Estimating the True Effect of Lifestyle Risk Factors for Myopia: A Longitudinal Study of UK Children DOI Creative Commons
Jeremy A. Guggenheim, Rosie Clark, Anna Pease

et al.

Translational Vision Science & Technology, Journal Year: 2024, Volume and Issue: 13(11), P. 10 - 10

Published: Nov. 13, 2024

Purpose: Lifestyle risk factors are implicated in driving the current surge myopia prevalence yet, paradoxically, known explain little of variation refractive error population. Here, we applied "instrumental variable" (IV) methods designed to avoid reverse causation and decrease confounding bias, gauge lifestyle factor effect sizes. Methods: Three (time outdoors, time reading, sleep duration) were assessed participants Avon Longitudinal Study Parents Children: a cross-sectional sample 2302 children aged 15 years old longitudinal 3086 followed from age 7 years. Seven IVs considered jointly: dog ownership, cat bedtime variability, birth order, polygenic scores quantifying genetic predisposition spend additional fulltime education, asleep overnight. Results: Risk sizes 4-fold 9-fold higher IV analyses compared with conventional regression analyses. In analyses, one extra hour spent outdoors every day during childhood was associated shift toward hyperopia +0.53 +0.94 diopters (D), whereas 1 reading −0.44 −0.88 D. There inconsistent evidence that duration influenced error. Conclusions: Myopia effects underestimated up this sample, Translational Relevance: We speculate for have been past studies.

Language: Английский

The association between sleep duration and myopia among Chinese school-age students: mediation effect of physical activity DOI Creative Commons
H. Q. Feng,

Yuexia Gao,

Na An

et al.

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 3, 2025

This study aimed to investigate the relationship between sleep duration and myopia in school-age students, as well observe role of physical activity a mediating variable myopia. Using multistage stratified sampling, 26,020 students Jiangsu Province, ages 7-18, were selected for this cross-sectional survey. Each participant completed standardized interview which their asked about vision, level average hours per day over past month. Visual acuity examinations conducted by testing team's ophthalmology professionals they categorized into two groups based on pre-set criteria: myopic non-myopic. Sleep was classified 3 categories: <8 h/d, 8-10 >10 h/d. The Pearson's chi-square tests used examine differences incidence among participants. Binary multifactorial logistic regression adjusted potential confounding variables variety factors. effects analyzed using AMOS model. In study, higher females than males, it also increased with age. Those who slept h/d had greatest rate (85.69%) compared those for≥8 (p < 0.001). found be adversely correlated (sleep = h/d: OR 0.68, p 0.01; > 10 0.48, 0.01) after controlling confounders like gender, age, BMI-z score (Body Mass Index Score). Physical at high intensity not moderate protective factor against High-intensity acted mediator negative association (a, b, c' all 0.05). There is correlation that high-intensity mediates

Language: Английский

Citations

0
Students’ association of poor eye-use behavior with myopia: focus on study phase DOI Creative Commons
Tingting Li, Feng Yang, Xiaoling Liu

et al.

BMC Ophthalmology, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 23, 2025

To investigate the prevalence of poor eye-use behavior and myopia in Chinese students, examine associations with myopia, as well its study phase differences. From March to July 2023, a total 67 910 students were selected from 56 schools 14 cities China by stratified cluster sampling. The Eye-use Behavior Evaluation Scale for Students (EBESS) was adopted students. underwent an uncorrected visual acuity examination non-cycloplegic autorefraction examination. chi-square test used compare between different groups. binary logistic regression model conducted analyze association myopia. 27.6% 53.0%, respectively. poorer higher (P < 0.001). After adjusting age, gender, sibling, parental education level, self-reported learning burden, mode travel school, physical lesson, city, usage distance mobile phone / iPad game console, reading writing distance, weekdays outdoor time, weekends analysis results showed that positively correlated (OR = 1.10, 95% CI: 1.03 ~ 1.19). According further analysis, primary school 1.35, 1.20 1.50) senior high 1.28, 1.08 1.51), However, kindergarten junior there no statistically significant difference > 0.05). Poor potential risk factor this effect significantly phases. This suggests future research should establish interventions protect effects behavior.

Language: Английский

Citations

0
Effects of Insufficient Sleep on Myopia in Children: A Systematic Review and Meta-Analysis DOI Creative Commons
Xixuan Zhao, Yining He, Juzhao Zhang

et al.

Nature and Science of Sleep, Journal Year: 2024, Volume and Issue: Volume 16, P. 1387 - 1406

Published: Sept. 1, 2024

Myopia is increasingly prevalent in children. Its association with insufficient sleep has been studied, yielding inconsistent findings. This review aims to assess the of myopia and myopia-related refractive parameters A total 657 articles were identified, which 40 included systematic 33 meta-analysis. Results showed that was significantly associated an increased prevalence (odds ratio [OR] = 1.59; 95% confidence interval [CI] 1.31, 1.95;

Language: Английский

Citations

3
The causal effect of multiple lifestyles and myopia: a Mendelian randomization study DOI Creative Commons

Mengru Su,

Xi Zou,

Hai-Rong Xie

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 18, 2025

Previous studies have demonstrated that lifestyle was associated with myopia. This study used Mendelian randomization (MR) analysis to examine the causal relationships between time of computer use, outdoors in summer and winter Subsequently, univariate MR (UVMR) analyses were carried out respectively on three exposure factors myopia, results mainly based inverse-variance-weighted method. In addition, sensitivity also conducted, including heterogeneity tests, horizontal pleiotropy leave-one-out methods, evaluate stability results. Multivariate (MVMR) out. The UVMR showed two had myopia: use a risk factor, spent protective factor. However, no direct impact Furthermore, further mediation frequency solarium/sunlamp mediating factor winter-myopia, effect accounted for 36.93%. conclusion, when multiple occurred simultaneously, outdoor activities potential affected myopia through use.

Language: Английский

Citations

0
No Evidence of An Association between Genetic Factors Affecting Response to Vitamin A Supplementation and Myopia: A Mendelian Randomization Study and Meta-Analysis DOI Open Access
Xiaotong Xu, N N Liu,

Weihong Yu

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(12), P. 1933 - 1933

Published: June 18, 2024

The relationship between vitamin A supplementation and myopia has been a topic of debate, with conflicting inconclusive findings. We aimed to determine whether there is causal the risk using Mendelian randomization (MR) meta-analytical methods. Genetic variants from UK Biobank FinnGen studies associated response were employed as instrumental variables evaluate myopia. Fixed-effects meta-analysis was then used combine MR estimates multiple sources for each outcome. results found no convincing evidence support direct (odds ratio (OR) = 0.99, 95% confidence interval (CI) 0.82–1.20, I2 0%, p 0.40). analysis three out four sets analyses indicated direction effect, whereas other set suggested that higher lower (OR 0.002, CI 1.17 × 10−6–3.099, 0.096). This comprehensive study did not find valid association Vitamin may have an independent effect on myopia, but intraocular processes indirectly contribute its development.

Language: Английский

Citations

2
Risk of inappropriate causal inference in Mendelian randomization studies on myopia DOI
Bing Zhang

Eye, Journal Year: 2024, Volume and Issue: 38(15), P. 3019 - 3021

Published: June 27, 2024

Language: Английский

Citations

1
Diurnal gene expression patterns in retina and choroid distinguish myopia progression from myopia onset DOI Creative Commons
Richard A. Stone, John W. Tobias, Wenjie Wei

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(7), P. e0307091 - e0307091

Published: July 19, 2024

The world-wide prevalence of myopia (nearsightedness) is increasing, but its pathogenesis incompletely understood. Among many putative mechanisms, laboratory and clinical findings have implicated circadian biology in the etiology myopia. Consistent with a hypothesis, we recently reported marked variability diurnal patterns gene expression two crucial tissues controlling post-natal refractive development ‐ retina choroid–at onset form-deprivation chick, widely studied validated model. To extend these observations, assayed by RNA-Seq choroid during progression established unilateral chick. We every 4 hours single day from myopic contralateral control eyes. Retinal choroidal vs. eyes differed strikingly at discrete times day. Very few differentially expressed genes occurred more than one time either tissue progressing Similarly, Gene Set Enrichment Analysis pathways varied markedly Some coincided candidate for human myopia, only partially corresponded previously identified onset. Considering other genetics epidemiology, results further link to myopia; they also point important mechanistic differences between Future investigations should systematically incorporate mechanisms studying seeking effective treatments normalize eye growth children.

Language: Английский

Citations

1
Estimating the True Effect of Lifestyle Risk Factors for Myopia: A Longitudinal Study of UK Children DOI Creative Commons
Jeremy A. Guggenheim, Rosie Clark, Anna Pease

et al.

Translational Vision Science & Technology, Journal Year: 2024, Volume and Issue: 13(11), P. 10 - 10

Published: Nov. 13, 2024

Purpose: Lifestyle risk factors are implicated in driving the current surge myopia prevalence yet, paradoxically, known explain little of variation refractive error population. Here, we applied "instrumental variable" (IV) methods designed to avoid reverse causation and decrease confounding bias, gauge lifestyle factor effect sizes. Methods: Three (time outdoors, time reading, sleep duration) were assessed participants Avon Longitudinal Study Parents Children: a cross-sectional sample 2302 children aged 15 years old longitudinal 3086 followed from age 7 years. Seven IVs considered jointly: dog ownership, cat bedtime variability, birth order, polygenic scores quantifying genetic predisposition spend additional fulltime education, asleep overnight. Results: Risk sizes 4-fold 9-fold higher IV analyses compared with conventional regression analyses. In analyses, one extra hour spent outdoors every day during childhood was associated shift toward hyperopia +0.53 +0.94 diopters (D), whereas 1 reading −0.44 −0.88 D. There inconsistent evidence that duration influenced error. Conclusions: Myopia effects underestimated up this sample, Translational Relevance: We speculate for have been past studies.

Language: Английский

Citations

0