Analysis of Rodent Grooming and Its Microstructure in Modern Neurobiological Studies

Journal of Evolutionary Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 60(3), P. 1125 - 1143

Published: May 1, 2024

Language: Английский

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A subthalamo-parabrachial glutamatergic pathway is involved in stress-induced self-grooming in mice

Acta Pharmacologica Sinica, Journal Year: 2023, Volume and Issue: 44(11), P. 2169 - 2183

Published: June 15, 2023

Language: Английский

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Effects of Five Coumarins and Standardized Extracts from Tagetes lucida Cav. on Motor Impairment and Neuroinflammation Induced with Cuprizone

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(10), P. 1391 - 1391

Published: Sept. 30, 2023

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) with no curative treatment, and available therapies aim to modify course disease. It has been demonstrated that extracts Tagetes lucida have immunomodulatory neuroprotective effects. This work induced motor damage neuroinflammation in male BALB/c mice by oral administration cuprizone (CPZ) (40 mg/kg) for five weeks. In addition, coumarins (25 were used control these variables; during experiment, animals subject behavioral tests, at end 5 weeks, from each group measure integrity biological barriers (brain, kidneys, spleen) through extravasation test blue Evans dye. another animals, ELISA method measured brain concentrations IL-1β, IL-4, IL-10, TNF-α. The results presented here allow us conclude IC, HN, PE, DF, SC exert a effect controlling increasing expression IL-4 IL-10 decreasing IL-1β TNF-α; notably, treatments also protect organs vascular permeability increase, mainly BBB, CPZ-induced experimental encephalomyelitis (VEH * p < 0.05). However, more studies must be carried out elucidate molecular mechanisms pharmacological effects this Mexican medicinal plant.

Language: Английский

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Dual-Stream Spatiotemporal Networks with Feature Sharing for Monitoring Animals in the Home Cage

Sensors, Journal Year: 2023, Volume and Issue: 23(23), P. 9532 - 9532

Published: Nov. 30, 2023

This paper presents a spatiotemporal deep learning approach for mouse behavioral classification in the home-cage. Using series of dual-stream architectures with assorted modifications optimal performance, we introduce novel feature sharing that jointly processes streams at regular intervals throughout network. The dataset focus is an annotated, publicly available singly-housed mouse. We achieved even better accuracy by ensembling best performing models; Inception-based network and attention-based network, both which utilize this attribute. Furthermore, demonstrate through ablation studies all models, consistently outperform conventional having standalone streams. In particular, inception-based showed higher gains their increase anywhere between 6.59% 15.19%. best-performing models were also further evaluated on other datasets.

Language: Английский

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The role of the dorsal striatum in a mouse model for fragile X syndrome: Behavioral and dendritic spine assessment

Brain Research, Journal Year: 2022, Volume and Issue: 1795, P. 148060 - 148060

Published: Aug. 27, 2022

Language: Английский

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