Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Selected practical issues in their evaluation and management

Hepatology, Journal Year: 2008, Volume and Issue: 49(1), P. 306 - 317

Published: Sept. 2, 2008

Nonalcoholic fatty liver disease (NAFLD) is among the most common causes of chronic in western world. It now recognized that these patients have myriad important co-morbidities (e.g., diabetes, hypothyroidism and metabolic syndrome). The workup with suspected NAFLD should consist excluding competing etiologies systemic evaluation comorbidities. histologically categorized into steatosis steatohepatitis, two states fairly dichotomous natural history. While significant progress has been made terms noninvasively predicting advanced fibrosis, insufficient steatohepatitis. Currently, biopsy remains gold standard for histological stratification NAFLD. sustained weight loss can be effective to treat NASH, it often difficult achieve. Foregut bariatric surgery quite improving hepatic histology selected without failure or portal hypertension. Thiazolidinediones shown promise results from ongoing, large multicenter study become available soon. Large studies CB, receptor anatagonists are also underway but their will not several years. Several recent highlighted cardiovascular single cause morbidity mortality this patient population. Conclusion: Health care providers only focus on concentrate aggressively modifying treating risk factors. (HEPATOLOGY 2009;49:306-317.)

Language: Английский

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Increased Hepatic and Circulating Interleukin-6 Levels in Human Nonalcoholic Steatohepatitis

The American Journal of Gastroenterology, Journal Year: 2008, Volume and Issue: 103(6), P. 1372 - 1379

Published: May 28, 2008

Dogru, Teoman M.D.; Ercin, Cemal Nuri Erdem, Gokhan Sonmez, Alper Tapan, Serkan Tasci, Ilker M.D. Author Information

Language: Английский

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Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes

Journal of Gastroenterology and Hepatology, Journal Year: 2009, Volume and Issue: 24(5), P. 830 - 840

Published: Jan. 14, 2009

Abstract Background and Aim: Studies have shown monounsaturated oleic acid to be less toxic than palmitic prevent/attenuate hepatocites toxicity in steatosis models vitro . However, what degree these effects are mediated by extent is unknown. Methods: We evaluated whether per se associated with hepatocytes apoptosis determined the role of acid, most abundant fatty acids western diets, on triglyceride accumulation an model induced three hepatocytic cell lines (HepG2, HuH7, WRL68). The impact incubation for 24 h (0.66 1.32 mM) (0.33 0.66 mM), alone or combined (molar ratio 2 : 1) steatosis, apoptosis, insulin signalling, was evaluated. Results: Concurrent PPARγ SREBP‐1 gene activation, larger when cells were treated acid; latter increased PPARα expression. Cell inversely proportional deposition. Moreover, palmitic, but not impaired signalling. Despite higher amount fat resulting from two combined, rate signalling lower alone, indicating a protective effect acid. Conclusions: Oleic more steatogenic apoptotic hepatocityc cultures. These data may provide biological basis clinical findings dietary patterns pathogenetic nonalcoholic liver disease.

Language: Английский

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Nonalcoholic Fatty Liver Disease: Pathogenesis and Disease Spectrum

Annual Review of Pathology Mechanisms of Disease, Journal Year: 2016, Volume and Issue: 11(1), P. 451 - 496

Published: March 16, 2016

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of dysfunction in Western world and increasing owing to its close association with obesity insulin resistance. NAFLD represents a spectrum that, minority patients, can lead progressive nonalcoholic steatohepatitis (NASH), fibrosis, ultimately hepatocellular carcinoma failure. complex trait resulting from interaction between environmental exposure susceptible polygenic background comprising multiple independent modifiers risk, such as microbiome. The molecular mechanisms that combine define transition NASH are complex, consequently, no pharmacological therapy currently exists treat NASH. A better understanding pathogenesis critical if new treatments be discovered.

Language: Английский

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Cellular and Molecular Mechanisms of Liver Injury

Gastroenterology, Journal Year: 2008, Volume and Issue: 134(6), P. 1641 - 1654

Published: May 1, 2008

Language: Английский

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