Acute Supplementation of Soluble Mango Leaf Extract (Zynamite® S) Improves Mental Performance and Mood: A Randomized, Double-Blind, Placebo-Controlled Crossover Study DOI Creative Commons
Yolanda Castellote‐Caballero, Ana Beltrán-Arranz, Agustín Aibar‐Almazán

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(4), P. 571 - 571

Published: April 14, 2025

Background/Objectives: A mango (Mangifera indica) leaf extract (Zynamite®), rich in the polyphenol mangiferin, has been demonstrated to modulate brain activity, boost cognitive function, and reduce mental fatigue. Research evidence supports that improving solubility of this could significantly enhance its efficacy as an active ingredient. This study examined effects a soluble version Zynamite®, Zynamite® S (Zyn-S), on function mood young adults at low doses. Methods: total 119 university students were enrolled study. Participants randomly assigned receive either 100 mg, 150 or placebo double-blind crossover design. Short- long-term memory evaluated using Rey Auditory Verbal Learning Test (RAVLT), executive functions with Trail Making (TMT), processing speed Digit Symbol Substitution (DSST), selective attention Stroop Color Word Test. Additionally, was assessed Spanish short Profile Mood States (POMS). All these assessments conducted before taking product 30 min, 3 h, 5 h post-intake. Results: The results participants who received experienced significant improvements reduced tension, depression, confusion, suggesting enhancement clarity overall emotional well-being. Both interventions also improved flexibility. However, no differences observed short- verbal memory. Conclusions: In summary, findings support natural nootropic capable acutely key balance doses adults, sustained for least five hours.

Language: Английский

The Journey of the Default Mode Network: Development, Function, and Impact on Mental Health DOI Creative Commons

Felipe Rici Azarias,

Gustavo Henrique Doná Rodrigues Almeida, Luana Félix de Melo

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(4), P. 395 - 395

Published: April 10, 2025

The Default Mode Network has been extensively studied in recent decades due to its central role higher cognitive processes and relevance for understanding mental disorders. This neural network, characterized by synchronized coherent activity at rest, is intrinsically linked self-reflection, exploration, social interaction, emotional processing. Our of the DMN extends beyond humans non-human animals, where it observed various species, highlighting evolutionary basis adaptive significance throughout phylogenetic history. Additionally, plays a crucial brain development during childhood adolescence, influencing fundamental processes. literature review aims provide comprehensive overview DMN, addressing structural, functional, aspects, as well impact from infancy adulthood. By gaining deeper organization function we can advance our knowledge mechanisms that underlie cognition, behavior, health. This, turn, lead more effective therapeutic strategies range neuropsychiatric conditions.

Language: Английский

Citations

1
Relationship between head nurse leadership and nurses’ burnout: parallel mediation of job demands and job resources among clinical nurses DOI Creative Commons

He Jiaqing,

Tian Yusheng,

Zhai Mimi

et al.

BMC Nursing, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 1, 2025

Many elements in the workplace contribute to nurses' burnout experiences, affecting patient safety and healthcare organizations' efficiency. Leaders' presence conduct are most potent "master" factors every work setting. Although previous studies have shown that head nurse leadership, job demands, resources, significantly related, interaction mechanism remains unclear. This study investigates parallel mediating roles of demands resources between leadership nursing staff. A cross-sectional, anonymous, confidential online survey was conducted from March June 2024 collect data 579 registered nurses four hospitals Hunan provinces. The independent variable variables were dependent burnout. Parallel mediation analysis performed using PROCESS macro SPSS. found negatively relates suggests play relationship As predicted, weakened through contributed demands. finding highlights importance decreasing reveals two potential mechanisms which is related By understanding role interventions can be targeted improve mental health.

Language: Английский

Citations

0
NEUROBIOLOGICAL ASPECTS OF PATHOGENETIC MECHANISMS IN THE DEVELOPMENT OF POST-TRAUMATIC STRESS DISORDER (LITERATURE REVIEW) DOI Creative Commons
Oleksandr Oleshko, Kristina Berladir, Tetiana Oleshko

et al.

Eastern Ukrainian Medical Journal, Journal Year: 2025, Volume and Issue: 13(1), P. 39 - 54

Published: Jan. 1, 2025

Post-traumatic stress disorder (PTSD) occurs as a result of exposure to life-threatening traumatic event or situation involving violence. The main manifestations PTSD are obsessive re-experiencing the event, increased nervous arousal, avoidance stimuli related emotional and cognitive disorders that persist for long time. This mental is exhausting causes changes make it difficult sometimes impossible patients with function professionally socially. results in significant clinical burden high socioeconomic costs. Materials methods. authors have reviewed more than 100 scientific papers from world literature on problems diagnosis, symptoms, pathophysiological neurobiological mechanisms play an important role development can be used key elements choice treatment measures. Results. multifactorial disease, therefore, numerous factors involved its occurrence progression. immediate response activation neuroendocrine autonomic systems release adrenaline norepinephrine. involvement hypothalamic-pituitary-adrenal system subsequent secretion cortisol may trigger development. A link has been found between activity noradrenergic system, glucocorticoid exposure, impaired interaction neurons amygdala prefrontal cortex. In addition, glucocorticoids associated immune neuroinflammation. Inflammatory cytokines regulate modify functioning neurotransmitters such serotonin dopamine, which contributes onset progression symptoms. Conclusions. data large number studies allow us confirm following pathogenesis PTSD. These include vegetative regulation, dysfunction immunological regulatory inflammatory mechanisms, dysregulation monoaminergic transmission system. Further study pathogenetic pathways will better implementation strategy medical care

Language: Английский

Citations

0
Chronic stress-induced neuroplasticity in the prefrontal cortex: Structural, functional, and molecular mechanisms from development to aging DOI
Sami A. Algaidi

Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 149461 - 149461

Published: Jan. 1, 2025

Language: Английский

Citations

0
The Role of Stress Management in the Acquisition of English as a Foreign Language for Children with ADHD: A Longitudinal Case Study DOI Creative Commons
Dalia Elleuch

Heliyon, Journal Year: 2025, Volume and Issue: unknown, P. e43060 - e43060

Published: March 1, 2025

Language: Английский

Citations

0
Allostatic load, a measure of cumulative physiological stress, impairs brain structure but not β-accumulation in older adults: an exploratory study DOI Creative Commons
Cassandre Palix, Léa Chauveau,

Francesca Felisatti

et al.

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: March 31, 2025

Introduction Allostatic load (AL) is a composite score of progressive physiological dysregulations in response to long-term exposure everyday stress. Despite growing interest, limited research has focused on links with cerebral and cognitive aspects aging markers sensitive Alzheimer’s disease (AD) healthy elderly population multimodal approach. Methods At baseline, 111 older adults (without impairment) from the Age-Well trial completed blood anthropometric collection, assessments neuroimaging within 3 months. Results AL was negatively associated gray matter volume white integrity frontal temporal regions poorer attentional performance. Discussion linked structural brain aging- stress-sensitive but not AD-related ( β -amyloid load) only two AD-sensitive adults. These results highlight potential interest as index stress-induced aging.

Language: Английский

Citations

0
Acute Supplementation of Soluble Mango Leaf Extract (Zynamite® S) Improves Mental Performance and Mood: A Randomized, Double-Blind, Placebo-Controlled Crossover Study DOI Creative Commons
Yolanda Castellote‐Caballero, Ana Beltrán-Arranz, Agustín Aibar‐Almazán

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(4), P. 571 - 571

Published: April 14, 2025

Background/Objectives: A mango (Mangifera indica) leaf extract (Zynamite®), rich in the polyphenol mangiferin, has been demonstrated to modulate brain activity, boost cognitive function, and reduce mental fatigue. Research evidence supports that improving solubility of this could significantly enhance its efficacy as an active ingredient. This study examined effects a soluble version Zynamite®, Zynamite® S (Zyn-S), on function mood young adults at low doses. Methods: total 119 university students were enrolled study. Participants randomly assigned receive either 100 mg, 150 or placebo double-blind crossover design. Short- long-term memory evaluated using Rey Auditory Verbal Learning Test (RAVLT), executive functions with Trail Making (TMT), processing speed Digit Symbol Substitution (DSST), selective attention Stroop Color Word Test. Additionally, was assessed Spanish short Profile Mood States (POMS). All these assessments conducted before taking product 30 min, 3 h, 5 h post-intake. Results: The results participants who received experienced significant improvements reduced tension, depression, confusion, suggesting enhancement clarity overall emotional well-being. Both interventions also improved flexibility. However, no differences observed short- verbal memory. Conclusions: In summary, findings support natural nootropic capable acutely key balance doses adults, sustained for least five hours.

Language: Английский

Citations

0