Nanotoxicology: developments and new insights DOI

Henry N. Abonyi,

Ikechukwu Emmanuel Peter, Akachukwu Marytheresa Onwuka

et al.

Nanomedicine, Journal Year: 2024, Volume and Issue: 20(2), P. 225 - 241

Published: Dec. 26, 2024

The use of nanoparticles (NPs) in treatment diseases have increased exponentially recently, giving rise to the science nanomedicine. safety these NPs humans has also led nanotoxicology. Due a dearth both readily available models and precise bio-dispersion characterization techniques, nanotoxicological research obviously been constrained. However, ensuing years were notable for emergence improved synthesis methods tools. Major advances made linking certain physical variables, paralleling improvements size, shape, or coating factors resulting physiological reactions. Although significant progress contribution development nanotoxicology, however, it faces numerous difficulties technical constraints distinct from those conventional toxicological assessment as attempts improve therapeutic effects medicines. Determining thorough standards, standardizing dosimetry, assessing kinetics ions dissolving enhancing accuracy vitro-in vivo correlation efficiency, defining restrictions on exposure protection are some most important pressing concerns. This article will explore past advancement potential prospects standard models, emphasizing findings earlier studies examining current challenges, insight way forward.

Language: Английский

Developmental Neurotoxicity as a Case Example for a Six-Step Framework for the Sustainable Regulatory Implementation of NAMs DOI
Jonathan Blum, Kristina Bartmann,

Joyce de Paula Souza

et al.

Current Opinion in Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 100528 - 100528

Published: April 1, 2025

Language: Английский

Citations

1
Protecting Human and Animal Health: The Road from Animal Models to New Approach Methods DOI Open Access
Barbara L.F. Kaplan, Alan M. Hoberman, William Slikker

et al.

Pharmacological Reviews, Journal Year: 2024, Volume and Issue: 76(2), P. 251 - 266

Published: Jan. 5, 2024

Animals and animal models have been invaluable for our current understanding of human biology, including physiology, pharmacology, biochemistry, disease pathology. However, there are increasing concerns with continued use animals in basic biomedical, pharmacological, regulatory research to provide safety assessments drugs chemicals. There that do not sufficient information on toxicity and/or efficacy protect the target population, so scientists utilizing principles replacement, reduction, refinement (the 3Rs) development application new approach methods (NAMs). NAMs any technology, methodology, approach, or assay used understand effects mechanisms chemicals, specific focus applying 3Rs. Although progress has made several areas NAMs, complete replacement is yet attainable. The road requires additional development, increased use, and, decision making, usually formal validation. Moreover, it likely will require multiple assays ensure biologic coverage. purpose this manuscript a balanced view state as approaches safety, efficacy, testing all needed nor but each can elucidate key pieces puzzle biology contribute goal protecting health.

Significance Statement

Data from traditional studies predominantly inform health efficacy. unlikely be able replaced, advancement (NAMs), possible sometime future, an important component by which discovery, chemicals conducted decisions made.

Language: Английский

Citations

9
Revolutionizing developmental neurotoxicity testing – a journey from animal models to advanced in vitro systems DOI Creative Commons
Lena Smirnova, Helena T. Högberg, Marcel Leist

et al.

ALTEX, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Developmental neurotoxicity (DNT) testing has seen enormous progress over the last two decades. Preceding even publication of animal-based OECD test guideline for DNT in 2007, a series non-animal technology workshops and conferences (starting 2005) shaped community that delivered comprehensive battery vitro methods (IVB). Its data interpretation is covered by very recent guidance (No. 377). Here, we aim to overview field, focusing on evolution strategies, role emerging technologies, impact guidelines testing. In particular, this an example targeted development animal-free approach one most complex hazards chemicals human health. These developments started literally from blank slate, with no proposed alternative available. Over decades, cutting-edge science enabled design spares animals enables throughput challenging hazard. While it evident field needs regulation, massive economic decreased cognitive capacity caused chemical exposure should be prioritized more highly. Beyond this, claim fame scientific brought understanding brain, its development, how can perturbed. Plain language summaryDevelopmental predicts hazard brain development. Comprehensive advanced strategies using now replace approaches assess large numbers accurately efficiently than approach. Recent formalized DNT, marking pivotal achievement field. The shift towards reflects both commitment animal welfare growing recognition public health impacts associated impaired function exposures. innovations ultimately contribute safer management better protection health, especially during vulnerable stages

Language: Английский

Citations

8
A zebrafish-based acoustic motor response (AMR) assay to evaluate chemical-induced developmental neurotoxicity DOI

Demetrius McAtee,

Ahmed Abdelmoneim

NeuroToxicology, Journal Year: 2024, Volume and Issue: 103, P. 60 - 70

Published: June 6, 2024

Language: Английский

Citations

5
How neurobehavior and brain development in alternative whole-organism models can contribute to prediction of developmental neurotoxicity DOI Creative Commons
Eva‐Maria S. Collins, Ellen V.S. Hessel, Samantha Hughes

et al.

NeuroToxicology, Journal Year: 2024, Volume and Issue: 102, P. 48 - 57

Published: March 28, 2024

Language: Английский

Citations

4
Organoid intelligence for developmental neurotoxicity testing DOI Creative Commons

Dowlette-Mary Alam El Din,

Jeongwon Shin,

Alexandra Lysinger

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Oct. 8, 2024

The increasing prevalence of neurodevelopmental disorders has highlighted the need for improved testing methods to determine developmental neurotoxicity (DNT) hazard thousands chemicals. This paper proposes integration organoid intelligence (OI); leveraging brain organoids study neuroplasticity in vitro, into DNT paradigm. OI brings a new approach measure impacts xenobiotics on plasticity mechanisms – critical biological process that is not adequately covered current vitro assays. Finally, artificial (AI) techniques will further facilitate analysis complex data these mechanisms.

Language: Английский

Citations

4
A peripheral irritant motor response (PIMR) assay to identify chemical-induced locomotor deficits in larval zebrafish (Danio rerio) DOI

Demetrius McAtee,

Ahmed Abdelmoneim

NeuroToxicology, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0
New Approach Methodologies for Developmental Neurotoxicity Testing: Understanding How the Underlying Biology and Assay Characteristics Build Confidence in Using Data to Support Regulatory Decisions DOI
S. Boyd,

Kelly E Carstens,

Anna Lowit

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Identification of neurotoxicology (NT)/developmental neurotoxicology (DNT) adverse outcome pathways and key event linkages with in vitro DNT screening assays DOI
Emily M. Pitzer, Timothy J. Shafer, David W. Herr

et al.

NeuroToxicology, Journal Year: 2023, Volume and Issue: 99, P. 184 - 194

Published: Oct. 20, 2023

Language: Английский

Citations

8
Nanotoxicology: developments and new insights DOI

Henry N. Abonyi,

Ikechukwu Emmanuel Peter, Akachukwu Marytheresa Onwuka

et al.

Nanomedicine, Journal Year: 2024, Volume and Issue: 20(2), P. 225 - 241

Published: Dec. 26, 2024

The use of nanoparticles (NPs) in treatment diseases have increased exponentially recently, giving rise to the science nanomedicine. safety these NPs humans has also led nanotoxicology. Due a dearth both readily available models and precise bio-dispersion characterization techniques, nanotoxicological research obviously been constrained. However, ensuing years were notable for emergence improved synthesis methods tools. Major advances made linking certain physical variables, paralleling improvements size, shape, or coating factors resulting physiological reactions. Although significant progress contribution development nanotoxicology, however, it faces numerous difficulties technical constraints distinct from those conventional toxicological assessment as attempts improve therapeutic effects medicines. Determining thorough standards, standardizing dosimetry, assessing kinetics ions dissolving enhancing accuracy vitro-in vivo correlation efficiency, defining restrictions on exposure protection are some most important pressing concerns. This article will explore past advancement potential prospects standard models, emphasizing findings earlier studies examining current challenges, insight way forward.

Language: Английский

Citations

0