Transplant oncology and anti-cancer immunosuppressants

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 7, 2025

Organ transplantation is a life-saving intervention that enhances the quality of life for patients with end-stage organ failure. However, long-term immunosuppressive therapy required to prevent allogeneic graft rejection, which inadvertently elevates risk post-transplant malignancies, especially liver transplant recipients prior history cancer. In response, emerging field oncology integrates principles from and immunology improve outcomes at high tumor occurrence or recurrence following transplantation. Therefore, it substantial clinical significance develop immunosuppressants possess both anti-tumor properties. For instance, mTOR inhibitors demonstrate effects among antimetabolite drugs, recent studies indicate capecitabine, an chemotherapeutic, may also exhibit activity in clinic transplants suffering hepatocellular carcinoma. This review systematically explores potential dual support management elevated recurrence.

Language: Английский

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Looking Back, Moving Forward: Challenges and Opportunities for Global Cervical Cancer Prevention and Control

Viruses, Journal Year: 2024, Volume and Issue: 16(9), P. 1357 - 1357

Published: Aug. 25, 2024

Despite the introduction of Pap testing for screening to prevent cervical cancer in mid-20th century, remains a common cause cancer-related mortality and morbidity globally. This is primarily due differences access care between low-income high-income resource settings, resulting being one cancers with greatest health disparity. The discovery human papillomavirus (HPV) as near-obligate viral can revolutionize how it be prevented: HPV vaccination against infection prophylaxis testing-based detection treatment pre-cancers interception. As result this progress, World Health Organization has championed elimination global problem. However, unless research, investments, actions are taken ensure equitable these highly effective preventive interventions, there real threat exacerbating current inequities cancer. In review, progress date challenges opportunities fulfilling potential HPV-targeted prevention control discussed.

Language: Английский

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Prevention and control of HPV-related cancers in people living with HIV

The Lancet HIV, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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De novo colorectal cancer after kidney transplantation: a systematic review and meta-analysis

British Journal of Cancer, Journal Year: 2025, Volume and Issue: unknown

Published: April 5, 2025

Language: Английский

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Characteristics of HPV Infection in Women Cervical and Anal with HIV-Infected and the Advances in Epidemiological Research

Infection and Drug Resistance, Journal Year: 2025, Volume and Issue: Volume 18, P. 1785 - 1791

Published: April 1, 2025

Antiretroviral therapy (ART) has significantly reduced the incidence and mortality of AIDS-related diseases, bringing life expectancy human immunodeficiency virus (HIV)-infected individuals close to that uninfected individuals. However, rates tumors associated with papillomavirus (HPV) have not decreased. Persistent infection high-risk HPV is a major cause cervical cancer other related malignancies, risk diseases are higher among HIV-infected Although World Health Organization provides screening recommendations for general population, there lack guidelines anal specifically in HIV-positive patients. Further research urgently needed develop effective preventive measures. This article reviews epidemiological characteristics associations infections cancers women, providing reference prevention treatment.

Language: Английский

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Expanding the list of cancers recognized to be caused by infectious agents

JNCI Journal of the National Cancer Institute, Journal Year: 2024, Volume and Issue: 116(12), P. 1875 - 1877

Published: Aug. 22, 2024

Language: Английский

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