder, anorexia nervosa.

Language: Английский

---

Activation of basolateral amygdala to anterior cingulate cortex circuit alleviates MK-801 induced social and cognitive deficits of schizophrenia

Frontiers in Cellular Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: Dec. 22, 2022

Schizophrenia is a severe psychiatric disorder with high prevalence worldwide, however, its pathogenesis remains poorly understood. In this study, we used the non-competitive NMDA receptor antagonist MK-801 to induce schizophrenia-like behaviors and confirmed that mice exhibited stereotypic rotational behavior hyperlocomotion, social interaction defects cognitive dysfunction, similar clinical symptoms in patients. Here, anterior cingulate cortex (ACC) basolateral amygdala (BLA) were involved induced by MK-801. Furthermore, BLA sent glutamatergic projection ACC. Chemogenetic optogenetic regulation of BLA-ACC projecting neurons affected deficits but not MK-801-treated mice. Overall, our study revealed circuit plays major role may be potential target for treating schizophrenia-related symptoms.

Language: Английский

---

Anxiolytic-like effects of citral in the mouse elevated plus maze: involvement of GABAergic and serotonergic transmissions

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2022, Volume and Issue: 396(2), P. 301 - 309

Published: Nov. 2, 2022

Language: Английский

---

The longitudinal behavioral effects of acute exposure to galactic cosmic radiation in female C57BL/6J mice: implications for deep space missions, female crews, and potential antioxidant countermeasures

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 15, 2024

Galactic cosmic radiation (GCR) is an unavoidable risk to astronauts that may affect mission success. Male rodents exposed 33-beam-GCR (33-GCR) show short-term cognitive deficits but reports on female and long-term assessment lacking. Here we asked: What are the longitudinal behavioral effects of 33-GCR mice? Also, can antioxidant/anti-inflammatory compound mitigate impact 33-GCR? Mature (6-month-old) C57BL/6J mice received antioxidant CDDO-EA (400 µg/g food) or a control diet (vehicle, Veh) for 5 days either Sham-irradiation (IRR) whole-body (0.75Gy) 4th day. Three-months post-IRR, underwent two touchscreen-platform tests: 1) location discrimination reversal (which tests behavior pattern separation flexibility, abilities reliant dentate gyrus) 2) stimulus-response learning/extinction. Mice then arena-based (e.g. open field, 3-chamber social interaction). At experiment end (14.25-month post-IRR), neurogenesis was assessed (doublecortin-immunoreactive [DCX+] gyrus neurons). Female Veh/Sham vs. Veh/33-GCR had similar (% correct 1st reversal). There were diet: CDDO-EA/Sham CDDO-EA/33-GCR better their respective groups (Veh/Sham, Veh/33-GCR), flexibility (reversal number) mice. Notably, one effect/CDDO-EA countereffect also emerged: worse learning (days completion) all other groups, including In general, normal anxiety-like behavior, exploration, habituation novel environments. change in neurogenesis: fewer DCX+ immature neurons Our study implies space crew's mission-relevant processes potential dietary countermeasure space-radiation CNS risks.

Language: Английский

---

Ventral zona incerta parvalbumin neurons modulate sensory-induced and stress-induced self-grooming via input-dependent mechanisms in mice

iScience, Journal Year: 2024, Volume and Issue: 27(7), P. 110165 - 110165

Published: June 4, 2024

Language: Английский

---